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Adding levosimendan to standard care for patients with septic shock did not reduce organ dysfunction, and may have increased risk of serious adverse events.
1 Section of Anaesthetics, Pain Medicine and Intensive Care Medicine, Department of Surgery and Cancer, Imperial College London and Imperial College Healthcare NHS Trust, London, UK
2 Imperial Clinical Trials Unit, Imperial College London, London, UK
3 Department of Critical Care, Cheltenham General Hospital, Cheltenham, UK
4 Warwick Clinical Trials Unit, University of Warwick and Heart of England NHS Foundation Trust, Coventry, UK
5 Bloomsbury Institute for Intensive Care Medicine, Division of Medicine, University College London, London, UK
6 Centre for Experimental Medicine, Queen’s University Belfast, Belfast, UK
7 Regional Intensive Care Unit, The Royal Hospitals, Belfast, UK
8 Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK
9 Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK
* Corresponding author Email: anthony.gordon@imperial.ac.uk
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