Anaesthetic analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT

Hay, Alastair D; Downing, Harriet; Francis, Nick A; Young, Grace J; Clement, Clare; Harris, Sue D; Ahern, Aideen; Schofield, Behnaz; Thomas, Tammy E; Horwood, Jeremy; Blair, Peter S; Hollingworth, William; Wilson, Victoria; Metcalfe, Chris; Stoddart, Peter; Nunez, Desmond; Lyttle, Mark D; Little, Paul; Moore, Michael V

doi:10.3310/hta23340

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Anaesthetic analgesic eardrops reduced antibiotic consumption, but a short recruitment period led to a reduced sample size and imprecise treatment effect estimates.

Alastair D Hay , Harriet Downing , Nick A Francis , Grace J Young , Clare Clement , Sue D Harris , Aideen Ahern , Behnaz Schofield , Tammy E Thomas , Jeremy Horwood , Peter S Blair , William Hollingworth , Victoria Wilson , Chris Metcalfe , Peter Stoddart , Desmond Nunez , Mark D Lyttle , Paul Little & Michael V Moore .

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Alastair D Hay ^1,^*, Harriet Downing ², Nick A Francis ³, Grace J Young ⁴, Clare Clement ⁴, Sue D Harris ¹, Aideen Ahern ⁴, Behnaz Schofield ³, Tammy E Thomas ⁵, Jeremy Horwood ^1,⁴, Peter S Blair ⁴, William Hollingworth ⁶, Victoria Wilson ¹, Chris Metcalfe ⁴, Peter Stoddart ⁷, Desmond Nunez ⁸, Mark D Lyttle ⁷, Paul Little ⁵, Michael V Moore ⁵

¹ Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
² National Institute for Health Research Biomedical Research Centre, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
³ Division of Population Medicine, Cardiff University, Cardiff, UK
⁴ Bristol Randomised Trials Collaboration, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
⁵ Primary Care and Population Sciences, University of Southampton, Southampton, UK
⁶ Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
⁷ Bristol Royal Hospital for Children, Bristol, UK
⁸ Division of Otolaryngology, Department of Surgery, University of British Columbia, Vancouver, BC, Canada
^* Corresponding author Email: alastair.hay@bristol.ac.uk

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