Alternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT

Brown, Sarah; Everett, Colin C; Naraghi, Kamran; Davies, Claire; Dawkins, Bryony; Hulme, Claire; McCabe, Christopher; Pavitt, Sue; Emery, Paul; Sharples, Linda; Buch, Maya H

doi:10.3310/hta22340

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This 3-arm trial in rheumatoid arthritis stopped early because of contractual issues and commissioning challenges, but 122 randomised participants were followed up, generating evidence for future meta-analyses.

Sarah Brown, Colin C Everett, Kamran Naraghi, Claire Davies, Bryony Dawkins, Claire Hulme, Christopher McCabe, Sue Pavitt, Paul Emery, Linda Sharples & Maya H Buch.

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Sarah Brown ¹, Colin C Everett ¹, Kamran Naraghi ², Claire Davies ¹, Bryony Dawkins ³, Claire Hulme ³, Christopher McCabe ⁴, Sue Pavitt ⁵, Paul Emery ^3,⁶, Linda Sharples ¹, Maya H Buch ^3,^6,^*

¹ Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK
² Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK
³ Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
⁴ Department of Emergency Medicine, University of Alberta, Edmonton, AB, Canada
⁵ Dental Translational and Clinical Research Unit, University of Leeds, Leeds, UK
⁶ National Institute for Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK
^* Corresponding author Email: m.buch@leeds.ac.uk

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