Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model

Pufulete, Maria; Maishman, Rachel; Dabner, Lucy; Mohiuddin, Syed; Hollingworth, William; Rogers, Chris A; Higgins, Julian; Dayer, Mark; Macleod, John; Purdy, Sarah; McDonagh, Theresa; Nightingale, Angus; Williams, Rachael; Reeves, Barnaby C

doi:10.3310/hta21400

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The efficacy of BNP-guided-therapy in specialist heart failure clinics is uncertain, but if efficacious, it would be cost-effective for patients under 75 with reduced ejection fraction.

Maria Pufulete, Rachel Maishman, Lucy Dabner, Syed Mohiuddin, William Hollingworth, Chris A Rogers, Julian Higgins, Mark Dayer, John Macleod, Sarah Purdy, Theresa McDonagh, Angus Nightingale, Rachael Williams & Barnaby C Reeves.

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Maria Pufulete ¹, Rachel Maishman ¹, Lucy Dabner ¹, Syed Mohiuddin ², William Hollingworth ², Chris A Rogers ¹, Julian Higgins ², Mark Dayer ³, John Macleod ², Sarah Purdy ², Theresa McDonagh ⁴, Angus Nightingale ⁵, Rachael Williams ⁶, Barnaby C Reeves ^1,^*

¹ Clinical Trials and Evaluation Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
² School of Social and Community Medicine, University of Bristol, Bristol, UK
³ Department of Cardiology, Taunton and Somerset NHS Foundation Trust, Taunton, UK
⁴ Cardiovascular Division, King’s College London, King’s College Hospital, London, UK
⁵ Department of Cardiology, Bristol Heart Institute, Bristol Royal Infirmary, Bristol, UK
⁶ Clinical Practice Research Datalink, Medicines and Healthcare products Regulatory Agency, London, UK
^* Corresponding author Email: barney.reeves@bristol.ac.uk

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