BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A

Shaw, L; Rodgers, H; Price, C; van Wijck, F; Shackley, P; Steen, N; Barnes, M; Ford, G; Graham, L

doi:10.3310/hta14260

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The addition of botulinum toxin type A to an upper limb therapy programme for post stroke spasticity did not improve active upper limb function, but was useful for improving basic functional tasks (e.g. hand hygiene) and pain. However, treatment was not cost-effective at willingness-to-pay levels of NHS decision makers.

L Shaw, H Rodgers, C Price, F van Wijck, P Shackley, N Steen, M Barnes, G Ford & L Graham.

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L Shaw ¹, H Rodgers ^1,^2,^*, C Price ², F van Wijck ³, P Shackley ⁴, N Steen ⁴, M Barnes ⁵, G Ford ¹, L Graham ⁵

¹ Institute for Ageing and Health (Stroke Research Group), Newcastle University, Newcastle upon Tyne, UK
² Northumbria Healthcare NHS Foundation Trust (North Tyneside General Hospital and Wansbeck General Hospital), North Shields and Ashington, UK
³ School of Health Sciences, Queen Margaret University, Edinburgh, UK
⁴ Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
⁵ International Centre for Neurorehabilitation, Newcastle upon Tyne, UK
^* Corresponding author Email: helen.rodgers@ncl.ac.uk

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