Systematic review of the clinical effectiveness and cost-effectiveness of photodynamic diagnosis and urine biomarkers (FISH, ImmunoCyt, NMP22) and cytology for the detection and follow-up of bladder cancer

Mowatt, G; Zhu, S; Kilonzo, M; Boachie, C; Fraser, C; Griffiths, TRL; N’Dow, J; Nabi, G; Cook, J; Vale, L

doi:10.3310/hta14040

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Review found that photodynamic diagnosis and urine biomarkers have higher sensitivity but lower specificity than white light cystoscopy and cytology, respectively, in detecting bladder cancer and that diagnostic strategies involving biomarkers and/or photodynamic diagnosis provide additional benefits at a cost that society might be willing to pay

G Mowatt, S Zhu, M Kilonzo, C Boachie, C Fraser, TRL Griffiths, J N’Dow, G Nabi, J Cook & L Vale.

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G Mowatt ^1,^*, S Zhu ¹, M Kilonzo ², C Boachie ¹, C Fraser ¹, TRL Griffiths ³, J N’Dow ⁴, G Nabi ⁴, J Cook ¹, L Vale ^1,²

¹ Health Services Research Unit, Institute of Applied Health Sciences, University of Aberdeen, , UK
² Health Economics Research Unit, Institute of Applied Health Sciences, University of Aberdeen, , UK
³ Department of Cancer Studies and Molecular Medicine, University of Leicester, , UK
⁴ Academic Urology Unit, Department of Surgery, University of Aberdeen, , UK
^* Corresponding author Email: g.mowatt@abdn.ac.uk

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