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This trial found an early structured exercise programme improved upper limb function at 1 year in those at risk of shoulder problems after breast cancer surgery.

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Julie Bruce 1,*, Bruno Mazuquin 1, Pankaj Mistry 1, Sophie Rees 1, Alastair Canaway 1, Anower Hossain 1,2, Esther Williamson 3,4, Emma J Padfield 1, Ranjit Lall 1, Helen Richmond 5, Loraine Chowdhury 1, Clare Lait 6, Stavros Petrou 1,7, Katie Booth 1, Sarah E Lamb 4, Raghavan Vidya 8, Alastair M Thompson 9

1 Warwick Clinical Trials Unit, Division of Health Sciences, University of Warwick, Coventry, UK
2 Institute of Statistical Research and Training (ISRT), University of Dhaka, Dhaka, Bangladesh
3 Centre for Rehabilitation Research, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
4 College of Medicine and Health, University of Exeter, Exeter, UK
5 Primary Healthcare Research Unit, Faculty of Medicine, Memorial University of Newfoundland, St John’s, NL, Canada
6 Gloucestershire Care Services NHS Trust, Gloucester, UK
7 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
8 Royal Wolverhampton NHS Trust, Wolverhampton, UK
9 Baylor College of Medicine, Houston, TX, USA
* Corresponding author Email: julie.bruce@warwick.ac.uk

Declared competing interests of authors: Julie Bruce is co-investigator on current research grants from the National Institute for Health Research (NIHR) (NIHR202618, HTA 17/129/02, NIHR128311, NIHR132046, HTA 131407 and HTA 10/42/02), British Heart Foundation (PG/19/22/34203) and Diabetes UK (17/0005690), and is supported by the NIHR Research Capability Funding via University Hospitals Coventry and Warwickshire NHS Trust. Clare Lait provides private physiotherapy to cancer patients outside the submitted work. Sarah E Lamb reports grants from the NIHR Health Technology Assessment (HTA) programme during the conduct of the study and was a member of the following boards: HTA Additional Capacity Funding Board (2012–15); HTA Clinical Trials Board (2010–15), HTA End of Life Care and Add on Studies (2015), HTA Funding Boards Policy Group (formerly Clinical Studies Group) (2010–15), HTA Post-board funding teleconference (policy group members to attend) (2010–15), HTA Maternal, Neonatal and Child Health Methods Group (2013–15), HTA Primary Care Themed Call Board (2013–14), HTA Prioritisation Group (2010–15) and NIHR Clinical Trials Unit Standing Advisory Committee (2012–16).

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