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This research programme found that homeless people and prisoners have high levels of undiagnosed latent TB and hepatitis C, and smartphone-enabled video was more effective and cheaper than direct observation of TB.

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Alistair Story 1,2, Elizabeth Garber 1,3, Robert W Aldridge 1, Catherine M Smith 1, Joe Hall 1,3, Gloria Ferenando 1,3, Lucia Possas 1,3, Sara Hemming 1,3, Fatima Wurie 1, Serena Luchenski 1, Ibrahim Abubakar 4, Timothy D McHugh 5, Peter J White 6,7,8, John M Watson 9, Marc Lipman 3,10, Richard Garfein 11, Andrew C Hayward 12,*

1 Institute of Health Informatics, University College London, London, UK
2 Find&Treat, University College Hospitals NHS Foundation Trust, London, UK
3 Royal Free London NHS Foundation Trust, London, UK
4 Institute for Global Health, University College London, London, UK
5 Centre for Clinical Microbiology, University College London, London, UK
6 Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK
7 National Institute for Health Research Health Protection Research Unit in Modelling Methodology, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK
8 Modelling and Economics Unit, National Infection Service, Public Health England, London, UK
9 Research Department of Infection and Population Health, University College London, London, UK
10 Respiratory Medicine, Division of Medicine, University College London, London, UK
11 Division of Global Public Health, School of Medicine, University of California, San Diego, CA, USA
12 Institute of Epidemiology and Health Care, University College London, London, UK
* Corresponding author Email: a.hayward@ucl.ac.uk

Declared competing interests of authors: Alistair Story leads the Find&Treat service that manages the video-observed treatment. Peter White reports grants from the Medical Research Council and NIHR during the conduct of the study and grants from Otsuka Pharmaceutical Co., Ltd (Tokyo, Japan) outside the submitted work. Richard Garfein established SureAdhere Mobile Technology, Inc. (San Diego, CA, USA), which provides a smartphone application for video-observed treatment. Ibrahim Abubakar is a member of the Health Technology Assessment Commissioning Board (2017 to present).

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