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This trial showed ursodeoxycholic acid does not reduce adverse perinatal outcomes in intrahepatic cholestasis of pregnancy.

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Lucy C Chappell 1,*, Jennifer L Bell 2, Anne Smith 2, Catherine Rounding 2, Ursula Bowler 2, Louise Linsell 2, Edmund Juszczak 2, Sue Tohill 1, Amanda Redford 3, Peter H Dixon 1, Jenny Chambers 4, Rachael Hunter 5, Jon Dorling 6, Catherine Williamson 1,, Jim G Thornton 3,

1 Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, London, UK
2 National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
3 Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK
4 ICP Support, Sutton Coldfield, UK
5 Research Department of Primary Care and Population Health, University College London, London, UK
6 Division of Neonatal-Perinatal Medicine, IWK Health Centre, Halifax, NS, Canada
* Corresponding author Email: lucy.chappell@kcl.ac.uk

Joint senior authors

Joint senior authors

Declared competing interests of authors: Lucy C Chappell reports that she is chairperson of the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Clinical Evaluation and Trials Committee (January 2019 to present), a member of the NIHR Efficacy and Mechanism Evaluation (EME) Strategic Advisory Committee (from November 2019 to present) and is funded by a NIHR Professorship (award number RP-2014-5-019). Jon Dorling reports that he was funded by Nutrinia Ltd. (Ramat Gan, Israel) in 2017 and 2018 for part of his salary to work as an expert advisor on a trial of enteral insulin. Jim G Thornton reports that he is a co-author of the Cochrane review of treatment for obstetric cholestasis, a co-author of a previous trial of ursodeoxycholic acid to treat intrahepatic cholestasis of pregnancy and that he is a member of the NIHR HTA and EME Editorial Board.

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