Prehospital continuous positive airway pressure for acute respiratory failure: the ACUTE feasibility RCT

Fuller, Gordon W; Keating, Samuel; Goodacre, Steve; Herbert, Esther; Perkins, Gavin D; Rosser, Andy; Gunson, Imogen; Miller, Joshua; Ward, Matthew; Bradburn, Mike; Thokala, Praveen; Harris, Tim; Marsh, Margaret M; Scott, Alexander J; Cooper, Cindy

doi:10.3310/hta25070

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This study concluded that prehospital use of CPAP for Acute Respiratory Failure was not feasible for a full trial largely because it seems unlikely to materially reduce mortality.

Gordon W Fuller , Samuel Keating , Steve Goodacre , Esther Herbert , Gavin D Perkins , Andy Rosser , Imogen Gunson , Joshua Miller , Matthew Ward , Mike Bradburn , Praveen Thokala , Tim Harris , Margaret M Marsh , Alexander J Scott & Cindy Cooper .

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Gordon W Fuller ^1,^*, Samuel Keating ², Steve Goodacre ¹, Esther Herbert ², Gavin D Perkins ³, Andy Rosser ⁴, Imogen Gunson ⁴, Joshua Miller ⁴, Matthew Ward ⁴, Mike Bradburn ², Praveen Thokala ⁵, Tim Harris ⁶, Margaret M Marsh ⁷, Alexander J Scott ², Cindy Cooper ²

¹ Centre for Urgent and Emergency Care Research, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
² Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
³ Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
⁴ West Midlands Ambulance Service, Brierley Hill, UK
⁵ Health Economics and Decision Science, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK
⁶ Centre for Neuroscience and Trauma, Blizard Institute, Queen Mary University of London, London, UK
⁷ Sheffield Emergency Care Forum, Royal Hallamshire Hospital, Sheffield, UK
^* Corresponding author Email: g.fuller@sheffield.ac.uk

Declared competing interests of authors: Steve Goodacre is Deputy Director of the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (2016–present), chairperson of the NIHR HTA Commissioning Board (2016–present) and a member of the NIHR HTA Funding Strategy Group (2016–present). Esther Herbert reports grants from NIHR during the conduct of the study, outside the submitted work. Gavin Perkins is a NIHR Senior Investigator and a member of the Programme Grants for Applied Research board (2016–present). Cindy Cooper is a member of the NIHR Clinical Trials Unit Standing Advisory Committee (2016–present) and of the UK Clinical Research Collaboration Registered Clinical Trials Unit Network Executive Group (2016–present).

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