Pharmacological and non-pharmacological treatments and outcomes for new-onset atrial fibrillation in ICU patients: the CAFE scoping review and database analyses

Bedford, Jonathan; Drikite, Laura; Corbett, Mark; Doidge, James; Ferrando-Vivas, Paloma; Johnson, Alistair; Rajappan, Kim; Mouncey, Paul; Harrison, David; Young, Duncan; Rowan, Kathryn; Watkinson, Peter

doi:10.3310/hta25710

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New-onset atrial fibrillation in ICU patients is associated with poor outcomes, and although evidence for its management is limited, beta-blockers and amiodarone appear similarly effective, and superior to digoxin and calcium channel blockers.

Jonathan Bedford , Laura Drikite , Mark Corbett , James Doidge , Paloma Ferrando-Vivas , Alistair Johnson , Kim Rajappan , Paul Mouncey , David Harrison , Duncan Young , Kathryn Rowan & Peter Watkinson .

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Jonathan Bedford ^1,^*, Laura Drikite ², Mark Corbett ³, James Doidge ², Paloma Ferrando-Vivas ², Alistair Johnson ⁴, Kim Rajappan ⁵, Paul Mouncey ², David Harrison ², Duncan Young ¹, Kathryn Rowan ², Peter Watkinson ^1,⁶

¹ Kadoorie Centre for Critical Care Research and Education, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
² Intensive Care National Audit and Research Centre, London, UK
³ Centre for Reviews and Dissemination, University of York, York, UK
⁴ Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA, USA
⁵ Department of Cardiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
⁶ Adult Intensive Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
^* Corresponding author Email: Jonathan.bedford@ndcn.ox.ac.uk

Declared competing interests of authors: Peter Watkinson worked part time for Sensyne Health (Oxford, UK); has received grant funding from the National Institute for Health Research (NIHR) and Sensyne Health outside the submitted work; was a member of the Health Technology Assessment (HTA) Elective and Emergency Specialist Care (EESC) Methods Group (2014–17), HTA EESC Panel (2013–18), HTA Prioritisation Committee B (in hospital) (2018–19) and NIHR Invention for Innovation (i4i) Programme for Product Development Awards Committee (2018 to present); and is supported by the NIHR Biomedical Research Centre, Oxford. Kathryn Rowan was a member of the Department of Health and Social Care/UK Research and Innovation COVID-19 Rapid Response Research Initiative and the College of Experts 2020, and was a Health Services and Delivery Research (HSDR) Programme Funding Committee Member (2014–19), HSDR Rapid Service Evaluation Themed Call Committee Member (2017), HSDR Commissioned Board Member (2016) and HTA Trauma Themed Call Board Member (2007–8). Duncan Young received a salary from the University of Oxford (Oxford, UK) during the duration of the work. Jonathan Bedford is funded by an award to the University of Oxford, NIHR Doctoral Research Fellowship 300224.

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