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Heather Lambert, Shaun Hiu, Malcolm Coulthard, John N S Matthews, Ruth Wood, Jean Crosier, Rachel Agbeko, Thomas Brick, Heather Duncan, David Grant, Quen Mok, Andrew Gustaf Nyman, John Pappachan, Paul Wellman, Chris Boucher, Joe Bulmer, Denise Chisholm, Kirsten Cromie, Victoria Emmet, Richard Feltbower, Michael Grayling, Rebecca Harrison, Eva-Maria Holstein, Ciara A Kennedy, Elaine McColl, Kevin Morris, Lee Norman, Julie Office, Roger Parslow, Christine Pattinson, Shriya Sharma, Jonathan Smith, Alison Steel, Rachel Steel, Jayne Straker, Lamprini Vrana, Jenn Walker, Mike Whitaker, Jim Wightman, Nina Wilson & Lucy Wirz.

Heather Lambert ^1,*, Shaun Hiu ², Malcolm Coulthard ¹, John N S Matthews ^2,3, Ruth Wood ⁴, Jean Crosier ¹, Rachel Agbeko ¹, Thomas Brick ⁵, Heather Duncan ⁶, David Grant ⁷, Quen Mok ⁸, Andrew Gustaf Nyman ⁹, John Pappachan ¹⁰, Paul Wellman ⁹, Chris Boucher ¹¹, Joe Bulmer ¹², Denise Chisholm ¹³, Kirsten Cromie ¹⁴, Victoria Emmet ¹³, Richard Feltbower ¹⁴, Michael Grayling ², Rebecca Harrison ¹², Eva-Maria Holstein ⁴, Ciara A Kennedy ⁴, Elaine McColl ², Kevin Morris ⁶, Lee Norman ¹⁴, Julie Office ¹³, Roger Parslow ¹⁵, Christine Pattinson ¹³, Shriya Sharma ⁴, Jonathan Smith ¹⁶, Alison Steel ⁴, Rachel Steel ¹³, Jayne Straker ¹³, Lamprini Vrana ¹⁶, Jenn Walker ⁴, Mike Whitaker ¹², Jim Wightman ¹², Nina Wilson ², Lucy Wirz ¹³

¹ Paediatric Nephrology, Great North Children’s Hospital, Royal Victoria Infirmary, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK
² Biostatistics Research Group, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK
³ School of Mathematics, Statistics & Physics, University of Newcastle, Newcastle Upon Tyne, UK
⁴ Newcastle Clinical Trials Unit, Newcastle University, Newcastle Upon Tyne, UK
⁵ Cardiac Intensive Care Unit, Great Ormond Street Hospital NHS Trust, London, UK
⁶ Department of Paediatric Intensive Care, Birmingham Women’s and Children’s Hospital, Birmingham, UK
⁷ Bristol Royal Hospital for Children and University of Bristol Medical School, Bristol, UK
⁸ PICU, Great Ormond Street Children’s hospital, London, UK
⁹ Paediatric Intensive Care Unit, Evelina London Children’s Hospital, London, UK
¹⁰ Southampton Children’s Hospital, Southampton NIHR Biomedical Centre, Southampton, UK
¹¹ , ,
¹² Northern Medical Physics and Clinical Engineering, Royal Victoria Infirmary, Newcastle Upon Tyne, UK
¹³ Clinical Resource Building, Royal Victoria Infirmary, Newcastle Upon Tyne, UK
¹⁴ Leeds Institute for Data Analytics, School of Medicine, Leeds, UK
¹⁵ Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, Leeds, UK
¹⁶ PICU, Freeman Hospital, Newcastle Upon Tyne NHS Foundation Trust, Newcastle Upon Tyne, UK
^* Corresponding author Email: Heather.Lambert@nhs.net

Disclosure of interests

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/VGJT3714.

Primary conflicts of interest: Malcolm Coulthard – possibility that eventually the successful marketing of the NIDUS® (Allmed, www.allmedgroup.com) device could lead MC receiving a proportion of the royalties received from the manufacturer (Allmed) by the Newcastle upon Tyne Hospitals NHS Foundation Trust. David Grant – A member of the Global Network for Simulation in Healthcare Board. Rachel Agbeko – Editor for The British Medical Journal and supported by NIHR grants via substantive employer (NHS). Elaine McColl – NIHR CTU Standing Advisory Committee board membership from January 2015 to June 2016.