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This study demonstrated that the performance of first-trimester screening for pre-eclampsia by a combination of maternal factors and biomarkers was superior to that achieved by current NICE guidelines.

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Liona C Poon 1, David Wright 2, Steve Thornton 3, Ranjit Akolekar 4, Peter Brocklehurst 5, Kypros H Nicolaides 1,*

1 Fetal Medicine Research Institute, King’s College Hospital, King’s College London, London, UK
2 Institute of Health Services Research, University of Exeter, Exeter, UK
3 Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK
4 Department of Obstetrics and Gynaecology, Medway Maritime Hospital, Kent, UK
5 Comprehensive Clinical Trials Unit, University College London, London, UK
* Corresponding author Email: kypros@fetalmedicine.com

Declared competing interests of authors: Steve Thornton reports grants from the National Institute for Health Research (NIHR), the British Heart Foundation (BHF) and Barts Charity during the conduct of the study. Outside the submitted work, he was a member of the NIHR Efficacy and Mechanism Evaluation Editorial Board (2016–19), a trustee of Wellbeing of Women until 2019 (London, UK), MedCity (London, UK) and the William Harvey Research Institute (London, UK). He provides consultancy advice for commercial organisations [i.e. GlaxoSmithKline plc (Brentford, UK), Hologic, Inc. (Bedford, MA, USA), and Ferring Pharmaceuticals (Saint-Prex, Switzerland)]. He is a non-executive director of the NHS Trust (2016 to present). Ranjit Akolekar and Kypros H Nicolaides are trustees of the Fetal Medicine Foundation. Peter Brocklehurst reports grants and personal fees from the Medical Research Council (London, UK), grants from the NIHR Services and Delivery Research programme, the NIHR Health Technology Assessment (HTA) programme and the Wellcome Trust (London, UK) outside the submitted work. He was chairperson of the NIHR HTA Maternal, Neonatal and Child Health Panel and the Medical Research Council Methodology Research Programme Panel between 2014 and 2018.

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