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1 Neurosurgical Trials Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
2 Health Economics Research Unit, University of Aberdeen, Aberdeen, UK
3 Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK
4 South Tees Hospitals Foundation Trust, James Cook University Hospital, Middlesbrough, UK
5 Department of Neurosurgery, University of Heidelberg, D-69120 Heidelberg, Germany
* Corresponding author Email: barbara.gregson@ncl.ac.uk
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