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Minocycline did not delay the progress of cognitive or functional impairment in people with mild Alzheimer's disease over 2 years and minocycline 400 mg was poorly tolerated.

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Robert Howard 1,*, Olga Zubko 2, Richard Gray 3, Rosie Bradley 4, Emma Harper 4, Linda Kelly 4, Lynn Pank 4, John O’Brien 5, Chris Fox 6, Naji Tabet 7, Gill Livingston 1, Peter Bentham 8, Rupert McShane 9, Alistair Burns 10, Craig Ritchie 11, Suzanne Reeves 1, Simon Lovestone 9, Clive Ballard 12, Wendy Noble 13, Gordon Wilcock 14, Ramin Nilforooshan 15

1 Division of Psychiatry, University College London, London, UK
2 Department of Old Age Psychiatry, King’s College London, London, UK
3 Nuffield Department of Population Health, University of Oxford, Oxford, UK
4 Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK
5 Department of Psychiatry, University of Cambridge, Cambridge, UK
6 Norwich Medical School, University of East Anglia, Norwich, UK
7 Department of Old Age Psychiatry, University of Sussex, Brighton, UK
8 The Barberry Centre, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK
9 Department of Psychiatry, University of Oxford, Oxford, UK
10 Department of Old Age Psychiatry, University of Manchester, Manchester, UK
11 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
12 Medical School, University of Exeter, Exeter, UK
13 Department of Basic and Clinical Neuroscience, King’s College London, London, UK
14 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
15 Abraham Cowley Unit, Surrey and Borders Partnership NHS Foundation Trust, Redhill, UK
* Corresponding author Email: robert.howard@ucl.ac.uk

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