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{"sheet":"User instructions","index":0,"n_rows":23,"n_cols":1,"rows_kept":23,"cut":false,"hidden":false,"merged":[]}
["User instructions"]
["Please read this first"]
["Disclaimer"]
["The research team is not responsible if incorrect decisions are made because of the use of this file. This file is provided without any technical support. It is the responsibility of the user to verify that the formulae used in this file are suitable for their needs."]
["Instructions to use the file"]
["1. This file calculates the cost-effectiveness of hyperthermic intraoperative peritoneal chemotherapy (HIPEC) and cytoreductive surgery (CRS) for people with peritoneal metastases described in UK National Institute for Health and Care Research Project HTA 17/135/02."]
["2. It is expected that people with expertise in health economics use this file to tailor the input to the local data."]
["3. This file allows the calculation of cost-effectiveness for the following comparisons."]
["a. Colorectal peritoneal metastases: CRS + HIPEC + systemic chemotherapy vs CRS + systemic chemotherapy"]
["b. Colorectal peritoneal metastases: CRS + HIPEC + systemic chemotherapy vs systemic chemotherapy"]
["c. Gastric peritoneal metastases: CRS + HIPEC + systemic chemotherapy vs CRS + systemic chemotherapy"]
["d. Gastric peritoneal metastases: CRS + HIPEC + systemic chemotherapy vs systemic chemotherapy"]
["e. Ovarian cancer (Stage III or above requiring interval cytoreductive surgery): CRS + HIPEC + systemic chemotherapy vs CRS + systemic chemotherapy"]
["4. We strongly recommend that you save a copy of the original download before you make any alterations, as the file contains formulae which are linked to other sheets. The formulae are not protected to allow you to customise the file to your needs."]
["5. To choose the birth sex and the comparison, please see sheet 'UserInput'."]
["6. For changing the probabilities, costs, and utilities, please see sheet 'SourceData'. The SourceData are linked to cells in other sheets."]
["a. The naming convention used for the calculations of costs, cancer type (CRC, Gastric, and Ovarian for colorectal, stomach, and ovarian cancers respectively) followed by the intervention '_HIPEC_' and control 'CRS' for cytoreductive surgery and 'Chem' for systemic chemotherapy alone.   "]
["b. Calculation of quality adjusted life years is done in the sheet 'QALYCalculation'."]
["c. The estimated life span is based on the UK National life tables and is done in the sheet 'NationalLifeTables'."]
["7. For changing the discount rate and number of iterations, please see sheet 'Input'. "]
["8. When you are ready to perform the analysis, click on 'Analyse' in the sheet 'Input'."]
["9. The results are available from the sheets 'Results', 'Scatterplot', 'CEAC', 'ThresholdSummary' and 'Tornado'. In the scatterplot, one has to manually adjust the cell range to get the correct scatterplot. For example, for 10,000 simulations, the cell range are PSA!$DD$5:$DD$10004,PSA!$DC$5:$DC$10004. For 15,000 simulations, the cell range are PSA!$DD$5:$DD$15004,PSA!$DC$5:$DC$15004 and so on."]
["10. If you want to check the stability, you can do so by clicking on 'Assess stability of model' in the sheet 'Input'. The results are available in the 'Results' sheet."]

{"sheet":"CRC_HIPEC_CRS","index":1,"n_rows":43,"n_cols":11,"rows_kept":43,"cut":false,"hidden":false,"merged":[]}
["Colorectal cancer","HIPEC+CRS+systemic chemotherapy vs CRS+systemic chemotherapy"]
[null,"Unit cost ","Notes/description","Quantity per patient","Exchange rate to GBP","Total mg/m2","Surface area (m2)","Body weight (kg)","Total drug (mg per patient)","Total cost (GBP 2022)","Source"]
["HIPEC costs"]
["HIPEC machine"]
["HIPEC machine (Performer HT)",45000,"Original cost: € 45,000 + VAT. Lifelime of the machine is 10 years. Annuity factor at 5% rate. ",1,1.19,null,null,null,null,{"$f":"IF(D5=\"\",\"\",B5*D5*IF(E5=\"\",1,E5))","v":53550},"Hospital costs; Euro to GBP Exchange rate (ONS 2022)"]
["HIPEC machine service costs per year",5500,"Original cost: € 5,500. Service cost per year. This is the same regardless of volume",1,1.19,null,null,null,null,6545,"Hospital costs"]
["Life time for machine (years)",10,"Local estimate",null,null,null,null,null,null,"","Local estimate"]
["Interest rate",0.05,null,null,null,null,null,null,null,""]
["Annuity factor",{"$f":"(1-(1/(1+B8))^B7)/B8","v":7.7217349291848176},"This is calculated using the formula 1-(1/(1+interest rate))^years/interest rate",null,null,null,null,null,null,"","Drummond et al 2015 Methods for the Economic Evaluation of Health Care Programmes Edition 4"]
["Cost of HIPEC machine per year",{"$f":"(J5/B9)+J6","v":13479.969989400201},"This is calculated as: Cost of HIPEC machine/Annuity factor +HIPEC machine service costs per year (in pounds)",{"$f":"IF(OR(UserInput!$B$8=\"\",UserInput!$B$8<=70),1,ROUNDUP(QUOTIENT(UserInput!$B$8,70),0)+1)","v":1},1,null,null,null,null,13479.969989400201]
["Cost of HIPEC machine per patient",{"$f":"J10/IF(UserInput!$B$8=\"\",70,UserInput!$B$8)","v":192.5709998485743},"The machine volume per year can differ according to the number of procedures. On average, 1 machine is required for every 70 patients per year. The costs per patient are calculated as total machine costs per year/number of patients per year",1,1,null,null,null,null,192.5709998485743]
["HIPEC disposables",null,null,null,null,null,null,null,null,""]
["Hang and Go Set per case",1020,"cost per patient of consumables",1,1,null,null,null,null,1020,"Hospital costs"]
["Cytotoxic disposal per case",1.85,"cost per patient of disposable material",1,1,null,null,null,null,1.85,"Hospital costs"]
["Baxter cost Oxaliplatin",47.5,null,1,1,null,null,null,null,47.5,"Hospital costs"]
["Baxter cost 5FU",26,null,1,1,null,null,null,null,26,"Hospital costs"]
[]
["Total cost of disposables",{"$f":"SUM(J13:J17)","v":1095.3499999999999},null,1,1,null,null,null,null,{"$f":"IF(D18=\"\",\"\",B18*D18*IF(E18=\"\",1,E18))","v":1095.3499999999999}]
["HIPEC pratitioner",null,null,null,null,null,null,null,null,""]
["HIPEC pratitioner salary (p.a)",65,"This is a pratictioner that runs and maintains the machine. The salary range here is £40,057-£45,839. Average 5.5hs per case. Assuming 47.5 hours per week, 42 weeks a year, the cost per hour is £65. Time per case is 5.5*£65",5.5,null,null,null,null,null,357.5]
["Additional operating time",null,null,null,null,null,null,null,null,""]
["Additional operating time (NHS costs)",{"$f":"561*113.6/100","v":637.29599999999994},"Costs per hour of operating time",0.5,1,null,null,null,null,318.64799999999997,"NHS Providers (https://nhsproviders.org/media/1128/operating-theatres-final.pdf) (adjusted for inflation using 2015 as base index and October 2021 index of 113.6): https://www.ons.gov.uk/economy/inflationandpriceindices/datasets/consumerpriceinflation; extra operating time = duration of HIPEC"]
["Additional operating time (Christie costs)",null,null,null,null,null,null,null,null,""]
["Consultant anaesthesist ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Anaesthetic pratictioner ",35,"cost per hour ",1,1,null,null,null,null,35,"PSSRU 2022; hospital business case"]
["Additional consultant surgeon  ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Theatre team  ",86,"cost per hour ",1,1,null,null,null,null,86,"PSSRU 2022; hospital business case"]
["Surgical assistant  ",25,"cost per hour ",1,1,null,null,null,null,25,"PSSRU 2022; hospital business case"]
["Additional operating time (Christie costs)",{"$f":"SUM(J24:J28)","v":330},"Total costs per hour of operating time (sum of costs per hour)",{"$f":"D22","v":0.5},1,null,null,null,null,165]
["Additional operating time (based on user input)",{"$f":"IF(UserInput!$B$7=\"Christie local estimates\",J29,J22)","v":318.64799999999997},"Total costs per hour of operating time (sum of costs per hour)",1,1,null,null,null,null,318.64799999999997]
["Additional hospital stay",null,null,null,null,null,null,null,null,""]
["Additional hospital stay",292,"Per night extra hospital stay",5,1,null,null,null,null,1460,"Quenet 2021; NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["HIPEC (drugs)",null,"This is based on non-reusable vials. The vial denominations were chosen to minimise the costs for the base case scenario.",null,null,null,null,null,null,""]
["Oxaliplatin  ",{"$f":"(3*591.26)+(1*295.63)+(1*178.85)","v":2248.2599999999998},"460 mg/m² in open technique and 360 mg/m² in closed technique (we assume an average of 410mg/m²)=738mg; 3 vials of 200mg (price 1 vial £591.26) + 1 vial 100mg (price 1 vial £295.63) + 1 vial 50mg (price 1 vial £178.85)",1,1,{"$f":"(460+360)/2","v":410},1.8,null,{"$f":"F34*G34","v":738},2248.2599999999998,"Quenet 2021; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["5FU Fluororacil",6.4,"400 mg/m² per patient= 720 mg; 2 vials of 500mg (price per 1 vial £6.40)",2,1,400,1.8,null,{"$f":"F35*G35","v":720},12.8,"Quenet 2021; BNF 2022;  Sacco et al 2010"]
["Folinic acid (calcium folinate)",20,"20 mg/m² per patient = 36 mg; 1 vial of 50mg (price per 1 vial £20)",1,1,20,1.8,null,{"$f":"F36*G36","v":36},20,"Quenet 2021; BNF 2022;  Sacco et al 2010"]
["Total cost of HIPEC drugs",{"$f":"SUM(J34:J36)","v":2281.06},"Total costs of HIPEC drugs (sum of HIPEC drug costs)",1,null,null,null,null,null,2281.06]
["Total costs of HIPEC",null,null,null,null,null,null,null,null,{"$f":"SUM(J11,J18,J20,J30,J32,J37)","v":5705.1289998485736}]
["CRS costs"]
["Uncomplicated CRS costs",6199,"FF50C: Complex General Abdominal Procedures with CC Score 0-2 (elective)",1,1,null,null,null,null,{"$f":"IF(D40=\"\",\"\",B40*D40*IF(E40=\"\",1,E40))","v":6199},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["Complicated CRS costs",{"$f":"(41*14857+110*8970)/151","v":10568.456953642384},"Average of FF50A: Complex General Abdominal Procedures with CC Score 6+  and FF50B:Complex General Abdominal Procedures with CC Score 3-5 (weighted by the number of procedures done based on NHS Reference costs)",1,1,null,null,null,null,{"$f":"IF(D41=\"\",\"\",B41*D41*IF(E41=\"\",1,E41))","v":10568.456953642384},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/) and NHS reference costs (https://www.england.nhs.uk/publication/2020-21-national-cost-collection-data-publication/)"]
["Systemic chemotherapy"]
["Varied systemic chemotherapy was used according to the centre. The same systemic chemotherapy was used in both arms. As we were interested in incremental costs by using the policy of HIPEC, the costs of systemic chemotherapy were not included in either arm."]

{"sheet":"CRC_HIPEC_Chem","index":2,"n_rows":46,"n_cols":11,"rows_kept":46,"cut":false,"hidden":false,"merged":[]}
["Colorectal cancer","HIPEC+CRS+systemic chemotherapy vs systemic chemotherapy"]
[null,"Unit cost ","Notes/description","Quantity per patient","Exchange rate to GBP","Total mg/m2","Surface area (m2)","Body weight (kg)","Total drug (mg per patient)","Total cost (GBP 2022)","Source"]
["HIPEC costs"]
["HIPEC machine"]
["HIPEC machine (Performer HT)",45000,"Original cost: € 45,000 + VAT. Lifelime of the machine is 10 years. Annuity factor at 5% rate. ",1,1.19,null,null,null,null,{"$f":"IF(D5=\"\",\"\",B5*D5*IF(E5=\"\",1,E5))","v":53550},"Hospital costs; Euro to GBP Exchange rate (ONS 2022)"]
["HIPEC machine service costs per year",5500,"Original cost: € 5,500. Service cost per year. This is the same regardless of volume",1,1.19,null,null,null,null,6545,"Hospital costs"]
["Life time for machine (years)",10,"Local estimate",null,null,null,null,null,null,"","Local estimate"]
["Interest rate",0.05,null,null,null,null,null,null,null,""]
["Annuity factor",{"$f":"(1-(1/(1+B8))^B7)/B8","v":7.7217349291848176},"This is calculated using the formula 1-(1/(1+interest rate))^years/interest rate",null,null,null,null,null,null,"","Drummond et al 2015 Methods for the Economic Evaluation of Health Care Programmes Edition 4"]
["Cost of HIPEC machine per year",{"$f":"(J5/B9)+J6","v":13479.969989400201},"This is calculated as: Cost of HIPEC machine/Annuity factor +HIPEC machine service costs per year (in pounds)",{"$f":"IF(OR(UserInput!$B$8=\"\",UserInput!$B$8<=70),1,ROUNDUP(QUOTIENT(UserInput!$B$8,70),0)+1)","v":1},1,null,null,null,null,13479.969989400201]
["Cost of HIPEC machine per patient",{"$f":"J10/IF(UserInput!$B$8=\"\",70,UserInput!$B$8)","v":192.5709998485743},"The machine volume per year can differ according to the number of procedures. On average, 1 machine is required for every 70 patients per year. The costs per patient are calculated as total machine costs per year/number of patients per year",1,1,null,null,null,null,192.5709998485743]
["HIPEC disposables",null,null,null,null,null,null,null,null,""]
["Hang and Go Set per case",1020,"cost per patient of consumables",1,1,null,null,null,null,1020,"Hospital costs"]
["Cytotoxic disposal per case",1.85,"cost per patient of disposable material",1,1,null,null,null,null,1.85,"Hospital costs"]
["Baxter Mitomycin",47,null,1,1,null,null,null,null,47,"Hospital costs"]
["Other Mitomycin consumables",74.37,null,1,1,null,null,null,null,74.37,"Hospital costs"]
[]
["Total cost of disposables",{"$f":"SUM(J13:J17)","v":1143.2199999999998},null,1,1,null,null,null,null,{"$f":"IF(D18=\"\",\"\",B18*D18*IF(E18=\"\",1,E18))","v":1143.2199999999998}]
["HIPEC pratitioner",null,null,null,null,null,null,null,null,""]
["HIPEC pratitioner salary (p.a)",65,"This is a pratictioner that runs and maintains the machine. The salary range here is £40,057-£45,839. Average 5.5hs per case. Assuming 47.5 hours per week, 42 weeks a year, the cost per hour is £65. Time per case is 5.5*£65",5.5,null,null,null,null,null,357.5]
["Additional operating time",null,null,null,null,null,null,null,null,""]
["Additional operating time (NHS costs)",{"$f":"561*113.6/100","v":637.29599999999994},"Costs per hour of operating time",1.5,1,null,null,null,null,955.94399999999996,"NHS Providers (https://nhsproviders.org/media/1128/operating-theatres-final.pdf) (adjusted for inflation using 2015 as base index and October 2022 index of 126.2): https://www.ons.gov.uk/economy/inflationandpriceindices/datasets/consumerpriceinflation; extra operating time = duration of HIPEC"]
["Additional operating time (Christie costs)",null,null,null,null,null,null,null,null,""]
["Consultant anaesthesist ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Anaesthetic pratictioner ",35,"cost per hour ",1,1,null,null,null,null,35,"PSSRU 2022; hospital business case"]
["Additional consultant surgeon  ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Theatre team  ",86,"cost per hour ",1,1,null,null,null,null,86,"PSSRU 2022; hospital business case"]
["Surgical assistant  ",25,"cost per hour ",1,1,null,null,null,null,25,"PSSRU 2022; hospital business case"]
["Additional operating time (Christie costs)",{"$f":"SUM(J24:J28)","v":330},"Total costs per hour of operating time (sum of costs per hour)",{"$f":"D22","v":1.5},1,null,null,null,null,495]
["Additional operating time (based on user input)",{"$f":"IF(UserInput!$B$7=\"Christie local estimates\",J29,J22)","v":955.94399999999996},"Total costs per hour of operating time (sum of costs per hour)",1,1,null,null,null,null,955.94399999999996]
["Additional hospital stay",null,null,null,null,null,null,null,null,""]
["Additional hospital stay",292,"Per night extra hospital stay",29,1,null,null,null,null,8468,"Verwaal 2003; NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["HIPEC (drugs)",null,"This is based on non-reusable vials. The vial denominations were chosen to minimise the costs for the base case scenario.",null,null,null,null,null,null,""]
["Mitomycin",{"$f":"39*3+1*20.3","v":137.30000000000001},"17.5 mg/m²  followed by 8.8 mg/m² every 30 minutes (for 90 min). The total dose was limited to 70 mg at maximum. 3 vials 20 mg at price £39 each and one 10mg at £20.30",1,1,43.900000000000006,1.8,null,{"$f":"F34*G34","v":79.02000000000001},137.30000000000001,"Verwaal 2003; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
[]
[]
["Total cost of HIPEC drugs",{"$f":"SUM(J34:J36)","v":137.30000000000001},"Total costs of HIPEC drugs (sum of HIPEC drug costs)",1,null,null,null,null,null,{"$f":"IF(D37=\"\",\"\",B37*D37*IF(E37=\"\",1,E37))","v":137.30000000000001}]
["Total costs of HIPEC",null,null,null,null,null,null,null,null,{"$f":"SUM(J11,J18,J20,J30,J32,J37)","v":11254.534999848573}]
["CRS costs"]
["Uncomplicated CRS costs",6199,"FF50C: Complex General Abdominal Procedures with CC Score 0-2 (elective)",1,1,null,null,null,null,{"$f":"IF(D40=\"\",\"\",B40*D40*IF(E40=\"\",1,E40))","v":6199},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["Complicated CRS costs",{"$f":"(41*14857+110*8970)/151","v":10568.456953642384},"Average of FF50A: Complex General Abdominal Procedures with CC Score 6+  and FF50B:Complex General Abdominal Procedures with CC Score 3-5 (weighted by the number of procedures done based on NHS Reference costs)",1,1,null,null,null,null,{"$f":"IF(D41=\"\",\"\",B41*D41*IF(E41=\"\",1,E41))","v":10568.456953642384},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/) and NHS reference costs (https://www.england.nhs.uk/publication/2020-21-national-cost-collection-data-publication/)"]
["Systemic chemotherapy"]
["5FU Fluororacil (systemic)",{"$f":"6.4*2","v":12.8},"400 mg/m² per patient= 720 mg; 2 vials of 500mg (price per 1 vial £6.40)",26,1,400,1.8,null,{"$f":"F43*G43","v":720},{"$f":"IF(D43=\"\",\"\",B43*D43*IF(E43=\"\",1,E43))","v":332.8},"Verwaal 2003; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Folinic acid (Leucovorin) systemic",{"$f":"1*37.5+1*20","v":57.5},"80mg/m² per patient = 144mg; 1 vial 100mg at price £37.50+ 1 vial 50mg at £20 each)",26,1,80,1.8,null,{"$f":"F44*G44","v":144},{"$f":"IF(D44=\"\",\"\",B44*D44*IF(E44=\"\",1,E44))","v":1495},"Verwaal 2003; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter cost 5FU",26,null,26,1,null,null,null,null,{"$f":"IF(D45=\"\",\"\",B45*D45*IF(E45=\"\",1,E45))","v":676},"Hospital costs"]
["Total costs of systemic chemotherapy",null,null,null,null,null,null,null,null,{"$f":"SUM(J43:J45)","v":2503.8000000000002}]

{"sheet":"Gastric_HIPEC_CRS","index":3,"n_rows":56,"n_cols":11,"rows_kept":56,"cut":false,"hidden":false,"merged":[]}
["Gastric cancer","HIPEC+CRS+systemic chemotherapy vs CRS+systemic chemotherapy"]
[null,"Unit cost ","Notes/description","Quantity per patient","Exchange rate to GBP","Total mg/m2","Surface area (m2)","Body weight (kg)","Total drug (mg per patient)","Total cost (GBP 2022)","Source"]
["HIPEC costs"]
["HIPEC machine"]
["HIPEC machine (Performer HT)",45000,"Original cost: € 45,000 + VAT. Lifelime of the machine is 10 years. Annuity factor at 5% rate. ",1,1.19,null,null,null,null,{"$f":"IF(D5=\"\",\"\",B5*D5*IF(E5=\"\",1,E5))","v":53550},"Hospital costs; Euro to GBP Exchange rate (ONS 2022)"]
["HIPEC machine service costs per year",5500,"Original cost: € 5,500. Service cost per year. This is the same regardless of volume",1,1.19,null,null,null,null,6545,"Hospital costs"]
["Life time for machine (years)",10,"Local estimate",null,null,null,null,null,null,"","Local estimate"]
["Interest rate",0.05,null,null,null,null,null,null,null,""]
["Annuity factor",{"$f":"(1-(1/(1+B8))^B7)/B8","v":7.7217349291848176},"This is calculated using the formula 1-(1/(1+interest rate))^years/interest rate",null,null,null,null,null,null,"","Drummond et al 2015 Methods for the Economic Evaluation of Health Care Programmes Edition 4"]
["Cost of HIPEC machine per year",{"$f":"(J5/B9)+J6","v":13479.969989400201},"This is calculated as: Cost of HIPEC machine/Annuity factor +HIPEC machine service costs per year (in pounds)",{"$f":"IF(OR(UserInput!$B$8=\"\",UserInput!$B$8<=70),1,ROUNDUP(QUOTIENT(UserInput!$B$8,70),0)+1)","v":1},1,null,null,null,null,13479.969989400201]
["Cost of HIPEC machine per patient",{"$f":"J10/IF(UserInput!$B$8=\"\",70,UserInput!$B$8)","v":192.5709998485743},"The machine volume per year can differ according to the number of procedures. On average, 1 machine is required for every 70 patients per year. The costs per patient are calculated as total machine costs per year/number of patients per year",1,1,null,null,null,null,192.5709998485743]
["HIPEC disposables",null,null,null,null,null,null,null,null,""]
["Hang and Go Set per case",1020,"cost per patient of consumables",1,1,null,null,null,null,1020,"Hospital costs"]
["Cytotoxic disposal per case",1.85,"cost per patient of disposable material",1,1,null,null,null,null,1.85,"Hospital costs"]
["Baxter Mitomycin",47,null,1,1,null,null,null,null,47,"Hospital costs"]
["Baxter Cisplatin",47,null,1,1,null,null,null,null,47,"Hospital costs"]
["Other Mitomycin consumables",74.37,null,1,1,null,null,null,null,74.37,"Hospital costs"]
["Total cost of disposables",{"$f":"SUM(J13:J17)","v":1190.2199999999998},null,1,1,null,null,null,null,1190.2199999999998]
["HIPEC pratitioner",null,null,null,null,null,null,null,null,""]
["HIPEC pratitioner salary (p.a)",65,"This is a pratictioner that runs and maintains the machine. The salary range here is £40,057-£45,839. Average 5.5hs per case. Assuming 47.5 hours per week, 42 weeks a year, the cost per hour is £65. Time per case is 5.5*£65",5.5,null,null,null,null,null,357.5]
["Additional operating time",null,null,null,null,null,null,null,null,""]
["Additional operating time (NHS costs)",{"$f":"561*113.6/100","v":637.29599999999994},"Costs per hour of operating time",1,1,null,null,null,null,637.29599999999994,"NHS Providers (https://nhsproviders.org/media/1128/operating-theatres-final.pdf) (adjusted for inflation using 2015 as base index and October 2022 index of 126.2): https://www.ons.gov.uk/economy/inflationandpriceindices/datasets/consumerpriceinflation; extra operating time = duration of HIPEC"]
["Additional operating time (Christie costs)",null,null,null,null,null,null,null,null,""]
["Consultant anaesthesist ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Anaesthetic pratictioner ",35,"cost per hour ",1,1,null,null,null,null,35,"PSSRU 2022; hospital business case"]
["Additional consultant surgeon  ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Theatre team  ",86,"cost per hour ",1,1,null,null,null,null,86,"PSSRU 2022; hospital business case"]
["Surgical assistant  ",25,"cost per hour ",1,1,null,null,null,null,25,"PSSRU 2022; hospital business case"]
["Additional operating time (Christie costs)",{"$f":"SUM(J24:J28)","v":330},"Total costs per hour of operating time (sum of costs per hour)",{"$f":"D22","v":1},1,null,null,null,null,330]
["Additional operating time (based on user input)",{"$f":"IF(UserInput!$B$7=\"Christie local estimates\",J29,J22)","v":637.29599999999994},"Total costs per hour of operating time (sum of costs per hour)",1,1,null,null,null,null,637.29599999999994]
["Additional hospital stay",null,null,null,null,null,null,null,null,""]
["Additional hospital stay",292,"Per night extra hospital stay",{"$f":"(2+3)/2","v":2.5},1,null,null,null,null,730,"There is no information on length of hospital stay. For colorectal cancer, it was 5 days more; for ovarian cancer, it was 2 days and 3 days more - a value of 2.5 was used for this analysis; NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["HIPEC (drugs)",null,"This is based on non-reusable vials. The vial denominations were chosen to minimise the costs for the base case scenario.",null,null,null,null,null,null,""]
["Mitomycin",{"$f":"39*2","v":78},"15 mg/m²  = 75 mg (2 vials 20 mg at price £39 each)",1,1,15,1.8,null,{"$f":"F34*G34","v":27},78,"Quenet 2021; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Cisplatin",{"$f":"3*24.5","v":73.5},"75 mg/m² = 135mg (3 vials 50mg at price £24.50 each )",1,1,75,1.8,null,{"$f":"F35*G35","v":135},73.5,"Quenet 2021; BNF 2022;  Sacco et al 2010"]
[]
["Total cost of HIPEC drugs",{"$f":"SUM(J34:J36)","v":151.5},"Total costs of HIPEC drugs (sum of HIPEC drug costs)",1,null,null,null,null,null,{"$f":"IF(D37=\"\",\"\",B37*D37*IF(E37=\"\",1,E37))","v":151.5}]
["Total costs of HIPEC",null,null,null,null,null,null,null,null,{"$f":"SUM(J11,J18,J20,J30,J32,J37)","v":3259.0869998485741}]
["CRS costs"]
["Uncomplicated CRS costs",6199,"FF50C: Complex General Abdominal Procedures with CC Score 0-2 (elective)",1,1,null,null,null,null,{"$f":"IF(D40=\"\",\"\",B40*D40*IF(E40=\"\",1,E40))","v":6199},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["Complicated CRS costs",{"$f":"(41*14857+110*8970)/151","v":10568.456953642384},"Average of FF50A: Complex General Abdominal Procedures with CC Score 6+  and FF50B:Complex General Abdominal Procedures with CC Score 3-5 (weighted by the number of procedures done based on NHS Reference costs)",1,1,null,null,null,null,{"$f":"IF(D41=\"\",\"\",B41*D41*IF(E41=\"\",1,E41))","v":10568.456953642384},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/) and NHS reference costs (https://www.england.nhs.uk/publication/2020-21-national-cost-collection-data-publication/)"]
["Systemic chemotherapy"]
["HER-2 negative cancers",null,null,null,null,null,null,null,null,{"$f":"IF(D43=\"\",\"\",B43*D43*IF(E43=\"\",1,E43))","v":""}]
["Epirubicin",210.76,"50mg/m2; max 100mg/d (1 vial 100mg at £201.76)",6,1,50,1.8,null,{"$f":"F44*G44","v":90},1264.56,"Rau 2022; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Oxaliplatin",{"$f":"(2*295.63)+(1*146.8)","v":738.06},"130mg/m2; max 260mg/day (2vials 100mg at£295.63; 1 vial 50mg £146.80)",6,1,130,1.8,null,{"$f":"F45*G45","v":234},4428.3599999999997,"Rau 2022; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter Oxaliplatin",47.5,null,6,1,null,null,null,null,285,"Hospital costs"]
["Capecitabine tablets (days 1-14)",{"$f":"(4*225/120+2*30/60)*14","v":119},"625mg/m2 two times a day for 14 days;  max 2500mg/day; price for 500 mg £225 120 tablets; price for 150 mg £30 60 tablets; total requirement: 4*500 mg + 2 *150 mg per day * 14 days * 6 cycles, i.e., (4*225/120+2*30/60)*14 per cycle",6,1,625,1.8,null,{"$f":"F47*G47","v":1125},714,"Hospital costs"]
["Total cost of systemic chemotherapy (HER-2 negative)",{"$f":"SUM(J44:J47)","v":6691.92},null,1,1,null,null,null,null,6691.92]
["HER-2 positive cancers",null,null,null,null,null,null,null,null,""]
["Trastuzumab",{"$f":"1*1026.66+(2*366.66)","v":1759.98},"8 mg/kg (cycles 1 & 4); (1  vial 420 at £1026.66 + 2 vials 150 at £366.66)",2,1,8,null,81,{"$f":"F50*H50","v":648},3519.96,"Rau 2022; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Trastuzumab",{"$f":"1*1026.66+(1*366.66)","v":1393.3200000000002},"6 mg/kg cycle 2,3, 4&6; (1  vial 420 at £1026.66 + 1 vial  150 at £366.66)",4,1,6,null,81,{"$f":"F51*H51","v":486},5573.2800000000007,"Rau 2022; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Cisplatin",{"$f":"3*24.5","v":73.5},"80mg/m2; max 160mg/d; (3 vials 50mg at price £24.50 each)",6,1,80,1.8,null,{"$f":"F52*G52","v":144},441,"Rau 2022; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter Cisplatin",47,null,6,1,null,null,null,null,282,"Hospital costs"]
["Capecitabine tablets (days 1-14)",{"$f":"(6*225/120+2*76.04/60)*14","v":192.98533333333333},"1000mg/m2 two times a day for 14 days;  max 4000mg/day; price for 500 mg £225 120 tablets; price for 300 mg £76.04 60 tablets; total requirement: 6*500 mg + 2 *300 mg per day * 14 days * 6 cycles, i.e., (6*225/120+2*76.04/60)*14 per cycle",6,1,1000,1.8,null,{"$f":"F54*G54","v":1800},1157.912,"Hospital costs"]
["Total cost of systemic chemotherapy (HER-2 positive)",{"$f":"SUM(J51:J54)","v":7454.1920000000009},null,1,1,null,null,null,null,7454.1920000000009]
["Total costs of systemic chemotherapy",null,"Assumption of 18% HER-2 positive gastric cancers",null,null,null,null,null,null,{"$f":"J48*0.82+J55*0.18","v":6829.12896},"Chua, T.C. and Merrett, N.D. (2012), Clinicopathologic factors associated with HER2-positive gastric cancer and its impact on survival outcomes—A systematic review. Int. J. Cancer, 130: 2845-2856. https://doi.org/10.1002/ijc.26292"]

{"sheet":"Gastric_HIPEC_Chem","index":4,"n_rows":49,"n_cols":11,"rows_kept":49,"cut":false,"hidden":false,"merged":[]}
["Gastric cancer","HIPEC+CRS+systemic chemotherapy vs systemic chemotherapy"]
[null,"Unit cost ","Notes/description","Quantity per patient","Exchange rate to GBP","Total mg/m2","Surface area (m2)","Body weight (kg)","Total drug (mg per patient)","Total cost (GBP 2022)","Source"]
["HIPEC costs"]
["HIPEC machine"]
["HIPEC machine (Performer HT)",45000,"Original cost: € 45,000 + VAT. Lifelime of the machine is 10 years. Annuity factor at 5% rate. ",1,1.19,null,null,null,null,{"$f":"IF(D5=\"\",\"\",B5*D5*IF(E5=\"\",1,E5))","v":53550},"Hospital costs; Euro to GBP Exchange rate (ONS 2022)"]
["HIPEC machine service costs per year",5500,"Original cost: € 5,500. Service cost per year. This is the same regardless of volume",1,1.19,null,null,null,null,6545,"Hospital costs"]
["Life time for machine (years)",10,"Local estimate",null,null,null,null,null,null,"","Local estimate"]
["Interest rate",0.05,null,null,null,null,null,null,null,""]
["Annuity factor",{"$f":"(1-(1/(1+B8))^B7)/B8","v":7.7217349291848176},"This is calculated using the formula 1-(1/(1+interest rate))^years/interest rate",null,null,null,null,null,null,"","Drummond et al 2015 Methods for the Economic Evaluation of Health Care Programmes Edition 4"]
["Cost of HIPEC machine per year",{"$f":"(J5/B9)+J6","v":13479.969989400201},"This is calculated as: Cost of HIPEC machine/Annuity factor +HIPEC machine service costs per year (in pounds)",{"$f":"IF(OR(UserInput!$B$8=\"\",UserInput!$B$8<=70),1,ROUNDUP(QUOTIENT(UserInput!$B$8,70),0)+1)","v":1},1,null,null,null,null,13479.969989400201]
["Cost of HIPEC machine per patient",{"$f":"J10/IF(UserInput!$B$8=\"\",70,UserInput!$B$8)","v":192.5709998485743},"The machine volume per year can differ according to the number of procedures. On average, 1 machine is required for every 70 patients per year. The costs per patient are calculated as total machine costs per year/number of patients per year",1,1,null,null,null,null,192.5709998485743]
["HIPEC disposables",null,null,null,null,null,null,null,null,""]
["Hang and Go Set per case",1020,"cost per patient of consumables",1,1,null,null,null,null,1020,"Hospital costs"]
["Cytotoxic disposal per case",1.85,"cost per patient of disposable material",1,1,null,null,null,null,1.85,"Hospital costs"]
["Baxter cost Oxaliplatin",47.5,null,1,1,null,null,null,null,47.5,"Hospital costs"]
["Baxter cost 5FU",26,null,1,1,null,null,null,null,26,"Hospital costs"]
[]
["Total cost of disposables",{"$f":"SUM(J13:J17)","v":1095.3499999999999},null,1,1,null,null,null,null,{"$f":"IF(D18=\"\",\"\",B18*D18*IF(E18=\"\",1,E18))","v":1095.3499999999999}]
["HIPEC pratitioner",null,null,null,null,null,null,null,null,""]
["HIPEC pratitioner salary (p.a)",65,"This is a pratictioner that runs and maintains the machine. The salary range here is £40,057-£45,839. Average 5.5hs per case. Assuming 47.5 hours per week, 42 weeks a year, the cost per hour is £65. Time per case is 5.5*£65",5.5,null,null,null,null,null,357.5]
["Additional operating time",null,null,null,null,null,null,null,null,""]
["Additional operating time (NHS costs)",{"$f":"561*113.6/100","v":637.29599999999994},"Costs per hour of operating time",0.5,1,null,null,null,null,318.64799999999997,"NHS Providers (https://nhsproviders.org/media/1128/operating-theatres-final.pdf) (adjusted for inflation using 2015 as base index and October 2022 index of 126.2): https://www.ons.gov.uk/economy/inflationandpriceindices/datasets/consumerpriceinflation; extra operating time = duration of HIPEC"]
["Additional operating time (Christie costs)",null,null,null,null,null,null,null,null,""]
["Consultant anaesthesist ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Anaesthetic pratictioner ",35,"cost per hour ",1,1,null,null,null,null,35,"PSSRU 2022; hospital business case"]
["Additional consultant surgeon  ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Theatre team  ",86,"cost per hour ",1,1,null,null,null,null,86,"PSSRU 2022; hospital business case"]
["Surgical assistant  ",25,"cost per hour ",1,1,null,null,null,null,25,"PSSRU 2022; hospital business case"]
["Additional operating time (Christie costs)",{"$f":"SUM(J24:J28)","v":330},"Total costs per hour of operating time (sum of costs per hour)",{"$f":"D22","v":0.5},1,null,null,null,null,165]
["Additional operating time (based on user input)",{"$f":"IF(UserInput!$B$7=\"Christie local estimates\",J29,J22)","v":318.64799999999997},"Total costs per hour of operating time (sum of costs per hour)",1,1,null,null,null,null,318.64799999999997]
["Additional hospital stay",null,null,null,null,null,null,null,null,""]
["Additional hospital stay",292,"Per night extra hospital stay",17,1,null,null,null,null,4964,"Rudloff 2014; NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["HIPEC (drugs)",null,"This is based on non-reusable vials. The vial denominations were chosen to minimise the costs for the base case scenario.",null,null,null,null,null,null,""]
["Oxaliplatin  ",{"$f":"(4*591.26)+(1*178.85)","v":2543.89},"460 mg/m² in closed circuit=828mg; 4 vials of 200mg (price 1 vial £591.26) + 1 vial 50mg (price 1 vial £178.85)",1,1,460,1.8,null,{"$f":"F34*G34","v":828},2543.89,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["5FU Fluororacil",{"$f":"2*6.4","v":12.8},"400 mg/m² per patient= 720 mg; 2 vials of 500mg (price per 1 vial £6.40)",1,1,400,1.8,null,{"$f":"F35*G35","v":720},12.8,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Folinic acid Leucovorin",20,"20 mg/m² per patient = 36 mg; 1 vial of 50mg (price per 1 vial £20)",1,1,20,1.8,null,{"$f":"F36*G36","v":36},20,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Total cost of HIPEC drugs",{"$f":"SUM(J34:J36)","v":2576.69},"Total costs of HIPEC drugs (sum of HIPEC drug costs)",1,null,null,null,null,null,2576.69]
["Total costs of HIPEC",null,null,null,null,null,null,null,null,{"$f":"SUM(J11,J18,J20,J30,J32,J37)","v":9504.7589998485746}]
["CRS costs"]
["Uncomplicated CRS costs",6199,"FF50C: Complex General Abdominal Procedures with CC Score 0-2 (elective)",1,1,null,null,null,null,{"$f":"IF(D40=\"\",\"\",B40*D40*IF(E40=\"\",1,E40))","v":6199},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["Complicated CRS costs",{"$f":"(41*14857+110*8970)/151","v":10568.456953642384},"Average of FF50A: Complex General Abdominal Procedures with CC Score 6+  and FF50B:Complex General Abdominal Procedures with CC Score 3-5 (weighted by the number of procedures done based on NHS Reference costs)",1,1,null,null,null,null,{"$f":"IF(D41=\"\",\"\",B41*D41*IF(E41=\"\",1,E41))","v":10568.456953642384},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/) and NHS reference costs (https://www.england.nhs.uk/publication/2020-21-national-cost-collection-data-publication/)"]
["Systemic chemotherapy"]
["Irinotecan ",110," 165mg/m2 administer 90 min = 297mg (1 vial 300mg at  £110)",12,1,165,1.8,null,{"$f":"F43*G43","v":297},{"$f":"IF(D43=\"\",\"\",B43*D43*IF(E43=\"\",1,E43))","v":1320},"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Oxaliplatin  ",591.26,"over 2 hours 85 mg/m²  =153mg; 1 vials of 200mg (price 1 vial £591.26)  ",12,1,85,1.8,null,{"$f":"F44*G44","v":153},7095.12,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter Oxaliplatin",47.5,null,12,1,null,null,null,null,570,"Hospital costs"]
["Folinic acid Leucovorin",{"$f":"(1*39/5)+(1*139.52)","v":147.32000000000002},"over  hours 200 mg/m² per patient = 360 mg; 1 vial of 350mg (price per 1 vial £139.52) + 1 vial 15mg (£39 for 5 vials)",12,1,200,1.8,null,{"$f":"F46*G46","v":360},1767.8400000000001,"Hospital costs"]
["5FU Fluororacil",{"$f":"1*64+1*32","v":96},"over 48 hours 3200 mg/m² per patient= 5760 mg; 1 vials of 5g (price per 1 vial £64) +  1 vial 2.5g at £32",12,1,3200,1.8,null,{"$f":"F47*G47","v":5760},1152,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter cost 5FU",26,null,12,1,null,null,null,null,312,"Rudloff 2014; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Total cost of systemic chemotherapy",null,null,null,null,null,null,null,null,{"$f":"SUM(J43:J48)","v":12216.96}]

{"sheet":"Ovarian_HIPEC_CRS","index":5,"n_rows":46,"n_cols":11,"rows_kept":46,"cut":false,"hidden":false,"merged":[]}
["Ovarian cancer","HIPEC+CRS+systemic chemotherapy vs CRS+systemic chemotherapy"]
[null,"Unit cost ","Notes/description","Quantity per patient","Exchange rate to GBP","Total mg/m2","Surface area (m2)","Body weight (kg)","Total drug (mg per patient)","Total cost (GBP 2022)","Source"]
["HIPEC costs"]
["HIPEC machine"]
["HIPEC machine (Performer HT)",45000,"Original cost: € 45,000 + VAT. Lifelime of the machine is 10 years. Annuity factor at 5% rate. ",1,1.19,null,null,null,null,{"$f":"IF(D5=\"\",\"\",B5*D5*IF(E5=\"\",1,E5))","v":53550},"Hospital costs; Euro to GBP Exchange rate (ONS 2022)"]
["HIPEC machine service costs per year",5500,"Original cost: € 5,500. Service cost per year. This is the same regardless of volume",1,1.19,null,null,null,null,6545,"Hospital costs"]
["Life time for machine (years)",10,"Local estimate",null,null,null,null,null,null,"","Local estimate"]
["Interest rate",0.05,null,null,null,null,null,null,null,""]
["Annuity factor",{"$f":"(1-(1/(1+B8))^B7)/B8","v":7.7217349291848176},"This is calculated using the formula 1-(1/(1+interest rate))^years/interest rate",null,null,null,null,null,null,"","Drummond et al 2015 Methods for the Economic Evaluation of Health Care Programmes Edition 4"]
["Cost of HIPEC machine per year",{"$f":"(J5/B9)+J6","v":13479.969989400201},"This is calculated as: Cost of HIPEC machine/Annuity factor +HIPEC machine service costs per year (in pounds)",{"$f":"IF(OR(UserInput!$B$8=\"\",UserInput!$B$8<=70),1,ROUNDUP(QUOTIENT(UserInput!$B$8,70),0)+1)","v":1},1,null,null,null,null,13479.969989400201]
["Cost of HIPEC machine per patient",{"$f":"J10/IF(UserInput!$B$8=\"\",70,UserInput!$B$8)","v":192.5709998485743},"The machine volume per year can differ according to the number of procedures. On average, 1 machine is required for every 70 patients per year. The costs per patient are calculated as total machine costs per year/number of patients per year",1,1,null,null,null,null,192.5709998485743]
["HIPEC disposables",null,null,null,null,null,null,null,null,""]
["Hang and Go Set per case",1020,"cost per patient of consumables",1,1,null,null,null,null,1020,"Hospital costs"]
["Cytotoxic disposal per case",1.85,"cost per patient of disposable material",1,1,null,null,null,null,1.85,"Hospital costs"]
["Baxter cost Cisplatin",47,null,1,1,null,null,null,null,47,"Hospital costs"]
[]
[]
["Total cost of disposables",{"$f":"SUM(J13:J17)","v":1068.8499999999999},null,1,1,null,null,null,null,{"$f":"IF(D18=\"\",\"\",B18*D18*IF(E18=\"\",1,E18))","v":1068.8499999999999}]
["HIPEC pratitioner",null,null,null,null,null,null,null,null,""]
["HIPEC pratitioner salary (p.a)",65,"This is a pratictioner that runs and maintains the machine. The salary range here is £40,057-£45,839. Average 5.5hs per case. Assuming 47.5 hours per week, 42 weeks a year, the cost per hour is £65. Time per case is 5.5*£65",5.5,null,null,null,null,null,357.5]
["Additional operating time",null,null,null,null,null,null,null,null,""]
["Additional operating time (NHS costs)",{"$f":"561*113.6/100","v":637.29599999999994},"Costs per hour of operating time",1.5,1,null,null,null,null,955.94399999999996,"NHS Providers (https://nhsproviders.org/media/1128/operating-theatres-final.pdf) (adjusted for inflation using 2015 as base index and October 2022 index of 126.2): https://www.ons.gov.uk/economy/inflationandpriceindices/datasets/consumerpriceinflation; extra operating time = duration of HIPEC"]
["Additional operating time (Christie costs)",null,null,null,null,null,null,null,null,""]
["Consultant anaesthesist ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Anaesthetic pratictioner ",35,"cost per hour ",1,1,null,null,null,null,35,"PSSRU 2022; hospital business case"]
["Additional consultant surgeon  ",92,"cost per hour ",1,1,null,null,null,null,92,"PSSRU 2022; hospital business case"]
["Theatre team  ",86,"cost per hour ",1,1,null,null,null,null,86,"PSSRU 2022; hospital business case"]
["Surgical assistant  ",25,"cost per hour ",1,1,null,null,null,null,25,"PSSRU 2022; hospital business case"]
["Additional operating time (Christie costs)",{"$f":"SUM(J24:J28)","v":330},"Total costs per hour of operating time (sum of costs per hour)",{"$f":"D22","v":1.5},1,null,null,null,null,495]
["Additional operating time (based on user input)",{"$f":"IF(UserInput!$B$7=\"Christie local estimates\",J29,J22)","v":955.94399999999996},"Total costs per hour of operating time (sum of costs per hour)",1,1,null,null,null,null,955.94399999999996]
["Additional hospital stay",null,null,null,null,null,null,null,null,""]
["Additional hospital stay",292,"Per night extra hospital stay",{"$f":"(2+3)/2","v":2.5},1,null,null,null,null,730,"van Driel 2018 & Lim 2022; NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["HIPEC (drugs)",null,"This is based on non-reusable vials. The vial denominations were chosen to minimise the costs for the base case scenario.",null,null,null,null,null,null,""]
["Cisplatin",{"$f":"3*24.5","v":73.5},"100 mg/m² = 180mg (3 vials 50mg at price £24.50 each )",1,1,100,1.8,null,{"$f":"F34*G34","v":180},73.5,"van Driel 2018; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Sodium Thiosulphate",143,"9mg/m2+12g/m2=21 g/m2 (3 vials of 12.5 mg at £143 each)",1,1,21,1.8,null,{"$f":"F35*G35","v":37.800000000000004},143,"Hospital costs"]
[]
["Total cost of HIPEC drugs",{"$f":"SUM(J34:J36)","v":216.5},"Total costs of HIPEC drugs (sum of HIPEC drug costs)",1,null,null,null,null,null,{"$f":"IF(D37=\"\",\"\",B37*D37*IF(E37=\"\",1,E37))","v":216.5}]
["Total costs of HIPEC",null,null,null,null,null,null,null,null,{"$f":"SUM(J11,J18,J20,J30,J32,J37)","v":3521.3649998485744}]
["CRS costs"]
["Uncomplicated CRS costs",6199,"FF50C: Complex General Abdominal Procedures with CC Score 0-2 (elective)",1,1,null,null,null,null,{"$f":"IF(D40=\"\",\"\",B40*D40*IF(E40=\"\",1,E40))","v":6199},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/)"]
["Complicated CRS costs",{"$f":"(41*14857+110*8970)/151","v":10568.456953642384},"Average of FF50A: Complex General Abdominal Procedures with CC Score 6+  and FF50B:Complex General Abdominal Procedures with CC Score 3-5 (weighted by the number of procedures done based on NHS Reference costs)",1,1,null,null,null,null,{"$f":"IF(D41=\"\",\"\",B41*D41*IF(E41=\"\",1,E41))","v":10568.456953642384},"NHS tariffs November 2022 (https://www.england.nhs.uk/publication/national-tariff-payment-system-documents-annexes-and-supporting-documents/) and NHS reference costs (https://www.england.nhs.uk/publication/2020-21-national-cost-collection-data-publication/)"]
["Systemic chemotherapy"]
["Carboplatin ",20.2,"(5-6mg/minute); we assume a total of 5mg/m2 in total; 9mg (1 vial 50mg at £20.20)",6,1,5,1.8,null,{"$f":"F43*G43","v":9},{"$f":"IF(D43=\"\",\"\",B43*D43*IF(E43=\"\",1,E43))","v":121.19999999999999},"van Driel 2018; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Paclitaxel",{"$f":"35+192.5","v":227.5},"175 mg/m2 = 315mg (1 vial 300mg at £192.50 + 1 vial 30mg at £35)",6,1,175,1.8,null,{"$f":"F44*G44","v":315},{"$f":"IF(D44=\"\",\"\",B44*D44*IF(E44=\"\",1,E44))","v":1365},"van Driel 2018; BNF 2022;  Sacco et al 2010 (Sacco JJ, Botten J, Macbeth F, Bagust A, Clark P. The average body surface area of adult cancer patients in the UK: a multicentre retrospective study. PLoS One. 2010 Jan 28;5(1):e8933. doi: 10.1371/journal.pone.0008933. PMID: 20126669; PMCID: PMC2812484)."]
["Baxter carboplatin",47,null,6,1,null,null,null,null,{"$f":"IF(D45=\"\",\"\",B45*D45*IF(E45=\"\",1,E45))","v":282},"Hospital costs"]
["Total cost of systemic chemotherapy",null,null,1,1,null,null,null,null,{"$f":"SUM(J43:J45)","v":1768.2}]

{"sheet":"SourceData","index":6,"n_rows":34,"n_cols":37,"rows_kept":34,"cut":false,"hidden":false,"merged":[]}
["Short-term","Days","Source",null,null,null,null,null,"Chosen category","Variable","Distribution","Colorectal cancer (HIPEC + CRS vs CRS)",null,null,null,null,"Colorectal cancer (HIPEC + CRS vs chemotherapy)",null,null,null,null,"Gastric cancer (HIPEC + CRS vs CRS)",null,null,null,null,"Gastric cancer (HIPEC + CRS vs chemotherapy)",null,null,null,null,"Ovarian cancer (HIPEC + CRS vs CRS)",null,null,null,null," "]
["Colorectal cancer (HIPEC + CRS vs CRS)",30,"Quenet et al",null,null,null,null,null,{"$f":"IF(UserInput!B4=\"\",1,IF(UserInput!B4=\"Ovarian cancer\",5,IF(UserInput!B4=\"Colorectal cancer\",IF(UserInput!B6=\"Chemotherapy without CRS\",2,1),IF(UserInput!B6=\"Chemotherapy without CRS\",4,3))))","v":5},"Complications (HIPEC + CRS)","Beta",34,{"$f":"133-L2","v":99},0,0.5,"Systematic review (from: Quenet et al)",34,{"$f":"133-Q2","v":99},0,0.5,"No information from Verwaal et al; therefore used details from Quenet et al",5,{"$f":"34-V2","v":29},0,0.5,"Systematic review (from: Yang et al)",5,{"$f":"34-AA2","v":29},0,0.5,"No information from Rudloff et al; therefore used details from Yang et al",42,{"$f":"157-AF2","v":115},0,0.5,"Systematic review (from: van Driel et al and Antonia et al)"," "]
["Colorectal cancer (HIPEC + CRS vs systemic chemotherapy)",30,"Verwaal et al",null,null,null,null,null,"Offset column","Short-term mortality (HIPEC + CRS)","Beta",2,{"$f":"133-L3","v":131},0,0.1,"Quenet et al",4,{"$f":"54-Q3","v":50},0,0.1,"Verwaal et al",0,{"$f":"34-V3","v":34},0,0.1,"No information",0,{"$f":"9-AA3","v":9},0,0.1,"Rudloff et al",1,{"$f":"157-AF3","v":156},0,0.1,"From: van Driel et al and Antonia et al"," "]
["Gastric cancer (HIPEC + CRS vs CRS)","Not applicable","Yang et al",null,null,null,null,null,{"$f":"(I2-1)*5","v":20},"Survival ln (hazard ratio)","Continuous",{"$f":"G16","v":0},{"$f":"H16","v":0.23456051077673365},-2,2,"Systematic review (from: Quenet et al)",{"$f":"G17","v":-0.59783700075562041},{"$f":"H17","v":0.27759208775873734},-2,2,"Systematic review (from: Verwaal et al)",{"$f":"G18","v":-0.44628710262841947},{"$f":"H18","v":0.47829306832353347},-2,2,"Systematic review (from: Yang et al)",{"$f":"G19","v":-0.916290731874155},{"$f":"H19","v":0.14032052151416241},-2,2,"Systematic review (from: Rudloff et al)",{"$f":"G20","v":-0.31471074483970024},{"$f":"H20","v":0.12488704618559321},-2,2,"Systematic review (from: van Driel et al, Antonia et al, Lim et al)"," "]
["Gastric cancer (HIPEC + CRS vs systemic chemotherapy)",30,"Rudloff et al",null,null,null,null,null,null,"Complications (Control)","Beta",20,{"$f":"132-L5","v":112},0,0.5,"Systematic review (from: Quenet et al)",{"$f":"ROUND(0.19*51,0)","v":10},{"$f":"51-Q5","v":41},0,0.5,"Estimated from Verwaal et al",4,{"$f":"34-V5","v":30},0,0.5,"Systematic review (from: Yang et al)",0,{"$f":"8-AA5","v":8},0,0.5,"No information",40,{"$f":"159-AF5","v":119},0,0.5,"Systematic review (from: van Driel et al and Antonia et al)"," "]
["Ovarian cancer (HIPEC + CRS vs CRS)",30,"van Driel et al, Antonia et al",null,null,null,null,null,null,"Short-term mortality (Control)","Beta",2,{"$f":"132-L6","v":130},0,0.1,"Quenet et al",0,{"$f":"51-Q6","v":51},0,0.1,"Verwaal et al",0,{"$f":"34-V6","v":34},0,0.1,"No information",0,{"$f":"8-AA6","v":8},0,0.1,"No information",2,{"$f":"159-AF6","v":157},0,0.1,"From: van Driel et al and Antonia et al"," "]
["Medium term","Years",null,null,null,null,null,null,null,"5-year mortality (Control)","Beta",80,{"$f":"133-L7","v":53},0,1,"Systematic review (from: Quenet et al)",80,{"$f":"133-Q7","v":53},0,1,"Systematic review (from: Verwaal et al)",33,{"$f":"34-V7","v":1},0,1,"Systematic review (from: Yang et al)",8,{"$f":"8-AA7","v":0},0,1,"Systematic review (from: Rudloff et al)",123,{"$f":"215-AF7","v":92},0,1,"Systematic review (from: van Driel et al and Lim et al). The number of deaths was reported only in these two trials, but the hazard ratios were reported in the three trials"," "]
["Colorectal cancer (HIPEC + CRS vs CRS)",5,"Quenet et al",null,null,null,null,null,null,"Cost (HIPEC + CRS) Complicated","Uniform",{"$f":"C23+E23+F23","v":16273.585953490958},null,{"$f":"L8*0.7","v":11391.51016744367},{"$f":"L8*1.3","v":21155.661739538245},"See Sheet 'CRC_HIPEC_CRS'",{"$f":"C24+E24+F24","v":24326.791953490956},null,{"$f":"Q8*0.7","v":17028.754367443667},{"$f":"Q8*1.3","v":31624.829539538245},"See Sheet 'CRC_HIPEC_Chem'",{"$f":"C25+E25+F25","v":20656.672913490958},null,{"$f":"V8*0.7","v":14459.67103944367},{"$f":"V8*1.3","v":26853.674787538246},"See Sheet 'Gastric_HIPEC_CRS'",{"$f":"C26+E26+F26","v":32290.175953490958},null,{"$f":"AA8*0.7","v":22603.123167443668},{"$f":"AA8*1.3","v":41977.228739538245},"See Sheet 'Gastric_HIPEC_Chemo'",{"$f":"C27+E27+F27","v":15858.021953490959},null,{"$f":"AF8*0.7","v":11100.61536744367},{"$f":"AF8*1.3","v":20615.428539538247},"See Sheet 'Ovarian_HIPEC_CRS'"," "]
["Colorectal cancer (HIPEC + CRS vs systemic chemotherapy)",2,"Verwaal et al",null,null,null,null,null,null,"Cost (HIPEC + CRS) Uncomplicated","Uniform",{"$f":"C23+D23+F23","v":11904.128999848574},null,{"$f":"L9*0.7","v":8332.8902998940011},{"$f":"L9*1.3","v":15475.367699803146},"See Sheet 'CRC_HIPEC_CRS'",{"$f":"C24+D24+F24","v":19957.334999848572},null,{"$f":"Q9*0.7","v":13970.134499894},{"$f":"Q9*1.3","v":25944.535499803143},"See Sheet 'CRC_HIPEC_Chem'",{"$f":"C25+D25+F25","v":16287.215959848574},null,{"$f":"V9*0.7","v":11401.051171894002},{"$f":"V9*1.3","v":21173.380747803149},"See Sheet 'Gastric_HIPEC_CRS'",{"$f":"C26+D26+F26","v":27920.718999848574},null,{"$f":"AA9*0.7","v":19544.503299894001},{"$f":"AA9*1.3","v":36296.934699803147},"See Sheet 'Gastric_HIPEC_Chemo'",{"$f":"C27+D27+F27","v":11488.564999848575},null,{"$f":"AF9*0.7","v":8041.995499894002},{"$f":"AF9*1.3","v":14935.134499803147},"See Sheet 'Ovarian_HIPEC_CRS'"," "]
["Gastric cancer (HIPEC + CRS vs CRS)",3,"Yang et al",null,null,null,null,null,null,"Cost (Control) Complicated","Uniform",{"$f":"E23+F23","v":10568.456953642384},null,{"$f":"L10*0.7","v":7397.9198675496682},{"$f":"L10*1.3","v":13738.9940397351},"See Sheet 'CRC_HIPEC_CRS'",{"$f":"E24+F24","v":13072.256953642383},null,{"$f":"Q10*0.7","v":9150.5798675496681},{"$f":"Q10*1.3","v":16993.934039735101},"See Sheet 'CRC_HIPEC_Chem'",{"$f":"E25+F25","v":17397.585913642382},null,{"$f":"V10*0.7","v":12178.310139549667},{"$f":"V10*1.3","v":22616.861687735098},"See Sheet 'Gastric_HIPEC_CRS'",{"$f":"E26+F26","v":22785.416953642383},null,{"$f":"AA10*0.7","v":15949.791867549668},{"$f":"AA10*1.3","v":29621.042039735101},"See Sheet 'Gastric_HIPEC_Chemo'",{"$f":"E27+F27","v":12336.656953642385},null,{"$f":"AF10*0.7","v":8635.659867549668},{"$f":"AF10*1.3","v":16037.654039735102},"See Sheet 'Ovarian_HIPEC_CRS'"," "]
["Gastric cancer (HIPEC + CRS vs systemic chemotherapy)",2,"Rudloff et al",null,null,null,null,null,null,"Cost (Control) Uncomplicated","Uniform",{"$f":"D23+F23","v":6199},null,{"$f":"L11*0.7","v":4339.2999999999993},{"$f":"L11*1.3","v":8058.7000000000007},"See Sheet 'CRC_HIPEC_CRS'",{"$f":"D24+F24","v":8702.7999999999993},null,{"$f":"Q11*0.7","v":6091.9599999999991},{"$f":"Q11*1.3","v":11313.64},"See Sheet 'CRC_HIPEC_Chem'",{"$f":"D25+F25","v":13028.12896},null,{"$f":"V11*0.7","v":9119.6902719999998},{"$f":"V11*1.3","v":16936.567648},"See Sheet 'Gastric_HIPEC_CRS'",{"$f":"D26+F26","v":18415.96},null,{"$f":"AA11*0.7","v":12891.171999999999},{"$f":"AA11*1.3","v":23940.748},"See Sheet 'Gastric_HIPEC_Chemo'",{"$f":"D27+F27","v":7967.2},null,{"$f":"AF11*0.7","v":5577.04},{"$f":"AF11*1.3","v":10357.36},"See Sheet 'Ovarian_HIPEC_CRS'"," "]
["Ovarian cancer (HIPEC + CRS vs CRS)",4,"van Driel et al, Antonia et al, Lim et al",null,null,null,null,null,null,"QoL (complicated HIPEC + CRS) (Short-term)","Beta",{"$f":"L13-0.1","v":0.43000000000000005},{"$f":"1-L12","v":0.56999999999999995},0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"Q13-0.1","v":0.43000000000000005},{"$f":"1-Q12","v":0.56999999999999995},0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"V13-0.1","v":0.43000000000000005},{"$f":"1-V12","v":0.56999999999999995},0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"AA13-0.1","v":0.43000000000000005},{"$f":"1-AA12","v":0.56999999999999995},0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"AF13-0.1","v":0.50129999999999997},{"$f":"1-AF12","v":0.49870000000000003},0.1,0.9,"Hypothetical 0.1 less in complicated"," "]
[null,null,null,null,null,null,null,null,null,"QoL (uncomplicated HIPEC + CRS) (Short-term)","Beta",0.53,0.47,0.1,0.9,"Leimkühler M, Hentzen JEKR, Hemmer PHJ, Been LB, van Ginkel RJ, Kruijff S, van Leeuwen BL, de Bock GH. Systematic Review of Factors Affecting Quality of Life After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 Oct;27(10):3973-3983. doi: 10.1245/s10434-020-08379-9. Epub 2020 Apr 26. PMID: 32335752; PMCID: PMC7471142; EORTC CLQ-30 mapped to EQ5D using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. Based on this, the range of EQ5D is 0.4 to 0.63.",0.53,0.47,0.1,0.9,"Leimkühler M, Hentzen JEKR, Hemmer PHJ, Been LB, van Ginkel RJ, Kruijff S, van Leeuwen BL, de Bock GH. Systematic Review of Factors Affecting Quality of Life After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 Oct;27(10):3973-3983. doi: 10.1245/s10434-020-08379-9. Epub 2020 Apr 26. PMID: 32335752; PMCID: PMC7471142; EORTC CLQ-30 mapped to EQ5D using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. Based on this, the range of EQ5D is 0.4 to 0.63.",0.53,0.47,0.1,0.9,"Leimkühler M, Hentzen JEKR, Hemmer PHJ, Been LB, van Ginkel RJ, Kruijff S, van Leeuwen BL, de Bock GH. Systematic Review of Factors Affecting Quality of Life After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 Oct;27(10):3973-3983. doi: 10.1245/s10434-020-08379-9. Epub 2020 Apr 26. PMID: 32335752; PMCID: PMC7471142; EORTC CLQ-30 mapped to EQ5D using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. Based on this, the range of EQ5D is 0.4 to 0.63.",0.53,0.47,0.1,0.9,"Leimkühler M, Hentzen JEKR, Hemmer PHJ, Been LB, van Ginkel RJ, Kruijff S, van Leeuwen BL, de Bock GH. Systematic Review of Factors Affecting Quality of Life After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 Oct;27(10):3973-3983. doi: 10.1245/s10434-020-08379-9. Epub 2020 Apr 26. PMID: 32335752; PMCID: PMC7471142; EORTC CLQ-30 mapped to EQ5D using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. Based on this, the range of EQ5D is 0.4 to 0.63.",0.60129999999999995,0.39870000000000005,0.1,0.9,"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (3 months)"," "]
["Calculations",null,null,null,null,null,null,null,null,"QoL (Complicated CRS) (Short-term)","Beta",{"$f":"L15-0.1","v":0.43000000000000005},0.56999999999999995,0.1,0.9,"Hypothetically same as HIPEC group",{"$f":"Q15-0.1","v":0.57000000000000006},0.42999999999999994,0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"V15-0.1","v":0.43000000000000005},0.56999999999999995,0.1,0.9,"Hypothetically same as HIPEC group",{"$f":"AA15-0.1","v":0.54},0.45999999999999996,0.1,0.9,"Hypothetical 0.1 less in complicated",{"$f":"AF15-0.1","v":0.50461200000000006},0.49538799999999994,0.1,0.9,"Hypothetical 0.1 less in complicated"," "]
["Hazard ratio to Ln hazard ratio","Hazard ratio","Point estimate","Lower CI","Upper CI","CI","lnHR","SELnHR",null,"QoL (Uncomplicated CRS) (Short-term)","Beta",0.53,0.47,0.1,0.9,"Hypothetically same as HIPEC group",0.67,0.32999999999999996,0.1,0.9,"Flyum IR, Mahic S, Grov EK, Joranger P. Health-related quality of life in patients with colorectal cancer in the palliative phase: a systematic review and meta-analysis. BMC Palliat Care. 2021 Sep 16;20(1):144. doi: 10.1186/s12904-021-00837-9. PMID: 34530833; PMCID: PMC8447559",0.53,0.47,0.1,0.9,"Hypothetically same as HIPEC group",0.64,0.36,0.1,0.9,"Carter GC, King DT, Hess LM, Mitchell SA, Taipale KL, Kiiskinen U, Rajan N, Novick D, Liepa AM. Health state utility values associated with advanced gastric, oesophageal, or gastro-oesophageal junction adenocarcinoma: a systematic review. J Med Econ. 2015;18(11):954-66. doi: 10.3111/13696998.2015.1066380. Epub 2015 Sep 11. PMID: 26212479 (gastric cancer: range 0.55 to 0.73)",0.60461200000000004,0.39538799999999996,0.1,0.9,"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (3 months)"," "]
["Colorectal cancer (HIPEC + CRS vs CRS)","1.00 [0.63, 1.58]",{"$f":"VALUE(LEFT($B16,FIND(\"[\",$B16)-2))","v":1},{"$f":"VALUE(MID($B16,FIND(\"[\",$B16)+1,FIND(\",\",$B16)-FIND(\"[\",$B16)-1))","v":0.63},{"$f":"VALUE(MID($B16,FIND(\",\",$B16)+1,FIND(\"]\",$B16)-FIND(\",\",$B16)-1))","v":1.58},0.95,{"$f":"IF(C16=\"\",\"\",LN(C16))","v":0},{"$f":"IF(OR(E16=\"\",D16=\"\",F16=\"\"),\"\", (LN(E16)-LN(D16))/(2*-NORMSINV((1-F16)/2)))","v":0.23456051077673365},null,"QoL (Long-term) HIPEC","Beta",0.78500000000000003,0.21499999999999997,0.1,0.9,"Malcolm FL, Adiamah A, Banerjea A, Whitehead D, Gupta A, West J, Humes DJ: Long-term health-related quality of life following colorectal cancer surgery: patient-reported outcomes in a remote follow-up population. Colorectal Dis 2021, 23(1):213-225",0.78500000000000003,0.21499999999999997,0.1,0.9,"Malcolm FL, Adiamah A, Banerjea A, Whitehead D, Gupta A, West J, Humes DJ: Long-term health-related quality of life following colorectal cancer surgery: patient-reported outcomes in a remote follow-up population. Colorectal Dis 2021, 23(1):213-225",0.85,0.15000000000000002,0.1,0.9,"van der Wielen, N., et al. (2022). \"Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial.\" Eur J Surg Oncol 48(3): 553-560",0.85,0.15000000000000002,0.1,0.9,"van der Wielen, N., et al. (2022). \"Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial.\" Eur J Surg Oncol 48(3): 553-560",0.60599999999999998,0.39400000000000002,0.1,0.9,"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (12 months)"," "]
["Colorectal cancer (HIPEC + CRS vs systemic chemotherapy)","0.55 [0.32, 0.95]",{"$f":"VALUE(LEFT($B17,FIND(\"[\",$B17)-2))","v":0.55000000000000004},{"$f":"VALUE(MID($B17,FIND(\"[\",$B17)+1,FIND(\",\",$B17)-FIND(\"[\",$B17)-1))","v":0.32},{"$f":"VALUE(MID($B17,FIND(\",\",$B17)+1,FIND(\"]\",$B17)-FIND(\",\",$B17)-1))","v":0.95},0.95,{"$f":"IF(C17=\"\",\"\",LN(C17))","v":-0.59783700075562041},{"$f":"IF(OR(E17=\"\",D17=\"\",F17=\"\"),\"\", (LN(E17)-LN(D17))/(2*-NORMSINV((1-F17)/2)))","v":0.27759208775873734},null,"QoL (Long-term) Control","Beta",0.78500000000000003,0.21499999999999997,0.1,0.9,"Malcolm FL, Adiamah A, Banerjea A, Whitehead D, Gupta A, West J, Humes DJ: Long-term health-related quality of life following colorectal cancer surgery: patient-reported outcomes in a remote follow-up population. Colorectal Dis 2021, 23(1):213-225",0.67,0.32999999999999996,0.1,0.9,"Flyum IR, Mahic S, Grov EK, Joranger P. Health-related quality of life in patients with colorectal cancer in the palliative phase: a systematic review and meta-analysis. BMC Palliat Care. 2021 Sep 16;20(1):144. doi: 10.1186/s12904-021-00837-9. PMID: 34530833; PMCID: PMC8447559",0.85,0.15000000000000002,0.1,0.9,"van der Wielen, N., et al. (2022). \"Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial.\" Eur J Surg Oncol 48(3): 553-560",0.64,0.36,0.1,0.9,"Carter GC, King DT, Hess LM, Mitchell SA, Taipale KL, Kiiskinen U, Rajan N, Novick D, Liepa AM. Health state utility values associated with advanced gastric, oesophageal, or gastro-oesophageal junction adenocarcinoma: a systematic review. J Med Econ. 2015;18(11):954-66. doi: 10.3111/13696998.2015.1066380. Epub 2015 Sep 11. PMID: 26212479 (gastric cancer: range 0.55 to 0.73)",0.60599999999999998,0.39400000000000002,0.1,0.9,"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (12 months)"," "]
["Gastric cancer (HIPEC + CRS vs CRS)","0.64 [0.25, 1.63]",0.64,0.25,1.63,0.95,{"$f":"IF(C18=\"\",\"\",LN(C18))","v":-0.44628710262841947},{"$f":"IF(OR(E18=\"\",D18=\"\",F18=\"\"),\"\", (LN(E18)-LN(D18))/(2*-NORMSINV((1-F18)/2)))","v":0.47829306832353347}]
["Gastric cancer (HIPEC + CRS vs systemic chemotherapy)","0.40 [0.30, 0.52]",0.4,0.3,0.52,0.95,{"$f":"IF(C19=\"\",\"\",LN(C19))","v":-0.916290731874155},{"$f":"IF(OR(E19=\"\",D19=\"\",F19=\"\"),\"\", (LN(E19)-LN(D19))/(2*-NORMSINV((1-F19)/2)))","v":0.14032052151416241}]
["Ovarian cancer (HIPEC + CRS vs CRS)","0.73 [0.57, 0.93]",0.73,0.56999999999999995,0.93,0.95,{"$f":"IF(C20=\"\",\"\",LN(C20))","v":-0.31471074483970024},{"$f":"IF(OR(E20=\"\",D20=\"\",F20=\"\"),\"\", (LN(E20)-LN(D20))/(2*-NORMSINV((1-F20)/2)))","v":0.12488704618559321}]
[]
["Costs","Regimen","HIPEC","CRS costs (uncomplicated)","CRS costs (complicated)","Systemic chemptherapy","Comments"]
["Colorectal cancer (HIPEC + CRS vs CRS)",null,{"$f":"CRC_HIPEC_CRS!J38","v":5705.1289998485736},{"$f":"CRC_HIPEC_CRS!J40","v":6199},{"$f":"CRC_HIPEC_CRS!J41","v":10568.456953642384},null,"1. See the individual sheets for breakdown of costs"]
["Colorectal cancer (HIPEC + CRS vs systemic chemotherapy)",null,{"$f":"CRC_HIPEC_Chem!J38","v":11254.534999848573},{"$f":"CRC_HIPEC_Chem!J40","v":6199},{"$f":"CRC_HIPEC_Chem!J41","v":10568.456953642384},{"$f":"CRC_HIPEC_Chem!J46","v":2503.8000000000002},"2. Variability: 30% of estimated average costs"]
["Gastric cancer (HIPEC + CRS vs CRS)",null,{"$f":"Gastric_HIPEC_CRS!J38","v":3259.0869998485741},{"$f":"Gastric_HIPEC_CRS!J40","v":6199},{"$f":"Gastric_HIPEC_CRS!J41","v":10568.456953642384},{"$f":"Gastric_HIPEC_CRS!J56","v":6829.12896}]
["Gastric cancer (HIPEC + CRS vs systemic chemotherapy)",null,{"$f":"Gastric_HIPEC_Chem!J38","v":9504.7589998485746},{"$f":"Gastric_HIPEC_Chem!J40","v":6199},{"$f":"Gastric_HIPEC_Chem!J41","v":10568.456953642384},{"$f":"Gastric_HIPEC_Chem!J49","v":12216.96}]
["Ovarian cancer (HIPEC + CRS vs CRS)",null,{"$f":"Ovarian_HIPEC_CRS!J38","v":3521.3649998485744},{"$f":"Ovarian_HIPEC_CRS!J40","v":6199},{"$f":"Ovarian_HIPEC_CRS!J41","v":10568.456953642384},{"$f":"Ovarian_HIPEC_CRS!J46","v":1768.2}]
[]
["Median Age"]
["Colorectal cancer (HIPEC + CRS vs CRS)",60,"Quenet et al"]
["Colorectal cancer (HIPEC + CRS vs systemic chemotherapy)",54,"Verwaal et al"]
["Gastric cancer (HIPEC + CRS vs CRS)",50,"Yang et al"]
["Gastric cancer (HIPEC + CRS vs systemic chemotherapy)",48,"Rudloff et al"]
["Ovarian cancer (HIPEC + CRS vs CRS)",61,"van Driel et al, Antonia et al, Lim et al (61,62,53 respectively)"]

{"sheet":"UserInput","index":7,"n_rows":8,"n_cols":2,"rows_kept":8,"cut":false,"hidden":false,"merged":[]}
["Base case"]
["Gender","Female"]
["Assumption","Same rate as medium-term death rate"]
["Type of cancer","Ovarian cancer"]
["Intervention (Fixed)","HIPEC + CRS + Systemic chemotherapy"]
["Control (Applicable only for colorectal and gastric cancers)","CRS+Chemotherapy"]
["Operating time costs","NHS costs"]
["Number of procedures per year",70]

{"sheet":"Input","index":8,"n_rows":95,"n_cols":12,"rows_kept":95,"cut":false,"hidden":false,"merged":[]}
["Uncertainty","1st Order","Costs (intervention)","B15"]
["Number of variables (automatically completed)",{"$f":"COUNTA(K:K)-4","v":16},"QALY (intervention)","B14"]
["Intervention","HIPEC + CRS + Chemotherapy","Costs (control)","B32"]
["Control","CRS + Chemotherapy","QALY (conrol)","B33"]
["Enter the mean and standard deviation in columns c & d for gamma distribution and continuous distribution, limits for uniform distribution in columns e and f, number with event and number without event for beta distribution in columns c & d and lower and upper limit in columns e and f\nComplete the variable name column only if you use the variable"]
["Parameters","Type of distribution","mean (gamma or continuous or uniform), number with event (dichotomous)","standard deviation (gamma or continuous), number without event (dichotomous)","Lower limit","Upper limit","Step","1st order","2nd order value","Live value","variable name","Source / Notes"]
["Basic parameters"]
["Time horizon (in years)",null,null,null,null,null,null,{"$f":"C8","v":0},{"$f":"C8","v":0},{"$f":"C8","v":0},"TimeHorizon","Life-time horizon based on National life tables"]
["Discount rate",null,3.5000000000000003E-2,null,null,null,null,{"$f":"C9","v":3.5000000000000003E-2},{"$f":"C9","v":3.5000000000000003E-2},{"$f":"C9","v":3.5000000000000003E-2},"DiscountRate"]
["Number patients simulated",null,10000,null,null,null,null,{"$f":"C10","v":10000},{"$f":"C10","v":10000},{"$f":"C10","v":10000},"CohortSize"]
["Variables"]
["Complications (HIPEC + CRS)","Beta",{"$f":"IF(OFFSET(SourceData!L2,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L2,0,SourceData!$I$4))","v":42},{"$f":"IF(OFFSET(SourceData!M2,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M2,0,SourceData!$I$4))","v":115},{"$f":"IF(OFFSET(SourceData!N2,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N2,0,SourceData!$I$4))","v":0},{"$f":"IF(OFFSET(SourceData!O2,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O2,0,SourceData!$I$4))","v":0.5},0.05,{"$f":"IF(B12=\"Beta\", C12/(C12+D12), IF(B12=\"Uniform\",(E12+F12)/2,IF(B12=\"Gamma\",C12,IF(B12=\"Continuous\",C12,\"\"))))","v":0.26751592356687898},{"$f":"IF(B12=\"Beta\",BETAINV(RAND(),C12,D12,E12,F12),IF(B12=\"Uniform\",E12+RAND()*(F12-E12),IF(B12=\"Gamma\",GAMMAINV(RAND(),C12^2/D12^2,(D12^2)/C12),IF(B12=\"Continuous\",NORMINV(RAND(),C12,D12),\"\"))))","v":0.11694777269266733},{"$f":"IF(Uncertainty=\"1st Order\",H12,IF(ISERROR(I12),H12,I12))","v":0.26751592356687898},"p_Complications_HIPEC",{"$f":"IF(OFFSET(SourceData!P2,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P2,0,SourceData!$I$4))","v":"Systematic review (from: van Driel et al and Antonia et al)"}]
["Short-term mortality (HIPEC + CRS)","Beta",{"$f":"IF(OFFSET(SourceData!L3,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L3,0,SourceData!$I$4))","v":1},{"$f":"IF(OFFSET(SourceData!M3,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M3,0,SourceData!$I$4))","v":156},{"$f":"IF(OFFSET(SourceData!N3,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N3,0,SourceData!$I$4))","v":0},{"$f":"IF(OFFSET(SourceData!O3,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O3,0,SourceData!$I$4))","v":0.1},0.05,6.369426751592357E-3,2.667795971883267E-4,6.369426751592357E-3,"p_Short_term_Mortality_HIPEC",{"$f":"IF(OFFSET(SourceData!P3,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P3,0,SourceData!$I$4))","v":"From: van Driel et al and Antonia et al"}]
["Survival ln (hazard ratio)","Continuous",{"$f":"IF(OFFSET(SourceData!L4,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L4,0,SourceData!$I$4))","v":-0.31471074483970024},{"$f":"IF(OFFSET(SourceData!M4,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M4,0,SourceData!$I$4))","v":0.12488704618559321},{"$f":"IF(OFFSET(SourceData!N4,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N4,0,SourceData!$I$4))","v":-2},{"$f":"IF(OFFSET(SourceData!O4,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O4,0,SourceData!$I$4))","v":2},0.05,-0.31471074483970024,-0.43825792098274519,-0.31471074483970024,"p_Ln_HazardRatio_HIPEC",{"$f":"IF(OFFSET(SourceData!P4,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P4,0,SourceData!$I$4))","v":"Systematic review (from: van Driel et al, Antonia et al, Lim et al)"}]
["Complications (Control)","Beta",{"$f":"IF(OFFSET(SourceData!L5,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L5,0,SourceData!$I$4))","v":40},{"$f":"IF(OFFSET(SourceData!M5,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M5,0,SourceData!$I$4))","v":119},{"$f":"IF(OFFSET(SourceData!N5,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N5,0,SourceData!$I$4))","v":0},{"$f":"IF(OFFSET(SourceData!O5,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O5,0,SourceData!$I$4))","v":0.5},0.05,{"$f":"IF(B15=\"Beta\", C15/(C15+D15), IF(B15=\"Uniform\",(E15+F15)/2,IF(B15=\"Gamma\",C15,IF(B15=\"Continuous\",C15,\"\"))))","v":0.25157232704402516},{"$f":"IF(B15=\"Beta\",BETAINV(RAND(),C15,D15,E15,F15),IF(B15=\"Uniform\",E15+RAND()*(F15-E15),IF(B15=\"Gamma\",GAMMAINV(RAND(),C15^2/D15^2,(D15^2)/C15),IF(B15=\"Continuous\",NORMINV(RAND(),C15,D15),\"\"))))","v":0.14030703320478133},0.25157232704402516,"p_Complications_Control",{"$f":"IF(OFFSET(SourceData!P5,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P5,0,SourceData!$I$4))","v":"Systematic review (from: van Driel et al and Antonia et al)"}]
["Short-term mortality (Control)","Beta",{"$f":"IF(OFFSET(SourceData!L6,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L6,0,SourceData!$I$4))","v":2},{"$f":"IF(OFFSET(SourceData!M6,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M6,0,SourceData!$I$4))","v":157},{"$f":"IF(OFFSET(SourceData!N6,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N6,0,SourceData!$I$4))","v":0},{"$f":"IF(OFFSET(SourceData!O6,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O6,0,SourceData!$I$4))","v":0.1},0.05,1.2578616352201259E-2,1.7321059951641684E-3,1.2578616352201259E-2,"p_Short_term_Mortality_Control",{"$f":"IF(OFFSET(SourceData!P6,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P6,0,SourceData!$I$4))","v":"From: van Driel et al and Antonia et al"}]
["5-year mortality (Control)","Beta",{"$f":"IF(OFFSET(SourceData!L7,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L7,0,SourceData!$I$4))","v":123},{"$f":"IF(OFFSET(SourceData!M7,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M7,0,SourceData!$I$4))","v":92},{"$f":"IF(OFFSET(SourceData!N7,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N7,0,SourceData!$I$4))","v":0},{"$f":"IF(OFFSET(SourceData!O7,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O7,0,SourceData!$I$4))","v":1},0.05,0.5720930232558139,0.56504733130593943,0.5720930232558139,"p_MediumMortality_Control",{"$f":"IF(OFFSET(SourceData!P7,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P7,0,SourceData!$I$4))","v":"Systematic review (from: van Driel et al and Lim et al). The number of deaths was reported only in these two trials, but the hazard ratios were reported in the three trials"}]
["Cost (HIPEC + CRS) Complicated","Uniform",{"$f":"IF(OFFSET(SourceData!L8,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L8,0,SourceData!$I$4))","v":15858.021953490959},{"$f":"IF(OFFSET(SourceData!M8,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M8,0,SourceData!$I$4))","v":""},{"$f":"IF(OFFSET(SourceData!N8,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N8,0,SourceData!$I$4))","v":11100.61536744367},{"$f":"IF(OFFSET(SourceData!O8,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O8,0,SourceData!$I$4))","v":20615.428539538247},500,{"$f":"IF(B18=\"Beta\", C18/(C18+D18), IF(B18=\"Uniform\",(E18+F18)/2,IF(B18=\"Gamma\",C18,IF(B18=\"Continuous\",C18,\"\"))))","v":15858.021953490959},12636.347647446173,15858.021953490959,"Costs_Complicated_HIPEC",{"$f":"IF(OFFSET(SourceData!P8,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P8,0,SourceData!$I$4))","v":"See Sheet 'Ovarian_HIPEC_CRS'"}]
["Cost (HIPEC + CRS) Uncomplicated","Uniform",{"$f":"IF(OFFSET(SourceData!L9,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L9,0,SourceData!$I$4))","v":11488.564999848575},{"$f":"IF(OFFSET(SourceData!M9,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M9,0,SourceData!$I$4))","v":""},{"$f":"IF(OFFSET(SourceData!N9,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N9,0,SourceData!$I$4))","v":8041.995499894002},{"$f":"IF(OFFSET(SourceData!O9,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O9,0,SourceData!$I$4))","v":14935.134499803147},500,{"$f":"IF(B19=\"Beta\", C19/(C19+D19), IF(B19=\"Uniform\",(E19+F19)/2,IF(B19=\"Gamma\",C19,IF(B19=\"Continuous\",C19,\"\"))))","v":11488.564999848575},10824.562024922068,11488.564999848575,"Costs_Uncomplicated_HIPEC",{"$f":"IF(OFFSET(SourceData!P9,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P9,0,SourceData!$I$4))","v":"See Sheet 'Ovarian_HIPEC_CRS'"}]
["Cost (Control) Complicated","Uniform",{"$f":"IF(OFFSET(SourceData!L10,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L10,0,SourceData!$I$4))","v":12336.656953642385},{"$f":"IF(OFFSET(SourceData!M10,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M10,0,SourceData!$I$4))","v":""},{"$f":"IF(OFFSET(SourceData!N10,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N10,0,SourceData!$I$4))","v":8635.659867549668},{"$f":"IF(OFFSET(SourceData!O10,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O10,0,SourceData!$I$4))","v":16037.654039735102},500,12336.656953642385,15547.29875891269,12336.656953642385,"Costs_Complicated_Control",{"$f":"IF(OFFSET(SourceData!P10,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P10,0,SourceData!$I$4))","v":"See Sheet 'Ovarian_HIPEC_CRS'"}]
["Cost (Control) Uncomplicated","Uniform",{"$f":"IF(OFFSET(SourceData!L11,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L11,0,SourceData!$I$4))","v":7967.2},{"$f":"IF(OFFSET(SourceData!M11,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M11,0,SourceData!$I$4))","v":""},{"$f":"IF(OFFSET(SourceData!N11,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N11,0,SourceData!$I$4))","v":5577.04},{"$f":"IF(OFFSET(SourceData!O11,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O11,0,SourceData!$I$4))","v":10357.36},500,{"$f":"IF(B21=\"Beta\", C21/(C21+D21), IF(B21=\"Uniform\",(E21+F21)/2,IF(B21=\"Gamma\",C21,IF(B21=\"Continuous\",C21,\"\"))))","v":7967.2000000000007},7229.8456355953549,7967.2000000000007,"Costs_Uncomplicated_Control",{"$f":"IF(OFFSET(SourceData!P11,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P11,0,SourceData!$I$4))","v":"See Sheet 'Ovarian_HIPEC_CRS'"}]
["QoL (complicated HIPEC + CRS) (Short-term)","Beta",{"$f":"IF(OFFSET(SourceData!L12,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L12,0,SourceData!$I$4))","v":0.50129999999999997},{"$f":"IF(OFFSET(SourceData!M12,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M12,0,SourceData!$I$4))","v":0.49870000000000003},{"$f":"IF(OFFSET(SourceData!N12,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N12,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O12,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O12,0,SourceData!$I$4))","v":0.9},0.05,0.50129999999999997,0.23574084187440705,0.50129999999999997,"QoL_Complicated_HIPEC",{"$f":"IF(OFFSET(SourceData!P12,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P12,0,SourceData!$I$4))","v":"Hypothetical 0.1 less in complicated"}]
["QoL (uncomplicated HIPEC + CRS) (Short-term)","Beta",{"$f":"IF(OFFSET(SourceData!L13,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L13,0,SourceData!$I$4))","v":0.60129999999999995},{"$f":"IF(OFFSET(SourceData!M13,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M13,0,SourceData!$I$4))","v":0.39870000000000005},{"$f":"IF(OFFSET(SourceData!N13,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N13,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O13,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O13,0,SourceData!$I$4))","v":0.9},0.05,0.60129999999999995,0.88039708689448848,0.60129999999999995,"QoL_Uncomplicated_HIPEC",{"$f":"IF(OFFSET(SourceData!P13,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P13,0,SourceData!$I$4))","v":"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (3 months)"}]
["QoL (Complicated CRS) (Short-term)","Beta",{"$f":"IF(OFFSET(SourceData!L14,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L14,0,SourceData!$I$4))","v":0.50461200000000006},{"$f":"IF(OFFSET(SourceData!M14,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M14,0,SourceData!$I$4))","v":0.49538799999999994},{"$f":"IF(OFFSET(SourceData!N14,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N14,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O14,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O14,0,SourceData!$I$4))","v":0.9},0.05,0.50461200000000006,0.21811981233978428,0.50461200000000006,"QoL_Complicated_Control",{"$f":"IF(OFFSET(SourceData!P14,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P14,0,SourceData!$I$4))","v":"Hypothetical 0.1 less in complicated"}]
["QoL (Uncomplicated CRS) (Short-term)","Beta",{"$f":"IF(OFFSET(SourceData!L15,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L15,0,SourceData!$I$4))","v":0.60461200000000004},{"$f":"IF(OFFSET(SourceData!M15,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M15,0,SourceData!$I$4))","v":0.39538799999999996},{"$f":"IF(OFFSET(SourceData!N15,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N15,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O15,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O15,0,SourceData!$I$4))","v":0.9},0.05,0.60461200000000004,0.56898430611896689,0.60461200000000004,"QoL_Uncomplicated_Control",{"$f":"IF(OFFSET(SourceData!P15,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P15,0,SourceData!$I$4))","v":"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (3 months)"}]
["QoL (Long-term) HIPEC","Beta",{"$f":"IF(OFFSET(SourceData!L16,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L16,0,SourceData!$I$4))","v":0.60599999999999998},{"$f":"IF(OFFSET(SourceData!M16,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M16,0,SourceData!$I$4))","v":0.39400000000000002},{"$f":"IF(OFFSET(SourceData!N16,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N16,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O16,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O16,0,SourceData!$I$4))","v":0.9},0.05,{"$f":"IF(B26=\"Beta\", C26/(C26+D26), IF(B26=\"Uniform\",(E26+F26)/2,IF(B26=\"Gamma\",C26,IF(B26=\"Continuous\",C26,\"\"))))","v":0.60599999999999998},0.82211310640253277,0.60599999999999998,"QoL_Long_HIPEC",{"$f":"IF(OFFSET(SourceData!P16,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P16,0,SourceData!$I$4))","v":"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (12 months)"}]
["QoL (Long-term) Control","Beta",{"$f":"IF(OFFSET(SourceData!L17,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!L17,0,SourceData!$I$4))","v":0.60599999999999998},{"$f":"IF(OFFSET(SourceData!M17,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!M17,0,SourceData!$I$4))","v":0.39400000000000002},{"$f":"IF(OFFSET(SourceData!N17,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!N17,0,SourceData!$I$4))","v":0.1},{"$f":"IF(OFFSET(SourceData!O17,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!O17,0,SourceData!$I$4))","v":0.9},0.05,0.60599999999999998,0.84376771884324986,0.60599999999999998,"QoL_Long_Control",{"$f":"IF(OFFSET(SourceData!P17,0,SourceData!$I$4)=\"\",\"\",OFFSET(SourceData!P17,0,SourceData!$I$4))","v":"Antonia et al, converted using Kim SH, Jo MW, Kim HJ, Ahn JH. Mapping EORTC QLQ-C30 onto EQ-5D for the assessment of cancer patients. Health Qual Life Outcomes. 2012 Dec 17;10:151. doi: 10.1186/1477-7525-10-151. PMID: 23244763; PMCID: PMC3542092. (12 months)"}]
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{"sheet":"Stability","index":9,"n_rows":33,"n_cols":18,"rows_kept":33,"cut":false,"hidden":true,"merged":[]}
["Different conditions",null,null,null,null,null,null,"Runs","WTP: 20000","WTP: 30000","WTP: 20000","WTP: 30000","WTP: 20000","WTP: 30000","WTP: 20000","WTP: 30000","WTP: 20000","WTP: 30000"]
[null,"Male","Male","Male","Male","Female",null,null,"Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)","Incremental NMB (Point estimate)"]
[null,"Same rate as medium-term death rate","Same rate as medium-term death rate","Same rate as medium-term death rate","Same rate as medium-term death rate","Same rate as medium-term death rate",null,1,-2594662,-927336,104588977,162563866,8671402,14676274,63524459,100189895,43740841,67393389]
[null,"Colorectal cancer","Colorectal cancer","Gastric cancer","Gastric cancer","Ovarian cancer",null,2,-1895069,124870,104491274,162427829,8623877,14609159,63183580,99723480,42853265,66059926]
[null,"HIPEC + CRS + Systemic chemotherapy","HIPEC + CRS + Systemic chemotherapy","HIPEC + CRS + Systemic chemotherapy","HIPEC + CRS + Systemic chemotherapy","HIPEC + CRS + Systemic chemotherapy",null,3,-2108338,-196556,105120604,163367701,8585394,14547987,63362399,99931742,43485294,67000168]
[null,"CRS+Chemotherapy","Chemotherapy without CRS","CRS+Chemotherapy","Chemotherapy without CRS","CRS+Chemotherapy",null,4,-2018111,-61452,103935895,161589837,8047463,13730906,65095759,102604243,44157980,67992754]
[null,"NHS costs","NHS costs","NHS costs","NHS costs","NHS costs",null,5,-2488646,-770443,104906203,163049772,8564863,14508234,64049489,100978904,42985734,66263993]
[null,70,70,70,70,70,null,6,-2382053,-607300,105528468,164001199,8360169,14195502,64834551,102139111,43312132,66756338]
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["Name of file","HIPEC_CRC_CRS","HIPEC_CRC_Chemo","HIPEC_Gastric_CRS","HIPEC_Gastric_Chemo","HIPEC_Ovarian_CRS",null,8,-2680719,-1053337,104386829,162281972,8420881,14296141,64709498,101972296,44114742,67925835]
["Analysis completed",30,30,30,30,30,null,9,-2526849,-826995,103759734,161335699,9059035,15253432,63571534,100287597,43735343,67383969]
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["Iterations",90000,10000,90000,15000,10000,null,20,-2548047,-850228,104141435,161908700,7984885,13632396,65163653,102706899,43871691,67574715]
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{"sheet":"QALYCalculation","index":10,"n_rows":109,"n_cols":15,"rows_kept":109,"cut":false,"hidden":false,"merged":[]}
["Basecase",{"$f":"OFFSET(SourceData!$B$29,SourceData!$I$2,0)","v":61},"Row number",{"$f":"MATCH(B1,NationalLifeTables!A:A,0)","v":68},"Life-time discounted QALY (Control)",{"$f":"SUM(D10:D109)","v":4.0039022790284911},"HR",{"$f":"EXP(p_Ln_HazardRatio_HIPEC_live)","v":0.73},null,null,null,null,null,null,"Formula for calculation of percent alive"]
["Gender",{"$f":"IF(UserInput!B4=\"Ovarian cancer\",\"Female\",IF(UserInput!B2=\"\",\"Male\",UserInput!B2))","v":"Female"},null,null,"Life-time discounted QALY (HIPEC)",{"$f":"SUM(F10:F109)","v":6.5128095989387162},null,null,null,null,null,null,null,null,"1. If the period is equal to or below the medium term, then the annualised rate observed in the studies is used."]
["Assumption",{"$f":"UserInput!B3","v":"Same rate as medium-term death rate"},null,null,null,null,null,null,null,null,null,null,null,null,"2. If the period is above the medium term, if the assumption is that mortality rate beyond medium term is the same as the original death rate, then the annualised rate observed in the study is used. Otherwise, the proportion survived is used from National Life tables for that age group."]
["Medium term",{"$f":"OFFSET(SourceData!$B$7,SourceData!$I$2,0)","v":4}]
["Annualised rate of death until medium term (control group)",{"$f":"1-p_MediumMortality_Control_live^(1/B4)","v":0.13030562155077352}]
[]
[]
[null,"Control group",null,null,"HIPEC",null,null,null,null,null,"Sample calculations (for explanation)",null,null,null,"Formula for calculation of proportion survived in intervention group"]
["Age","Percent alive (undiscounted) CRS","Average proportion alive","Discounted QALY","Average percentage alive","Discounted QALY",null,null,null,null,"QoL","Undiscounted QALY","Discounted QALY",null,"1. ln HR has to be converted to exp"]
[{"$f":"B1","v":61},1,{"$f":"AVERAGE(B10,B9)","v":1},{"$f":"C10*QoL_Long_Control_live*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.60599999999999998},{"$f":"MAX(0,MIN(100%,E9,(1-(1-C10)*EXP(p_Ln_HazardRatio_HIPEC_live))))","v":1},{"$f":"E10*QoL_Long_HIPEC_live*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.60599999999999998},null,null,null,null,{"$f":"QoL_Long_Control_live","v":0.60599999999999998},{"$f":"C10*K10","v":0.60599999999999998},{"$f":"L10*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.60599999999999998},null,"2. But this is hazard of death (and not survival - so percent alive should be convered to percent dead)"]
[{"$f":"IF(A10<100,A10+1,\"\")","v":62},{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B10*(1-B$5),B10*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.86969437844922648},{"$f":"AVERAGE(B11,B10)","v":0.9348471892246133},0.54668928778666159,0.95243844813396772,0.55697648008426293,null,null,null,null,0.60599999999999998,0.56651739667011569,0.54668928778666159,null,"3. Percent dead should then be convered to percent alive, noting that it cannot be more than 100% or the previous survival or cannot be less than 0%"]
[{"$f":"IF(A11<100,A11+1,\"\")","v":63},{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B11*(1-B$5),B11*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.75636831190618636},0.81303134517770648,0.45881175933434448,0.86351288197972575,0.48729961881407141,null,null,null,null,0.60599999999999998,0.49269699517769011,0.45881175933434448]
[64,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B12*(1-B$5),B12*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.65780926890194147},0.70708879040406392,0.38506009758439697,0.78617481699496672,0.42812805952910982,null,null,null,null,0.60599999999999998,0.42849580698486273,0.38506009758439697]
[65,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B13*(1-B$5),B13*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.57209302325581413},0.6149511460788778,0.32316364115606155,0.71891433663758075,0.3777974497461874,null,null,null,null,0.60599999999999998,0.37266039452379995,0.32316364115606155]
[66,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B14*(1-B$5),B14*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.49754608627560415},{"$f":"AVERAGE(B15,B14)","v":0.53481955476570908},{"$f":"C15*QoL_Long_Control_live*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.27121672596146845},{"$f":"MAX(0,MIN(100%,E14,(1-(1-C15)*EXP(p_Ln_HazardRatio_HIPEC_live))))","v":0.66041827497896766},{"$f":"E15*QoL_Long_HIPEC_live*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.33491012194455527},null,null,null,null,0.60599999999999998,{"$f":"C15*K15","v":0.3241006501880197},{"$f":"L15*(1-DiscountRate_live)^(ROW()-ROW($D$10))","v":0.27121672596146845}]
[67,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B15*(1-B$5),B15*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.43271303425330676},0.46512956026445545,0.22762001374324023,0.60954457899305248,0.29829225510550472,null,null,null,null,0.60599999999999998,0.28186851352025999,0.22762001374324023]
[68,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B16*(1-B$5),B16*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.37632809337180845},0.40452056381255763,0.19103125175190558,0.56530001158316701,0.26695792127427753,null,null,null,null,0.60599999999999998,0.24513946167040992,0.19103125175190558]
[69,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B17*(1-B$5),B17*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.32729042725797741},0.3518092603148929,0.16032394755526491,0.52682076002987177,0.2400789104483913,null,null,null,null,0.60599999999999998,0.2131964117508251,0.16032394755526491]
[70,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B18*(1-B$5),B18*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.28464264470650846},0.30596653598224294,0.13455268666241643,0.49335557126703744,0.21695940499095528,null,null,null,null,0.60599999999999998,0.18541572080523921,0.13455268666241643]
[71,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B19*(1-B$5),B19*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.24755210796817087},0.26609737633733965,0.11292402516369975,0.46425108472625798,0.19701472406643339,null,null,null,null,0.60599999999999998,0.16125501006042783,0.11292402516369975]
[72,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B20*(1-B$5),B20*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.21529467667317417},0.23142339232067252,9.4772061231043134E-2,0.43893907639409102,0.17975348389620144,null,null,null,null,0.60599999999999998,0.14024257574632754,9.4772061231043134E-2]
[73,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B21*(1-B$5),B21*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.18724057001270339},0.2012676233429388,7.9537933375650155E-2,0.41692536504034539,0.16476262478985065,null,null,null,null,0.60599999999999998,0.1219681797458209,7.9537933375650155E-2]
[74,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B22*(1-B$5),B22*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.16284207115767696},0.17504132058519017,6.6752614256712528E-2,0.39778016402718885,0.15169484416312926,null,null,null,null,0.60599999999999998,0.10607504027462525,6.6752614256712528E-2]
[75,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B23*(1-B$5),B23*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.14162283386086058},0.15223245250926876,5.602247029804773E-2,0.38112969033176625,0.14025804882185344,null,null,null,null,0.60599999999999998,9.2252866220616861E-2,5.602247029804773E-2]
[76,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B24*(1-B$5),B24*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.1231685824688392},0.13239570816484988,4.7017142523074089E-2,0.36664886696034049,0.13020650195347294,null,null,null,null,0.60599999999999998,8.0231799147899033E-2,4.7017142523074089E-2]
[77,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B25*(1-B$5),B25*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":0.1071190237747094},0.1151438031217743,3.9459375484056397E-2,0.35405497627889526,0.12133339243808298,null,null,null,null,0.60599999999999998,6.9777144691795231E-2,3.9459375484056397E-2]
[78,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B26*(1-B$5),B26*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":9.3160812801833803E-2},0.1001399182882716,3.3116481139355024E-2,0.34310214035043829,0.11346459787473573,null,null,null,null,0.60599999999999998,6.0684790482692583E-2,3.3116481139355024E-2]
[79,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B27*(1-B$5),B27*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":8.1021435185515592E-2},8.7091123993674691E-2,2.7793174869084811E-2,0.33357652051538256,0.10645344946493325,null,null,null,null,0.60599999999999998,5.2777221140166863E-2,2.7793174869084811E-2]
[80,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B28*(1-B$5),B28*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":7.0463886714731278E-2},7.5742660950123442E-2,2.33255630648979E-2,0.32529214249359018,0.10017633773450926,null,null,null,null,0.60599999999999998,4.5900052535774803E-2,2.33255630648979E-2]
[81,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B29*(1-B$5),B29*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":6.1282046159484925E-2},6.5872966437108105E-2,1.9576097184194952E-2,0.31808726549908894,9.4529023957196409E-2,null,null,null,null,0.60599999999999998,3.9919017660887512E-2,1.9576097184194952E-2]
[82,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B30*(1-B$5),B30*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":5.3296651044770049E-2},5.7289348602127491E-2,1.642933891451263E-2,0.31182122447955307,8.9423543864882604E-2,null,null,null,null,0.60599999999999998,3.4717345252889262E-2,1.642933891451263E-2]
[83,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B31*(1-B$5),B31*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":4.6351797803806605E-2},4.9824224424288327E-2,1.3788406066243141E-2,0.30637168382973057,8.478560845964081E-2,null,null,null,null,0.60599999999999998,3.0193480001118725E-2,1.3788406066243141E-2]
[84,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B32*(1-B$5),B32*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":4.0311897980985806E-2},4.3331847892396205E-2,1.1571989770061332E-2,0.30163224896144925,8.0552422042333149E-2,null,null,null,null,0.60599999999999998,2.6259099822792099E-2,1.1571989770061332E-2]
[85,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B33*(1-B$5),B33*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":3.5059031058682077E-2},3.7685464519833942E-2,9.7118511447269965E-3,0.2975103890994788,7.6670850412982494E-2,null,null,null,null,0.60599999999999998,2.283739149901937E-2,9.7118511447269965E-3]
[86,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B34*(1-B$5),B34*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":3.0490642225612635E-2},3.2774836642147358E-2,8.1507203628330867E-3,0.29392563074876754,7.3095882974493306E-2,null,null,null,null,0.60599999999999998,1.9861551005141299E-2,8.1507203628330867E-3]
[87,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B35*(1-B$5),B35*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":2.6517540138921918E-2},2.8504091182267276E-2,6.8405334310722094E-3,0.29080798656305518,6.9789341515471004E-2,null,null,null,null,0.60599999999999998,1.727347925645397E-2,6.8405334310722094E-3]
[88,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B36*(1-B$5),B36*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":2.3062155589122113E-2},2.4789847864022017E-2,5.7409523991265865E-3,0.28809658894073609,6.671879603827309E-2,null,null,null,null,0.60599999999999998,1.5022647805597342E-2,5.7409523991265865E-3]
[89,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B37*(1-B$5),B37*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":2.005702707078091E-2},2.1559591329951514E-2,4.818123437468718E-3,0.28573850167086468,6.3856654368720997E-2,null,null,null,null,0.60599999999999998,1.3065112345950617E-2,4.818123437468718E-3]
[90,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B38*(1-B$5),B38*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":1.7443483691862112E-2},1.8750255381321509E-2,4.0436345478525705E-3,0.28368768642836473,6.117939763022328E-2,null,null,null,null,0.60599999999999998,1.1362654761080834E-2,4.0436345478525705E-3]
[91,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B39*(1-B$5),B39*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":1.5170499707383238E-2},1.6306991699622676E-2,3.3936408165534948E-3,0.28190410394072463,5.8666938152014778E-2,null,null,null,null,0.60599999999999998,9.8820369699713414E-3,3.3936408165534948E-3]
[92,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B40*(1-B$5),B40*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":1.3193698313776836E-2},1.4182099010580037E-2,2.8481302787102813E-3,0.2803529322777234,5.6302080146931631E-2,null,null,null,null,0.60599999999999998,8.594352000411502E-3,2.8481302787102813E-3]
[93,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B41*(1-B$5),B41*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":1.1474485254446753E-2},1.2334091784111795E-2,2.3903077912483732E-3,0.27900388700240164,5.4070066654562904E-2,null,null,null,null,0.60599999999999998,7.474459621171747E-3,2.3903077912483732E-3]
[94,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B42*(1-B$5),B42*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":9.9792953213908835E-3},1.0726890287918818E-2,2.0060779451036739E-3,0.27783062991018082,5.1958198898033971E-2,null,null,null,null,0.60599999999999998,6.5004955144788035E-3,2.0060779451036739E-3]
[95,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B43*(1-B$5),B43*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":8.6789370418983176E-3},9.3291161816446005E-3,1.6836110966820736E-3,0.27681025481260058,4.99555164287524E-2,null,null,null,null,0.60599999999999998,5.6534444060766277E-3,1.6836110966820736E-3]
[96,{"$f":"IF(OR(ROW()-ROW($B$10)<=B$4,$B$3=\"Same rate as medium-term death rate\"),B44*(1-B$5),B44*(1-OFFSET(IF(B$2=\"Male\",NationalLifeTables!$C$1,NationalLifeTables!$J$1),$D$1-1+ROW()-ROW($B$10),0)))","v":7.5480227562537252E-3},8.1134798990760218E-3,1.4129791575593666E-3,0.27592284032632552,4.8052528301706719E-2,null,null,null,null,0.60599999999999998,4.9167688188400688E-3,1.4129791575593666E-3]
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{"sheet":"NationalLifeTables","index":11,"n_rows":108,"n_cols":15,"rows_kept":108,"cut":false,"hidden":false,"merged":[]}
["National Life Tables, United Kingdom, period expectation of life, based on data for the years 2018-2020",null,null,null,null,null,null,null,null,null,null,null,null,null,"National Life Tables"]
["This worksheet contains two tables, presented horizontally with one blank column in between the tables.",null,null,null,null,null,null,null,null,null,null,null,null,null,"Notation"]
["This worksheet uses notation in the column headers, please see the notation worksheet for explanations.",null,null,null,null,null,null,null,null,null,null,null,null,null,"mx"]
[{"$f":"HYPERLINK(\"#'Contents'!A1\", \"Back to contents\")","v":"Back to contents"},null,null,null,null,null,null,null,null,null,null,null,null,null,"is the central rate of mortality, defined as the number of deaths at age x last birthday in the three year period to which the National Life Table "]
["National life tables, Males",null,null,null,null,null,null,"National life tables, Females",null,null,null,null,null,null,"relates divided by the average population at that age over the same period."]
["age","mx","qx","lx","dx","ex","","age","mx","qx","lx","dx","ex",null,"qx"]
[0,4.2329999999999998E-3,4.2240000000000003E-3,100000,422.4,79.040000000000006,"",0,3.509E-3,3.503E-3,100000,350.3,82.86,null,"is the mortality rate between age x and (x +1), that is the probability that a person aged x exact will die before reaching age (x +1)."]
[1,2.2900000000000001E-4,2.2900000000000001E-4,99577.600000000006,22.8,78.37,"",1,2.14E-4,2.14E-4,99649.7,21.4,82.15,null,"lx"]
[2,1.27E-4,1.27E-4,99554.8,12.6,77.39,null,2,1.1400000000000001E-4,1.1400000000000001E-4,99628.4,11.4,81.17,null,"is the number of survivors to exact age x of 100,000 live births of the same sex who are assumed to be subject throughout their lives to the "]
[3,1.02E-4,1.02E-4,99542.2,10.199999999999999,76.400000000000006,"",3,9.5000000000000005E-5,9.5000000000000005E-5,99617,9.4,80.180000000000007,null,"mortality rates experienced in the three year period to which the National Life Table relates."]
[4,8.6000000000000003E-5,8.6000000000000003E-5,99532,8.5,75.41,"",4,6.3999999999999997E-5,6.3999999999999997E-5,99607.5,6.4,79.180000000000007,null,"dx"]
[5,7.3999999999999996E-5,7.3999999999999996E-5,99523.5,7.4,74.42,"",5,7.3999999999999996E-5,7.3999999999999996E-5,99601.2,7.4,78.19,null,"is the number dying between exact age x and (x +1) described similarly to lx, that is dx=lx-lx+1."]
[6,8.5000000000000006E-5,8.5000000000000006E-5,99516.1,8.4,73.42,"",6,7.1000000000000005E-5,7.1000000000000005E-5,99593.8,7.1,77.19,null,"ex"]
[7,6.7000000000000002E-5,6.7000000000000002E-5,99507.6,6.6,72.430000000000007,"",7,5.5000000000000002E-5,5.5000000000000002E-5,99586.7,5.4,76.2,null,"is the average period expectation of life at exact age x, that is the average number of years that those aged x exact will live thereafter"]
[8,6.8999999999999997E-5,6.8999999999999997E-5,99501,6.9,71.430000000000007,"",8,5.8E-5,5.8E-5,99581.3,5.8,75.2,null,"based on the mortality rates experienced in the three year period to which the National Life Table relates."]
[9,6.0000000000000002E-5,6.0000000000000002E-5,99494.1,6,70.44,"",9,5.1E-5,5.1E-5,99575.5,5.0999999999999996,74.209999999999994]
[10,7.7999999999999999E-5,7.7999999999999999E-5,99488.2,7.8,69.44,"",10,6.6000000000000005E-5,6.6000000000000005E-5,99570.4,6.6,73.209999999999994]
[11,7.7000000000000001E-5,7.7000000000000001E-5,99480.4,7.7,68.45,"",11,5.5000000000000002E-5,5.5000000000000002E-5,99563.9,5.5,72.22]
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[78,4.6233000000000003E-2,4.5187999999999999E-2,63648,2876.1,9.44,"",78,3.1920999999999998E-2,3.1419999999999997E-2,74334.8,2335.6,10.95]
[79,5.1554999999999997E-2,5.0258999999999998E-2,60771.9,3054.3,8.8699999999999992,"",79,3.6361999999999998E-2,3.5713000000000002E-2,71999.3,2571.3000000000002,10.29]
[80,5.7764000000000003E-2,5.6142999999999998E-2,57717.599999999999,3240.4,8.31,"",80,4.0411999999999997E-2,3.9611E-2,69428,2750.1,9.66]
[81,6.4015000000000002E-2,6.2030000000000002E-2,54477.1,3379.2,7.77,"",81,4.6168000000000001E-2,4.5127E-2,66677.899999999994,3009,9.0299999999999994]
[82,7.1677000000000005E-2,6.9196999999999995E-2,51097.9,3535.8,7.26,"",82,5.1489E-2,5.0196999999999999E-2,63668.9,3196,8.44]
[83,8.0609E-2,7.7485999999999999E-2,47562.1,3685.4,6.76,"",83,5.8835999999999999E-2,5.7154999999999997E-2,60472.9,3456.3,7.86]
[84,9.128E-2,8.7295999999999999E-2,43876.7,3830.2,6.28,"",84,6.7335000000000006E-2,6.5142000000000005E-2,57016.6,3714.2,7.3]
[85,0.10247000000000001,9.7475999999999993E-2,40046.5,3903.6,5.84,"",85,7.6572000000000001E-2,7.3747999999999994E-2,53302.5,3931,6.78]
[86,0.11665,0.110221,36142.9,3983.7,5.41,"",86,8.8248999999999994E-2,8.4519999999999998E-2,49371.5,4172.8999999999996,6.28]
[87,0.13084200000000001,0.122808,32159.200000000001,3949.4,5.0199999999999996,"",87,0.10075000000000001,9.5918000000000003E-2,45198.6,4335.3999999999996,5.81]
[88,0.14782799999999999,0.137654,28209.8,3883.2,4.6500000000000004,"",88,0.113939,0.107798,40863.199999999997,4405,5.37]
[89,0.16744999999999999,0.15451300000000001,24326.6,3758.8,4.32,"",89,0.12948200000000001,0.12160899999999999,36458.300000000003,4433.6000000000004,4.96]
[90,0.17804300000000001,0.163489,20567.8,3362.6,4.0199999999999996,"",90,0.14645900000000001,0.136466,32024.6,4370.3,4.58]
[91,0.201824,0.18332499999999999,17205.2,3154.1,3.7,"",91,0.166188,0.15343799999999999,27654.400000000001,4243.2,4.22]
[92,0.22329599999999999,0.20086899999999999,14051.1,2822.4,3.42,"",92,0.18701899999999999,0.17102600000000001,23411.1,4003.9,3.9]
[93,0.25096099999999999,0.22298100000000001,11228.7,2503.8000000000002,3.16,"",93,0.20941699999999999,0.18956799999999999,19407.2,3679,3.6]
[94,0.27868999999999999,0.24460599999999999,8724.9,2134.1999999999998,2.92,"",94,0.23197999999999999,0.20787,15728.2,3269.4,3.32]
[95,0.31073800000000001,0.268951,6590.7,1772.6,2.7,"",95,0.26017699999999999,0.23022699999999999,12458.8,2868.4,3.06]
[96,0.33985700000000002,0.29049399999999997,4818.1000000000004,1399.6,2.5099999999999998,"",96,0.28986299999999998,0.25317099999999998,9590.5,2428,2.83]
[97,0.37254900000000002,0.31405,3418.5,1073.5999999999999,2.34,"",97,0.32279799999999997,0.27793899999999999,7162.4,1990.7,2.62]
[98,0.40313500000000002,0.335507,2344.9,786.7,2.1800000000000002,"",98,0.35245599999999999,0.299649,5171.7,1549.7,2.4300000000000002]
[99,0.453901,0.36994199999999999,1558.2,576.4,2.02,"",99,0.38082500000000002,0.31991000000000003,3622,1158.7,2.2599999999999998]
[100,0.48525400000000002,0.39050600000000002,981.7,383.4,1.91,"",100,0.42533399999999999,0.350742,2463.3000000000002,864,2.09]
[100,0.47583900000000001,0.38438600000000001,1119.3,430.2,2.02,"",0.41453000000000001,0.34336299999999997,2703.3,928.2,2.15]

{"sheet":"DecisionTree","index":12,"n_rows":41,"n_cols":8,"rows_kept":41,"cut":false,"hidden":false,"merged":[[39,3,39,4],[40,3,40,4],[33,1,33,2],[32,1,32,2],[31,1,31,2],[37,3,37,4],[38,3,38,4],[19,3,19,4],[20,3,20,4],[12,1,12,2],[13,1,13,2],[14,1,14,2],[17,3,17,4],[18,3,18,4]]}
[null,null,null,null,null,null,null,"Comments"]
[null,null,null,null,"Short-term mortality",null,null,"1. Short-term mortality occurs only in those with complications (the overall mortality is available, but all the mortaliy was assigned to those with complications)"]
[null,null,null,null,{"$f":"IF(p_Complications_HIPEC_live=0,0, p_Short_term_Mortality_HIPEC_live/p_Complications_HIPEC_live)","v":2.3809523809523812E-2},null,null,"2. QALY calculations are available in the sheet QALYCalculation"]
[null,null,null,null,0]
[null,null,null,null,{"$f":"Costs_Complicated_HIPEC_live","v":15858.021953490959}]
[null,null,null,"Complications"]
[null,null,null,{"$f":"p_Complications_HIPEC_live","v":0.26751592356687898}]
[null,null,null,{"$f":"(E3*E4)+(E10*E9)","v":6.3985230608687473},{"$f":"Costs_Complicated_HIPEC_live","v":15858.021953490959}]
[null,null,null,{"$f":"(E3*E5)+(E8*E10)","v":15858.021953490959},{"$f":"QoL_Complicated_HIPEC_live*1/12+QALYCalculation!$F$2","v":6.5545845989387166}]
[null,null,null,null,{"$f":"1-E3","v":0.97619047619047616}]
[null,null,null,null,"No short-term mortality"]
[]
[null,"HIPEC+ CRS + Chemotherapy"]
[null,{"$f":"(D7*D8)+(D19*D20)","v":6.5189396864189373}]
[null,{"$f":"(D7*D9)+(D18*D20)","v":12657.464312287939}]
[]
[]
[null,null,null,{"$f":"Costs_Uncomplicated_HIPEC_live","v":11488.564999848575}]
[null,null,null,{"$f":"QoL_Uncomplicated_HIPEC_live*1/12+QALYCalculation!$F$2","v":6.5629179322720494}]
[null,null,null,{"$f":"1-D7","v":0.73248407643312108}]
[null,null,null,"No complications (no short-term mortality)"]
["Patients with peritoneal metastases from colorectal, gastric, or ovarian cancer"]
[null,null,null,null,"Short-term mortality"]
[null,null,null,null,{"$f":"IF(p_Complications_Control_live=0,0,p_Short_term_Mortality_Control_live/p_Complications_Control_live)","v":0.05}]
[null,null,null,null,0]
[null,null,null,null,{"$f":"Costs_Complicated_Control_live","v":12336.656953642385}]
[null,null,null,"Complications"]
[null,null,null,{"$f":"p_Complications_Control_live","v":0.25157232704402516}]
[null,null,null,{"$f":"(E24*E25)+(E31*E30)","v":3.8436556150770662},{"$f":"Costs_Complicated_Control_live","v":12336.656953642385}]
[null,null,null,{"$f":"(E24*E26)+(E29*E31)","v":12336.656953642383},{"$f":"QoL_Complicated_Control_live*1/12+QALYCalculation!$F$1","v":4.0459532790284909}]
[null,null,null,null,{"$f":"1-E24","v":0.95}]
[null,{"$f":"(D28*D30)+(D38*D40)","v":9066.4344537465113},null,null,"No short-term mortality"]
[null,{"$f":"(D28*D29)+(D39*D40)","v":4.0012976822272943}]
[null,"Control"]
[]
[]
[]
[null,null,null,{"$f":"Costs_Uncomplicated_Control_live","v":7967.2000000000007}]
[null,null,null,{"$f":"QoL_Uncomplicated_Control_live*1/12+QALYCalculation!$F$1","v":4.0542866123618246}]
[null,null,null,{"$f":"1-D28","v":0.7484276729559749}]
[null,null,null,"No complications (no death within 60 days)"]

{"sheet":"Results","index":13,"n_rows":30,"n_cols":11,"rows_kept":30,"cut":false,"hidden":false,"merged":[[11,1,12,1],[11,6,12,6],[11,2,12,2],[11,7,12,7],[27,2,27,3],[17,2,17,3],[11,4,11,5],[11,3,12,3],[11,9,11,10],[11,8,12,8]]}
["Mean results","ICER"]
[null,"Point estimate results (Deterministic results)",null,null,null,null,"Probabilistic results"]
[null,null,"£","QALYs",null,null,null,"£","QALYs"]
[null,{"$f":"Input!B3","v":"HIPEC + CRS + Chemotherapy"},{"$f":"DecisionTree!B15","v":12657.464312287939},{"$f":"DecisionTree!B14","v":6.5189396864189373},null,null,{"$f":"Input!B3","v":"HIPEC + CRS + Chemotherapy"},{"$f":"TEXT(PSA!CX4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!CX1/1000,\"£0,000\") & \" to \" & TEXT(PSA!CX3/1000,\"£0,000\") & \")\"","v":"£12,068\n(95% CI £9,070 to £15,100)"},{"$f":"TEXT(PSA!CY4/1000,\"0.0000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!CY1/1000,\"0.0000\") & \" to \" & TEXT(PSA!CY3/1000,\"0.0000\") & \")\"","v":"6.2438\n(95% CI 1.1617 to 11.1288)"}]
[null,{"$f":"Input!B4","v":"CRS + Chemotherapy"},{"$f":"DecisionTree!B32","v":9066.4344537465113},{"$f":"DecisionTree!B33","v":4.0012976822272943},null,null,{"$f":"Input!B4","v":"CRS + Chemotherapy"},{"$f":"TEXT(PSA!CZ4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!CZ1/1000,\"£0,000\") & \" to \" & TEXT(PSA!CZ3/1000,\"£0,000\") & \")\"","v":"£8,503\n(95% CI £6,404 to £10,610)"},{"$f":"TEXT(PSA!DA4/1000,\"0.0000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!DA1/1000,\"0.0000\") & \" to \" & TEXT(PSA!DA3/1000,\"0.0000\") & \")\"","v":"3.9168\n(95% CI 0.7533 to 6.4947)"}]
[null,"Increment",{"$f":"C4-C5","v":3591.0298585414275},{"$f":"D4-D5","v":2.517642004191643},null,null,"Increment",{"$f":"TEXT(PSA!DC4,\"£0\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!DC1,\"£0\") & \" to \" & TEXT(PSA!DC3,\"£0\") & \")\"","v":"£3565\n(95% CI -£461 to £7592)"},{"$f":"TEXT(PSA!DD4,\"0.0000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!DD1,\"0.0000\") & \" to \" & TEXT(PSA!DD3,\"0.0000\") & \")\"","v":"2.3270\n(95% CI -4.3712 to 8.9286)"}]
[]
[null,"ICER:",{"$f":"C6/D6","v":1426.3464990505768},null,null,null,"ICER:",{"$f":"TEXT(PSA!DE4,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!DE1,\"£0,000\") & \" to \" & TEXT(PSA!DE3,\"£0,000\") & \")\"","v":"£27,674\n(95% CI -£11,132 to £12,164)"}]
[]
[null,"NMB"]
[null,"Point estimate results (Deterministic results)",null,null,null,null,"Probabilistic results"]
[null,"Treatment","Costs","QALYs","Net monetary benefit*",null,"Treatment","Costs","QALYs","Net monetary benefit*"]
[null,null,null,null,20000,30000,null,null,null,20000,30000]
[null,{"$f":"B4","v":"HIPEC + CRS + Chemotherapy"},12657.464312287939,6.5189396864189373,{"$f":"($D$4*E13-$C$4)","v":117721.32941609081},{"$f":"($D$4*F13-$C$4)","v":182910.72628028016},{"$f":"G4","v":"HIPEC + CRS + Chemotherapy"},"£12,068\n(95% CI £9,070 to £15,100)","6.2438\n(95% CI 1.1617 to 11.1288)",{"$f":"TEXT(PSA!EB4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!EB1/1000,\"£0,000\") & \" to \" & TEXT(PSA!EB3/1000,\"£0,000\") & \")\"","v":"£112,809\n(95% CI £10,901 to £210,646)"},{"$f":"TEXT(PSA!EK4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!EK1/1000,\"£0,000\") & \" to \" & TEXT(PSA!EK3/1000,\"£0,000\") & \")\"","v":"£175,247\n(95% CI £22,739 to £322,112)"}]
[null,"CRS + Chemotherapy",9066.4344537465113,4.0012976822272943,{"$f":"($D$5*E13-$C$5)","v":70959.519190799372},{"$f":"($D$5*F13-$C$5)","v":110972.49601307232},"CRS + Chemotherapy","£8,503\n(95% CI £6,404 to £10,610)","3.9168\n(95% CI 0.7533 to 6.4947)",{"$f":"TEXT(PSA!EC4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!EC1/1000,\"£0,000\") & \" to \" & TEXT(PSA!EC3/1000,\"£0,000\") & \")\"","v":"£69,834\n(95% CI £6,426 to £121,347)"},{"$f":"TEXT(PSA!EL4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!EL1/1000,\"£0,000\") & \" to \" & TEXT(PSA!EL3/1000,\"£0,000\") & \")\"","v":"£109,002\n(95% CI £13,994 to £186,246)"}]
[null,"Incremental",{"$f":"C6","v":3591.0298585414275},{"$f":"D14-D15","v":2.517642004191643},{"$f":"($D$4*E13-$C$4)-($D$5*E13-$C$5)","v":46761.81022529144},{"$f":"($D$4*F13-$C$4)-($D$5*F13-$C$5)","v":71938.230267207837},"Incremental",{"$f":"H6","v":"£3565\n(95% CI -£461 to £7592)"},{"$f":"I6","v":"2.3270\n(95% CI -4.3712 to 8.9286)"},{"$f":"TEXT(PSA!ED4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!ED1/1000,\"£0,000\") & \" to \" & TEXT(PSA!ED3/1000,\"£0,000\") & \")\"","v":"£42,975\n(95% CI -£91,066 to £174,648)"},{"$f":"TEXT(PSA!EM4/1000,\"£0,000\") & CHAR(10) & \"(95% CI \" & TEXT(PSA!EM1/1000,\"£0,000\") & \" to \" & TEXT(PSA!EM3/1000,\"£0,000\") & \")\"","v":"£66,245\n(95% CI -£135,100 to £263,789)"}]
[null,"* Calculated at willingness to pay thresholds of £20,000 and £30,000 per QALY gained.\nQALY = quality adjusted life year",null,null,null,null,"* Calculated at willingness to pay thresholds of £20,000 and £30,000 per QALY gained.\nQALY = quality adjusted life year"]
[null,"EVPI","Willingness-to-pay threshold",null,null,null,"Summary of results","Willingness-to-pay threshold","Probability of being cost-effective","Incremental Net Monetary Benefits (Deterministic analysis)","Incremental Net Monetary Benefits (Probabilistic sensitivity analysis)"]
[null,null,20000,30000,null,null,null,20000,{"$f":"PSA!DK25","v":0.7087},{"$f":"E16","v":46761.81022529144},{"$f":"J16","v":"£42,975\n(95% CI -£91,066 to £174,648)"}]
[null,null,{"$f":"PSA!EA9","v":13446853.812321965},{"$f":"PSA!EJ9","v":19650150.171313405},null,null,null,30000,{"$f":"PSA!DK35","v":0.71289999999999998},{"$f":"F16","v":71938.230267207837},{"$f":"K16","v":"£66,245\n(95% CI -£135,100 to £263,789)"}]
[]
[null,"EVPPI"]
[null,{"$f":"PSA!ES2","v":"Parameters"},{"$f":"PSA!ET2","v":"Willingness-to-pay threshold: £20,000"},{"$f":"PSA!EU2","v":"Willingness-to-pay threshold: £30,000"}]
[null,{"$f":"PSA!ES3","v":"Probabilities"},{"$f":"PSA!ET3","v":12293167.829399999},{"$f":"PSA!EU3","v":17944442.9747}]
[null,{"$f":"PSA!ES4","v":"Costs"},{"$f":"PSA!ET4","v":13135071.5495},{"$f":"PSA!EU4","v":19197427.759399999}]
[null,{"$f":"PSA!ES5","v":"Quality of life"},{"$f":"PSA!ET5","v":65363.501100000001},{"$f":"PSA!EU5","v":81127.672399999996}]
[]
[null,"Stability Tests","Willingness to pay threshold"]
[null,null,20000,30000]
[null,null,{"$f":"PSA!FX3","v":1.5609079400950429E-2},{"$f":"PSA!FX4","v":1.515130185867823E-2}]

{"sheet":"PSA","index":14,"n_rows":10004,"n_cols":180,"rows_kept":562,"cut":true,"hidden":false,"merged":[],"bounds":{"rows_first":250,"rows_last":62,"rows_between":250,"halvings":3}}
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:""},{"$f":"IF(BN2=\"\",\"\",AVERAGE(BN5:OFFSET(BN5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BO2=\"\",\"\",AVERAGE(BO5:OFFSET(BO5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BP2=\"\",\"\",AVERAGE(BP5:OFFSET(BP5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BQ2=\"\",\"\",AVERAGE(BQ5:OFFSET(BQ5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BR2=\"\",\"\",AVERAGE(BR5:OFFSET(BR5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BS2=\"\",\"\",AVERAGE(BS5:OFFSET(BS5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BT2=\"\",\"\",AVERAGE(BT5:OFFSET(BT5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BU2=\"\",\"\",AVERAGE(BU5:OFFSET(BU5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BV2=\"\",\"\",AVERAGE(BV5:OFFSET(BV5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BW2=\"\",\"\",AVERAGE(BW5:OFFSET(BW5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BX2=\"\",\"\",AVERAGE(BX5:OFFSET(BX5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BY2=\"\",\"\",AVERAGE(BY5:OFFSET(BY5,Input!$C$10-1,0)))","v":""},{"$f":"IF(BZ2=\"\",\"\",AVERAGE(BZ5:OFFSET(BZ5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CA2=\"\",\"\",AVERAGE(CA5:OFFSET(CA5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CB2=\"\",\"\",AVERAGE(CB5:OFFSET(CB5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CC2=\"\",\"\",AVERAGE(CC5:OFFSET(CC5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CD2=\"\",\"\",AVERAGE(CD5:OFFSET(CD5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CE2=\"\",\"\",AVERAGE(CE5:OFFSET(CE5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CF2=\"\",\"\",AVERAGE(CF5:OFFSET(CF5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CG2=\"\",\"\",AVERAGE(CG5:OFFSET(CG5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CH2=\"\",\"\",AVERAGE(CH5:OFFSET(CH5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CI2=\"\",\"\",AVERAGE(CI5:OFFSET(CI5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CJ2=\"\",\"\",AVERAGE(CJ5:OFFSET(CJ5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CK2=\"\",\"\",AVERAGE(CK5:OFFSET(CK5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CL2=\"\",\"\",AVERAGE(CL5:OFFSET(CL5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CM2=\"\",\"\",AVERAGE(CM5:OFFSET(CM5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CN2=\"\",\"\",AVERAGE(CN5:OFFSET(CN5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CO2=\"\",\"\",AVERAGE(CO5:OFFSET(CO5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CP2=\"\",\"\",AVERAGE(CP5:OFFSET(CP5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CQ2=\"\",\"\",AVERAGE(CQ5:OFFSET(CQ5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CR2=\"\",\"\",AVERAGE(CR5:OFFSET(CR5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CS2=\"\",\"\",AVERAGE(CS5:OFFSET(CS5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CT2=\"\",\"\",AVERAGE(CT5:OFFSET(CT5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CU2=\"\",\"\",AVERAGE(CU5:OFFSET(CU5,Input!$C$10-1,0)))","v":""},{"$f":"IF(CV2=\"\",\"\",AVERAGE(CV5:OFFSET(CV5,Input!$C$10-1,0)))","v":""},null,{"$f":"IF(CX2=\"\",\"\",AVERAGE(CX5:OFFSET(CX5,Input!$C$10-1,0)))","v":12067606.825199841},{"$f":"IF(CY2=\"\",\"\",AVERAGE(CY5:OFFSET(CY5,Input!$C$10-1,0)))","v":6243.8149841092054},{"$f":"IF(CZ2=\"\",\"\",AVERAGE(CZ5:OFFSET(CZ5,Input!$C$10-1,0)))","v":8502905.0077629294},{"$f":"IF(DA2=\"\",\"\",AVERAGE(DA5:OFFSET(DA5,Input!$C$10-1,0)))","v":3916.8232688722292},null,{"$f":"IF(DC2=\"\",\"\",AVERAGE(DC5:OFFSET(DC5,Input!$C$10-1,0)))","v":3564.7018174368559},{"$f":"IF(DD2=\"\",\"\",AVERAGE(DD5:OFFSET(DD5,Input!$C$10-1,0)))","v":2.3269917152370083},{"$f":"IF(DE2=\"\",\"\",AVERAGE(DE5:OFFSET(DE5,Input!$C$10-1,0)))","v":27674.179157492475},null,"results:",null,"Threshold 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cost-effective"},null,null,null,null,null,null,null,null,"Cost-effective",{"$f":"IF(EB2=\"\",\"\",AVERAGE(EB5:OFFSET(EB5,Input!$C$10-1,0)))","v":112808692.85698481},{"$f":"IF(EC2=\"\",\"\",AVERAGE(EC5:OFFSET(EC5,Input!$C$10-1,0)))","v":69833560.369681329},{"$f":"IF(ED2=\"\",\"\",AVERAGE(ED5:OFFSET(ED5,Input!$C$10-1,0)))","v":42975132.487303376},null,{"$f":"IF(EF2=\"\",\"\",AVERAGE(EF5:OFFSET(EF5,Input!$C$10-1,0)))","v":126255546.66930664},{"$f":"IF(EG2=\"\",\"\",AVERAGE(EG5:OFFSET(EG5,Input!$C$10-1,0)))","v":13446853.812321965},null,null,"Cost-effective",{"$f":"IF(EK2=\"\",\"\",AVERAGE(EK5:OFFSET(EK5,Input!$C$10-1,0)))","v":175246842.69807732},{"$f":"IF(EL2=\"\",\"\",AVERAGE(EL5:OFFSET(EL5,Input!$C$10-1,0)))","v":109001793.05840391},{"$f":"IF(EM2=\"\",\"\",AVERAGE(EM5:OFFSET(EM5,Input!$C$10-1,0)))","v":66245049.639673486},null,{"$f":"IF(EO2=\"\",\"\",AVERAGE(EO5:OFFSET(EO5,Input!$C$10-1,0)))","v":194896992.86938995},{"$f":"IF(EP2=\"\",\"\",AVERAGE(EP5:OFFSET(EP5,Input!$C$10-1,0)))","v":19650150.171313405},null,null,"Costs",13135071.5495,19197427.759399999,null,null,{"$f":"IF(EX2=\"\",\"\",AVERAGE(EX5:OFFSET(EX5,Input!$C$10-1,0)))","v":12097313.386818951},{"$f":"IF(EY2=\"\",\"\",AVERAGE(EY5:OFFSET(EY5,Input!$C$10-1,0)))","v":6524.3159167752347},{"$f":"IF(EZ2=\"\",\"\",AVERAGE(EZ5:OFFSET(EZ5,Input!$C$10-1,0)))","v":8516712.4847176056},{"$f":"IF(FA2=\"\",\"\",AVERAGE(FA5:OFFSET(FA5,Input!$C$10-1,0)))","v":4058.7310675778845},"Cost-effective",{"$f":"IF(FC2=\"\",\"\",AVERAGE(FC5:OFFSET(FC5,Input!$C$10-1,0)))","v":118389004.94868547},{"$f":"IF(FD2=\"\",\"\",AVERAGE(FD5:OFFSET(FD5,Input!$C$10-1,0)))","v":72657908.866839886},{"$f":"IF(FE2=\"\",\"\",AVERAGE(FE5:OFFSET(FE5,Input!$C$10-1,0)))","v":45731096.081846133},null,{"$f":"IF(FG2=\"\",\"\",AVERAGE(FG5:OFFSET(FG5,Input!$C$10-1,0)))","v":118453115.95811182},{"$f":"IF(FH2=\"\",\"\",AVERAGE(FH5:OFFSET(FH5,Input!$C$10-1,0)))","v":64111.009426353252},null,null,"Cost-effective",{"$f":"IF(FL2=\"\",\"\",AVERAGE(FL5:OFFSET(FL5,Input!$C$10-1,0)))","v":183632164.11643839},{"$f":"IF(FM2=\"\",\"\",AVERAGE(FM5:OFFSET(FM5,Input!$C$10-1,0)))","v":113245219.54261898},{"$f":"IF(FN2=\"\",\"\",AVERAGE(FN5:OFFSET(FN5,Input!$C$10-1,0)))","v":70386944.573820218},null,{"$f":"IF(FP2=\"\",\"\",AVERAGE(FP5:OFFSET(FP5,Input!$C$10-1,0)))","v":183711584.08800304},{"$f":"IF(FQ2=\"\",\"\",AVERAGE(FQ5:OFFSET(FQ5,Input!$C$10-1,0)))","v":79419.971564708991},null,null,{"$f":"ROW()-2","v":2},43760697.321459793,67414181.604691997,"WTP: 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[2,0.15556324468208005,5.7080123533990166E-4,-0.36182653035423795,0.13251737023539933,1.1205640610418733E-3,0.55290904787445783,11889.614119103358,8259.0108472112261,13652.013281714255,10095.980064928674,0.42213355201518554,0.12381028111100922,0.89920171804325055,0.71034967737043686,0.62544015353601434,0.18471010880914956,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,8823799.2723401412,6941.853311829349,10567216.235286828,1232.6587329236577,null,{"$f":"IF($CX6=\"\",\"\",(CX6-CZ6)/1000)","v":-1743.4169629466869},{"$f":"IF($CX6=\"\",\"\",(CY6-DA6)/1000)","v":5.7091945789056915},{"$f":"IF($CX6=\"\",\"\",DC6/DD6)","v":-305.37003755105081},{"$f":"IF($CX6=\"\",\"\",IF(Threshold*DD6-DC6>0,Intervention,Control))","v":"HIPEC + CRS + Chemotherapy"},{"$f":"Control","v":"CRS + Chemotherapy"},{"$f":"COUNTIF(DF5:OFFSET(DF5,Input!$C$10-1,0),DG6)","v":2815},1,1000,0.39279999999999998,0.60719999999999996,{"$f":"Threshold*CY6-CX6","v":407687399.43742085},{"$f":"Threshold*DA6-CZ6","v":63392307.74013263},{"$f":"DM6-DN6","v":344295091.69728822},null,null,null,null,null,null,null,null,null,null,null,"Population",{"$f":"20000*CY6-CX6","v":130013266.96424684},{"$f":"20000*DA6-CZ6","v":14085958.423186325},{"$f":"EB6-EC6","v":115927308.54106051},{"$f":"IF(OR(EB6=\"\",EC6=\"\"),\"\",IF(EB6>EC6,Intervention,Control))","v":"HIPEC + CRS + Chemotherapy"},{"$f":"IF(OR(EB6=\"\",EC6=\"\"),\"\",MAX(EB6,EC6))","v":130013266.96424684},{"$f":"IF(OR(EB6=\"\",EC6=\"\"),\"\",IF(EE6=EA$5,0,IF(EA$5=Intervention,EC6-EB6,EB6-EC6)))","v":0},null,null,"Population",{"$f":"30000*CY6-CX6","v":199431800.08254033},{"$f":"30000*DA6-CZ6","v":26412545.752422903},{"$f":"EK6-EL6","v":173019254.33011743},{"$f":"IF(OR(EK6=\"\",EL6=\"\"),\"\",IF(EK6>EL6,Intervention,Control))","v":"HIPEC + CRS + Chemotherapy"},{"$f":"IF(OR(EK6=\"\",EL6=\"\"),\"\",MAX(EK6,EL6))","v":199431800.08254033},{"$f":"IF(OR(EK6=\"\",EL6=\"\"),\"\",IF(EN6=EJ$5,0,IF(EJ$5=Intervention,EL6-EK6,EK6-EL6)))","v":0},null,null,null,null,null,null,null,13545144.591580782,8122.5434181658165,6910535.3648960358,4130.2209459813757,"Population",{"$f":"20000*EY6-EX6","v":148905723.77173555},{"$f":"20000*FA6-EZ6","v":75693883.554731488},{"$f":"FC6-FD6","v":73211840.217004061},{"$f":"IF(OR(FC6=\"\",FD6=\"\"),\"\",IF(FC6>FD6,Intervention,Control))","v":"HIPEC + CRS + Chemotherapy"},{"$f":"IF(OR(FC6=\"\",FD6=\"\"),\"\",MAX(FC6,FD6))","v":148905723.77173555},{"$f":"IF(OR(FC6=\"\",FD6=\"\"),\"\",IF(FF6=FB$5,0,IF(FB$5=Intervention,FD6-FC6,FC6-FD6)))","v":0},null,null,"Population",{"$f":"30000*EY6-EX6","v":230131157.95339373},{"$f":"30000*FA6-EZ6","v":116996093.01454525},{"$f":"FL6-FM6","v":113135064.93884848},{"$f":"IF(OR(FL6=\"\",FM6=\"\"),\"\",IF(FL6>FM6,Intervention,Control))","v":"HIPEC + CRS + Chemotherapy"},{"$f":"IF(OR(FL6=\"\",FM6=\"\"),\"\",MAX(FL6,FM6))","v":230131157.95339373},{"$f":"IF(OR(FL6=\"\",FM6=\"\"),\"\",IF(FO6=FK$5,0,IF(FK$5=Intervention,FM6-FL6,FL6-FM6)))","v":0},null,null,4,43325981.630073957,66771028.034000732]
[3,0.14249635954349654,3.2324954380542306E-4,-0.14662831723046393,0.11367906932520355,2.0493938210711217E-3,0.58543970630273301,14705.677077108716,8657.979551894221,15875.637496694892,6406.7865109590393,0.58957554972871384,0.30845119657899622,0.83831698751306838,0.19898336225204755,0.20982643510126087,0.62987874560063639,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,9519754.4328575004,1887.7778879803313,7483196.6785965273,4294.2703914946051,null,2036.5577542609731,-2.4064925035142739,-846.27637579877194,"CRS + Chemotherapy","Checksum:",{"$f":"DH5+DH6","v":10000},2,2000,0.56559999999999999,0.43440000000000001,103746918.84596238,250173026.81107977,-146426107.96511739,null,null,null,null,null,null,null,null,null,null,null,1000,28235803.326749131,78402211.151295573,-50166407.824546441,"CRS + Chemotherapy",78402211.151295573,50166407.824546441,null,null,1000,47113582.206552438,121344915.06624162,-74231332.859689176,"CRS + Chemotherapy",121344915.06624162,74231332.859689176,null,null,null,null,null,null,null,9377759.2030688114,6940.8468456126902,9580949.2117307857,3947.6469836475526,1000,129439177.70918499,69371990.461220264,60067187.247964725,"HIPEC + CRS + Chemotherapy",129439177.70918499,0,null,null,1000,198847646.16531187,108848460.29769579,89999185.867616087,"HIPEC + CRS + Chemotherapy",198847646.16531187,0,null,null,5,44322570.292531237,68257589.395905972]
[4,0.13310628458851542,4.6592552686038904E-4,-0.33689929272657049,0.10877376978250712,7.1952928670040777E-4,0.55617634867835952,20592.274431853166,10713.716800341372,10384.435700364307,9384.4666440280507,0.14300675814874256,0.61665762131637814,0.67489733895333459,0.13091715686540556,0.58895830411366623,0.20302643181307087,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,12028614.903765433,6427.0815056866295,9493237.0479516033,1312.6353751516815,null,2535.3778558138292,5.1144461305349473,495.72872430443226,"HIPEC + CRS + Chemotherapy",{"$f":"\"Probability of \" & Intervention & \" being cost-effective\"","v":"Probability of HIPEC + CRS + Chemotherapy being cost-effective"},{"$f":"DH5/DH7","v":0.71850000000000003},3,3000,0.62,0.38,373596275.43743235,69264885.461149275,304331389.97628307,null,null,null,null,null,null,null,null,null,null,null,"Population EVPI",116513015.20996717,16759470.455082027,99753544.754885137,"HIPEC + CRS + Chemotherapy",116513015.20996717,0,null,null,"Population EVPI",180783830.26683345,29885824.206598841,150898006.06023461,"HIPEC + CRS + Chemotherapy",180783830.26683345,0,null,null,null,null,null,null,null,14190323.576776778,6283.1225820363234,7252500.715544722,4086.705014707622,"Population EVPI",111472128.06394969,74481599.578607723,36990528.485341966,"HIPEC + CRS + Chemotherapy",111472128.06394969,0,null,null,"Population EVPI",174303353.88431293,115348649.72568394,58954704.158628985,"HIPEC + CRS + Chemotherapy",174303353.88431293,0,null,null,6,43208896.205574185,66617619.629664063]
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[198,0.12274759549771885,9.44472783564665E-4,-0.37020417969206648,0.12527015143649106,4.6232127851697741E-4,0.5507254155912531,11840.764888158516,13940.503631111664,13834.130836819442,9365.0526736051143,0.58469220825184554,0.87167572552536243,0.77057736004777189,0.89935694179251147,0.63018879598606004,0.79951784418082072,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,13682765.749240763,7092.0203008273938,9924894.771892488,5124.8927399600834,null,3757.8709773482756,1.9671275608673104,1910.3341603792196,"HIPEC + CRS + Chemotherapy",null,null,null,null,null,null,411838452.30040288,297568669.62571251,114269782.67469037,null,null,null,null,null,null,null,null,null,null,null,null,128157640.26730713,92572960.027309179,35584680.239997953,"HIPEC + CRS + Chemotherapy",128157640.26730713,0,null,null,null,199077843.27558106,143821887.42691001,55255955.848671049,"HIPEC + CRS + Chemotherapy",199077843.27558106,0,null,null,{"$f":"IF(Input!K211=\"\",\"\",Input!K211)","v":""},null,null,null,null,11930831.012690738,7409.7383546931487,9229506.3860608488,4110.2472164266374,null,136263936.08117223,72975437.942471892,63288498.138700336,"HIPEC + CRS + Chemotherapy",136263936.08117223,0,null,null,null,210361319.62810373,114077910.10673827,96283409.521365464,"HIPEC + CRS + Chemotherapy",210361319.62810373,0]
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[9945,0.15247355620979763,8.9759648655811657E-4,-0.39875883423530911,9.8300880322251566E-2,1.2760689707734586E-3,0.55529200150201852,16328.205899414359,8287.5701096330304,10787.553076527403,7903.7856977865058,0.89451255820219266,0.24331849339275194,0.73738489890188974,0.58605564117715103,0.89999109738379435,0.85213129591210002,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,9513554.442688765,10366.813238202785,8187262.5697613275,5480.0681450871944,null,1326.2918729274375,4.8867450931155911,271.405986531998,"HIPEC + CRS + Chemotherapy",null,null,null,null,null,null,612495239.84947824,320616826.13547033,291878413.71400791,null,null,null,null,null,null,null,null,null,null,null,null,197822710.32136694,101414100.33198257,96408609.989384368,"HIPEC + CRS + Chemotherapy",197822710.32136694,0,null,null,null,301490842.70339477,156214781.7828545,145276060.92054027,"HIPEC + CRS + Chemotherapy",301490842.70339477,0,null,null,null,null,null,null,null,14398172.133803288,8290.7501107049047,10457424.091533108,4629.3933222168753,null,151416830.08029482,82130442.352804393,69286387.727490425,"HIPEC + CRS + Chemotherapy",151416830.08029482,0,null,null,null,234324331.18734387,128424375.57497315,105899955.61237071,"HIPEC + CRS + Chemotherapy",234324331.18734387,0]
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{"sheet":"Threshold","index":17,"n_rows":82,"n_cols":159,"rows_kept":82,"cut":false,"hidden":false,"merged":[]}
["Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000",null,"Variable name","Variable value","Costs: Intervention","QALY: Intervention","Costs: Control","QALY: Control","ICER","WTP = 20,000","WTP = 30,000"]
[]
["p_Complications_HIPEC",0,11488564.999848574,6562.9179322720493,9066434.4537465107,4001.2976822272944,48810.274454793034,"Intervention","Intervention",null,"p_Short_term_Mortality_HIPEC",0,12657464.31228794,6560.6886329089921,9066434.4537465107,4001.2976822272944,47596.789155092527,"Intervention","Intervention",null,"p_Ln_HazardRatio_HIPEC",-2,12657464.31228794,12009.516498914354,9066434.4537465107,4001.2976822272944,156573.3464751998,"Intervention","Intervention",null,"p_Complications_Control",0,12657464.31228794,6518.9396864189375,7967200.0000000009,4054.2866123618246,44602.797168854318,"Intervention","Intervention",null,"p_Short_term_Mortality_Control",0,12657464.31228794,6518.9396864189375,9066434.4537465125,4052.1901763031246,45743.96034377483,"Intervention","Intervention",null,"p_MediumMortality_Control",0,12657464.31228794,4266.3589925605638,9066434.4537465107,934.85338784067085,63039.082235856433,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",11100.61536744367,11384782.295638345,6518.9396864189375,9066434.4537465107,4001.2976822272944,48034.492241941029,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",8041.995499894002,10132907.03525115,6518.9396864189375,9066434.4537465107,4001.2976822272944,49286.367502328227,"Intervention","Intervention",null,"Costs_Complicated_Control",8635.659867549668,12657464.31228794,6518.9396864189375,8135366.004415011,4001.2976822272944,45830.741775959948,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",5577.04,12657464.31228794,6518.9396864189375,7277572.5669540586,4001.2976822272944,44972.948338498987,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.1,12657464.31228794,6510.2065123212715,9066434.4537465107,4001.2976822272944,46587.146743338133,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.1,12657464.31228794,6488.3401641259443,9066434.4537465107,4001.2976822272944,46149.819779431578,"Intervention","Intervention",null,"QoL_Complicated_Control",0.1,12657464.31228794,6518.9396864189375,9066434.4537465107,3993.2393719547576,46922.976430742172,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.1,12657464.31228794,6518.9396864189375,9066434.4537465107,3969.8255501518229,47391.25286680086,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.1,12657464.31228794,1115.4886500540661,9066434.4537465107,4001.2976822272944,-61307.210502005983,"Control","Control",null,"QoL_Long_Control",0.1,12657464.31228794,6518.9396864189375,9066434.4537465107,700.1580839689824,112784.60219045768,"Intervention","Intervention"]
["p_Complications_HIPEC",0.05,11707037.847530695,6520.7523191153268,9066434.4537465107,4001.2976822272944,47748.489343976471,"Intervention","Intervention",null,"p_Short_term_Mortality_HIPEC",0.05,12657464.31228794,6232.9594029620566,9066434.4537465107,4001.2976822272944,41042.204556153825,"Intervention","Intervention",null,"p_Ln_HazardRatio_HIPEC",-1.95,12657464.31228794,11945.450228717358,9066434.4537465107,4001.2976822272944,155292.02107125986,"Intervention","Intervention",null,"p_Complications_Control",0.05,12657464.31228794,6518.9396864189375,8185672.8476821193,4002.9774516193283,45847.45323138636,"Intervention","Intervention",null,"p_Short_term_Mortality_Control",0.05,12657464.31228794,6518.9396864189375,9066434.4537465125,3849.8925123516997,49789.913622803317,"Intervention","Intervention",null,"p_MediumMortality_Control",0.05,12657464.31228794,4628.8353685944458,9066434.4537465107,1428.2934755452134,60419.80800244322,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",11600.61536744367,11518540.257421784,6518.9396864189375,9066434.4537465107,4001.2976822272944,47900.734280157587,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",8541.9954998940011,10499149.073467709,6518.9396864189375,9066434.4537465107,4001.2976822272944,48920.125464111668,"Intervention","Intervention",null,"Costs_Complicated_Control",9135.659867549668,12657464.31228794,6518.9396864189375,8261152.1679370236,4001.2976822272944,45956.527939481952,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",6077.04,12657464.31228794,6518.9396864189375,7651786.4034320461,4001.2976822272944,45347.162174976984,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.15000000000000002,12657464.31228794,6511.2946227246694,9066434.4537465107,4001.2976822272944,46608.908951406076,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.15000000000000002,12657464.31228794,6491.3921811110813,9066434.4537465107,4001.2976822272944,46210.860119134319,"Intervention","Intervention",null,"QoL_Complicated_Control",0.15000000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,3994.2351790826401,46903.060288184512,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.15000000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,3972.9439987891392,47328.883894054539,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.15000000000000002,12657464.31228794,1649.4264994972361,9066434.4537465107,4001.2976822272944,-50628.453513142595,"Control","Control",null,"QoL_Long_Control",0.15000000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,1026.3576490142698,106260.61088955193,"Intervention","Intervention"]
["p_Complications_HIPEC",0.1,11925510.695212815,6520.3356524486608,9066434.4537465107,4001.2976822272944,47521.683162961024,"Intervention","Intervention",null,"p_Short_term_Mortality_HIPEC",0.1,12657464.31228794,5905.2301730151203,9066434.4537465107,4001.2976822272944,34487.619957215094,"Intervention","Intervention",null,"p_Ln_HazardRatio_HIPEC",-1.9,12657464.31228794,11878.099210606657,9066434.4537465107,4001.2976822272944,153945.00070904579,"Intervention","Intervention",null,"p_Complications_Control",0.1,12657464.31228794,6518.9396864189375,8404145.6953642387,4002.5607849526609,46074.259412401821,"Intervention","Intervention",null,"p_Short_term_Mortality_Control",0.1,12657464.31228794,6518.9396864189375,9066434.4537465125,3647.5948484002756,53835.866901831811,"Intervention","Intervention",null,"p_MediumMortality_Control",0.1,12657464.31228794,4778.7960459980904,9066434.4537465107,1632.4353581692258,59336.183898035866,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",12100.61536744367,11652298.219205225,6518.9396864189375,9066434.4537465107,4001.2976822272944,47766.976318374145,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",9041.9954998940011,10865391.111684272,6518.9396864189375,9066434.4537465107,4001.2976822272944,48553.88342589511,"Intervention","Intervention",null,"Costs_Complicated_Control",9635.659867549668,12657464.31228794,6518.9396864189375,8386938.3314590361,4001.2976822272944,46082.31410300397,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",6577.04,12657464.31228794,6518.9396864189375,8026000.2399100345,4001.2976822272944,45721.376011454966,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.2,12657464.31228794,6512.3827331280663,9066434.4537465107,4001.2976822272944,46630.671159474019,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.2,12657464.31228794,6494.4441980962201,9066434.4537465107,4001.2976822272944,46271.900458837088,"Intervention","Intervention",null,"QoL_Complicated_Control",0.2,12657464.31228794,6518.9396864189375,9066434.4537465107,3995.230986210523,46883.144145626866,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.2,12657464.31228794,6518.9396864189375,9066434.4537465107,3976.0624474264555,47266.514921308204,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.2,12657464.31228794,2183.3643489404039,9066434.4537465107,4001.2976822272944,-39949.696524279236,"Control","Control",null,"QoL_Long_Control",0.2,12657464.31228794,6518.9396864189375,9066434.4537465107,1352.557214059558,99736.619588646165,"Intervention","Intervention"]
["p_Complications_HIPEC",0.15000000000000002,12143983.542894932,6519.9189857819947,9066434.4537465107,4001.2976822272944,47294.876981945592,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.8499999999999999,12657464.31228794,11807.295031955362,9066434.4537465107,4001.2976822272944,152528.91713601991,"Intervention","Intervention",null,"p_Complications_Control",0.15000000000000002,12657464.31228794,6518.9396864189375,8622618.543046359,4002.1441182859949,46301.065593417283,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.15000000000000002,12657464.31228794,4915.6540988021115,9066434.4537465107,1818.7406018863428,58347.240079773954,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",12600.61536744367,11786056.180988664,6518.9396864189375,9066434.4537465107,4001.2976822272944,47633.218356590703,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",9541.9954998940011,11231633.149900829,6518.9396864189375,9066434.4537465107,4001.2976822272944,48187.641387678552,"Intervention","Intervention",null,"Costs_Complicated_Control",10135.659867549668,12657464.31228794,6518.9396864189375,8512724.4949810486,4001.2976822272944,46208.100266525973,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",7077.04,12657464.31228794,6518.9396864189375,8400214.0763880219,4001.2976822272944,46095.589847932948,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.25,12657464.31228794,6513.4708435314633,9066434.4537465107,4001.2976822272944,46652.433367541962,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.25,12657464.31228794,6497.4962150813571,9066434.4537465107,4001.2976822272944,46332.940798539828,"Intervention","Intervention",null,"QoL_Complicated_Control",0.25,12657464.31228794,6518.9396864189375,9066434.4537465107,3996.2267933384055,46863.228003069205,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.25,12657464.31228794,6518.9396864189375,9066434.4537465107,3979.1808960637718,47204.145948561883,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.25,12657464.31228794,2717.3021983835738,9066434.4537465107,4001.2976822272944,-29270.939535415833,"Control","Control",null,"QoL_Long_Control",0.25,12657464.31228794,6518.9396864189375,9066434.4537465107,1678.7567791048455,93212.628287740416,"Intervention","Intervention"]
["p_Complications_HIPEC",0.2,12362456.390577052,6519.5023191153277,9066434.4537465107,4001.2976822272944,47068.070800930145,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.7999999999999998,12657464.31228794,11732.860645436616,9066434.4537465107,4001.2976822272944,151040.22940564499,"Intervention","Intervention",null,"p_Complications_Control",0.2,12657464.31228794,6518.9396864189375,8841091.3907284774,4001.7274516193274,46527.87177443273,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.2,12657464.31228794,5052.1710962923034,9066434.4537465107,2004.581566066654,57360.760745971565,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",13100.61536744367,11919814.142772103,6518.9396864189375,9066434.4537465107,4001.2976822272944,47499.460394807276,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",10041.995499894001,11597875.188117392,6518.9396864189375,9066434.4537465107,4001.2976822272944,47821.399349461979,"Intervention","Intervention",null,"Costs_Complicated_Control",10635.659867549668,12657464.31228794,6518.9396864189375,8638510.6585030612,4001.2976822272944,46333.886430047991,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",7577.04,12657464.31228794,6518.9396864189375,8774427.9128660094,4001.2976822272944,46469.803684410945,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.3,12657464.31228794,6514.5589539348603,9066434.4537465107,4001.2976822272944,46674.195575609891,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.3,12657464.31228794,6500.548232066496,9066434.4537465107,4001.2976822272944,46393.981138242612,"Intervention","Intervention",null,"QoL_Complicated_Control",0.3,12657464.31228794,6518.9396864189375,9066434.4537465107,3997.222600466288,46843.31186051156,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.3,12657464.31228794,6518.9396864189375,9066434.4537465107,3982.299344701089,47141.776975815548,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.3,12657464.31228794,3251.2400478267423,9066434.4537465107,4001.2976822272944,-18592.18254655246,"Control","Control",null,"QoL_Long_Control",0.3,12657464.31228794,6518.9396864189375,9066434.4537465107,2004.9563441501327,86688.636986834666,"Intervention","Intervention"]
["p_Complications_HIPEC",0.25,12580929.23825917,6519.0856524486608,9066434.4537465107,4001.2976822272944,46841.264619914684,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.7499999999999998,12657464.31228794,11654.609926312978,9066434.4537465107,4001.2976822272944,149475.21502317226,"Intervention","Intervention",null,"p_Complications_Control",0.25,12657464.31228794,6518.9396864189375,9059564.2384105958,4001.3107849526614,46754.677955448176,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.25,12657464.31228794,5194.1012113894276,9066434.4537465107,2197.7914221343344,56335.165926560454,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",13600.61536744367,12053572.104555544,6518.9396864189375,9066434.4537465107,4001.2976822272944,47365.702433023835,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",10541.995499894001,11964117.226333952,6518.9396864189375,9066434.4537465107,4001.2976822272944,47455.157311245421,"Intervention","Intervention",null,"Costs_Complicated_Control",11135.659867549668,12657464.31228794,6518.9396864189375,8764296.8220250737,4001.2976822272944,46459.672593570009,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",8077.04,12657464.31228794,6518.9396864189375,9148641.749343995,4001.2976822272944,46844.017520888927,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.35,12657464.31228794,6515.6470643382572,9066434.4537465107,4001.2976822272944,46695.957783677834,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.35,12657464.31228794,6503.600249051633,9066434.4537465107,4001.2976822272944,46455.021477945353,"Intervention","Intervention",null,"QoL_Complicated_Control",0.35,12657464.31228794,6518.9396864189375,9066434.4537465107,3998.2184075941709,46823.395717953899,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.35,12657464.31228794,6518.9396864189375,9066434.4537465107,3985.4177933384053,47079.408003069213,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.35,12657464.31228794,3785.1778972699108,9066434.4537465107,4001.2976822272944,-7913.4255576890864,"Control","Control",null,"QoL_Long_Control",0.35,12657464.31228794,6518.9396864189375,9066434.4537465107,2331.15590919542,80164.645685928917,"Intervention","Intervention"]
["p_Complications_HIPEC",0.3,12799402.085941289,6518.6689857819947,9066434.4537465107,4001.2976822272944,46614.458438899237,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.6999999999999997,12657464.31228794,11572.347207027668,9066434.4537465107,4001.2976822272944,147829.96063746599,"Intervention","Intervention",null,"p_Complications_Control",0.3,12657464.31228794,6518.9396864189375,9278037.0860927142,4000.894118285994,46981.484136463652,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.3,12657464.31228794,5345.4724812516151,9066434.4537465107,2403.8535481520703,55241.34880344948,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",14100.61536744367,12187330.066338982,6518.9396864189375,9066434.4537465107,4001.2976822272944,47231.944471240393,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",11041.995499894001,12330359.264550513,6518.9396864189375,9066434.4537465107,4001.2976822272944,47088.915273028862,"Intervention","Intervention",null,"Costs_Complicated_Control",11635.659867549668,12657464.31228794,6518.9396864189375,8890082.9855470881,4001.2976822272944,46585.458757092027,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",8577.0400000000009,12657464.31228794,6518.9396864189375,9522855.5858219843,4001.2976822272944,47218.231357366909,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.39999999999999997,12657464.31228794,6516.7351747416542,9066434.4537465107,4001.2976822272944,46717.719991745762,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.39999999999999997,12657464.31228794,6506.6522660367718,9066434.4537465107,4001.2976822272944,46516.061817648137,"Intervention","Intervention",null,"QoL_Complicated_Control",0.39999999999999997,12657464.31228794,6518.9396864189375,9066434.4537465107,3999.2142147220534,46803.479575396253,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.39999999999999997,12657464.31228794,6518.9396864189375,9066434.4537465107,3988.5362419757221,47017.039030322878,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.39999999999999997,12657464.31228794,4319.1157467130797,9066434.4537465107,4001.2976822272944,2765.331431174287,"Intervention","Intervention",null,"QoL_Long_Control",0.39999999999999997,12657464.31228794,6518.9396864189375,9066434.4537465107,2657.3554742407082,73640.654385023154,"Intervention","Intervention"]
["p_Complications_HIPEC",0.35,13017874.933623409,6518.2523191153286,9066434.4537465107,4001.2976822272944,46387.65225788379,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.6499999999999997,12657464.31228794,11485.866787933715,9066434.4537465107,4001.2976822272944,146100.352255587,"Intervention","Intervention",null,"p_Complications_Control",0.35,12657464.31228794,6518.9396864189375,9496509.9337748345,4000.4774516193279,47208.290317479099,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.35,12657464.31228794,5509.9521668033003,9066434.4537465107,2627.7601965032809,54052.809547458965,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",14600.61536744367,12321088.028122421,6518.9396864189375,9066434.4537465107,4001.2976822272944,47098.186509456951,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",11541.995499894001,12696601.302767072,6518.9396864189375,9066434.4537465107,4001.2976822272944,46722.673234812304,"Intervention","Intervention",null,"Costs_Complicated_Control",12135.659867549668,12657464.31228794,6518.9396864189375,9015869.1490690988,4001.2976822272944,46711.24492061403,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",9077.0400000000009,12657464.31228794,6518.9396864189375,9897069.4222999718,4001.2976822272944,47592.445193844906,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.44999999999999996,12657464.31228794,6517.8232851450502,9066434.4537465107,4001.2976822272944,46739.482199813705,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.44999999999999996,12657464.31228794,6509.7042830219089,9066434.4537465107,4001.2976822272944,46577.102157350877,"Intervention","Intervention",null,"QoL_Complicated_Control",0.44999999999999996,12657464.31228794,6518.9396864189375,9066434.4537465107,4000.2100218499363,46783.563432838593,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.44999999999999996,12657464.31228794,6518.9396864189375,9066434.4537465107,3991.6546906130384,46954.670057576557,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.44999999999999996,12657464.31228794,4853.05359615625,9066434.4537465107,4001.2976822272944,13444.08842003769,"Intervention","Intervention",null,"QoL_Long_Control",0.44999999999999996,12657464.31228794,6518.9396864189375,9066434.4537465107,2983.5550392859959,67116.663084117405,"Intervention","Intervention"]
["p_Complications_HIPEC",0.39999999999999997,13236347.781305529,6517.8356524486608,9066434.4537465107,4001.2976822272944,46160.846076868314,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.5999999999999996,12657464.31228794,11394.952422937762,9066434.4537465107,4001.2976822272944,144282.06495566788,"Intervention","Intervention",null,"p_Complications_Control",0.39999999999999997,12657464.31228794,6518.9396864189375,9714982.7814569566,4000.0607849526614,47435.096498494546,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.39999999999999997,12657464.31228794,5691.4437774678954,9066434.4537465107,2874.8252253028563,52741.341184759338,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",15100.61536744367,12454845.989905862,6518.9396864189375,9066434.4537465107,4001.2976822272944,46964.428547673509,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",12041.995499894001,13062843.340983635,6518.9396864189375,9066434.4537465107,4001.2976822272944,46356.431196595746,"Intervention","Intervention",null,"Costs_Complicated_Control",12635.659867549668,12657464.31228794,6518.9396864189375,9141655.3125911132,4001.2976822272944,46837.031084136048,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",9577.0400000000009,12657464.31228794,6518.9396864189375,10271283.258777959,4001.2976822272944,47966.659030322888,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.49999999999999994,12657464.31228794,6518.9113955484481,9066434.4537465107,4001.2976822272944,46761.244407881662,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.49999999999999994,12657464.31228794,6512.7563000070477,9066434.4537465107,4001.2976822272944,46638.142497053661,"Intervention","Intervention",null,"QoL_Complicated_Control",0.49999999999999994,12657464.31228794,6518.9396864189375,9066434.4537465107,4001.2058289778183,46763.647290280947,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.49999999999999994,12657464.31228794,6518.9396864189375,9066434.4537465107,3994.7731392503551,46892.301084830222,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.49999999999999994,12657464.31228794,5386.9914455994185,9066434.4537465107,4001.2976822272944,24122.845408901063,"Intervention","Intervention",null,"QoL_Long_Control",0.49999999999999994,12657464.31228794,6518.9396864189375,9066434.4537465107,3309.7546043312832,60592.671783211656,"Intervention","Intervention"]
["p_Complications_HIPEC",0.44999999999999996,13454820.628987648,6517.4189857819938,9066434.4537465107,4001.2976822272944,45934.039895852868,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.5499999999999996,12657464.31228794,11299.376778772132,9066434.4537465107,4001.2976822272944,142370.55207235529,"Intervention","Intervention",null,"p_Complications_Control",0.44999999999999996,12657464.31228794,6518.9396864189375,9933455.6291390751,3999.6441182859944,47661.902679510007,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.44999999999999996,12657464.31228794,5894.4916146365804,9066434.4537465107,3151.2348045339422,51274.106343511332,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",15600.61536744367,12588603.951689299,6518.9396864189375,9066434.4537465107,4001.2976822272944,46830.670585890082,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",12541.995499894001,13429085.379200194,6518.9396864189375,9066434.4537465107,4001.2976822272944,45990.189158379173,"Intervention","Intervention",null,"Costs_Complicated_Control",13135.659867549668,12657464.31228794,6518.9396864189375,9267441.4761131238,4001.2976822272944,46962.817247658051,"Intervention","Intervention",null,"Costs_Uncomplicated_Control",10077.040000000001,12657464.31228794,6518.9396864189375,10645497.095255947,4001.2976822272944,48340.872866800884,"Intervention","Intervention",null,"QoL_Complicated_HIPEC",0.54999999999999993,12657464.31228794,6519.9995059518451,9066434.4537465107,4001.2976822272944,46783.006615949591,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.54999999999999993,12657464.31228794,6515.8083169921856,9066434.4537465107,4001.2976822272944,46699.182836756401,"Intervention","Intervention",null,"QoL_Complicated_Control",0.54999999999999993,12657464.31228794,6518.9396864189375,9066434.4537465107,4002.2016361057008,46743.731147723302,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.54999999999999993,12657464.31228794,6518.9396864189375,9066434.4537465107,3997.8915878876714,46829.932112083887,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.54999999999999993,12657464.31228794,5920.929295042587,9066434.4537465107,4001.2976822272944,34801.602397764436,"Intervention","Intervention",null,"QoL_Long_Control",0.54999999999999993,12657464.31228794,6518.9396864189375,9066434.4537465107,3635.9541693765705,54068.680482305906,"Intervention","Intervention"]
["p_Complications_HIPEC",0.49999999999999994,13673293.476669766,6517.0023191153277,9066434.4537465107,4001.2976822272944,45707.233714837421,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.4999999999999996,12657464.31228794,11198.900866543288,9066434.4537465107,4001.2976822272944,140361.03382777848,"Intervention","Intervention",null,"p_Complications_Control",0.49999999999999994,12657464.31228794,6518.9396864189375,10151928.476821192,3999.2274516193274,47888.708860525454,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.49999999999999994,12657464.31228794,6124.6651469632643,9066434.4537465107,3464.5706671942057,49610.859736839746,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",16100.61536744367,12722361.913472742,6518.9396864189375,9066434.4537465107,4001.2976822272944,46696.912624106641,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",13041.995499894001,13795327.417416755,6518.9396864189375,9066434.4537465107,4001.2976822272944,45623.947120162615,"Intervention","Intervention",null,"Costs_Complicated_Control",13635.659867549668,12657464.31228794,6518.9396864189375,9393227.6396351364,4001.2976822272944,47088.603411180069,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.6,12657464.31228794,6521.0876163552421,9066434.4537465107,4001.2976822272944,46804.768824017534,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.6,12657464.31228794,6518.8603339773244,9066434.4537465107,4001.2976822272944,46760.223176459171,"Intervention","Intervention",null,"QoL_Complicated_Control",0.6,12657464.31228794,6518.9396864189375,9066434.4537465107,4003.1974432335833,46723.815005165656,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.6,12657464.31228794,6518.9396864189375,9066434.4537465107,4001.0100365249882,46767.563139337552,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.6,12657464.31228794,6454.8671444857564,9066434.4537465107,4001.2976822272944,45480.359386627824,"Intervention","Intervention",null,"QoL_Long_Control",0.6,12657464.31228794,6518.9396864189375,9066434.4537465107,3962.15373442186,47544.689181400114,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.4499999999999995,12657464.31228794,11093.273444135091,9066434.4537465107,4001.2976822272944,138248.48537961452,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.54999999999999993,12657464.31228794,6389.0003624949213,9066434.4537465107,3824.4109231648426,47700.758928060139,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",16600.615367443672,12856119.875256179,6518.9396864189375,9066434.4537465107,4001.2976822272944,46563.154662323199,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",13541.995499894001,14161569.455633314,6518.9396864189375,9066434.4537465107,4001.2976822272944,45257.705081946056,"Intervention","Intervention",null,"Costs_Complicated_Control",14135.659867549668,12657464.31228794,6518.9396864189375,9519013.8031571489,4001.2976822272944,47214.389574702087,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.65,12657464.31228794,6522.175726758639,9066434.4537465107,4001.2976822272944,46826.531032085477,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.65,12657464.31228794,6521.9123509624615,9066434.4537465107,4001.2976822272944,46821.263516161911,"Intervention","Intervention",null,"QoL_Complicated_Control",0.65,12657464.31228794,6518.9396864189375,9066434.4537465107,4004.1932503614667,46703.898862607995,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.65,12657464.31228794,6518.9396864189375,9066434.4537465107,4004.1284851623045,46705.194166591231,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.65,12657464.31228794,6988.8049939289258,9066434.4537465107,4001.2976822272944,56159.116375491198,"Intervention","Intervention",null,"QoL_Long_Control",0.65,12657464.31228794,6518.9396864189375,9066434.4537465107,4288.3532994671468,41020.697880494379,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.3999999999999995,12657464.31228794,10982.230387972655,9066434.4537465107,4001.2976822272944,136027.62425636576,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.6,12657464.31228794,6696.5495152850654,9066434.4537465107,4243.0784307875783,45478.391831408298,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",17100.615367443672,12989877.837039622,6518.9396864189375,9066434.4537465107,4001.2976822272944,46429.396700539757,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",14041.995499894001,14527811.493849877,6518.9396864189375,9066434.4537465107,4001.2976822272944,44891.463043729498,"Intervention","Intervention",null,"Costs_Complicated_Control",14635.659867549668,12657464.31228794,6518.9396864189375,9644799.9666791614,4001.2976822272944,47340.17573822409,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.70000000000000007,12657464.31228794,6523.2638371620369,9066434.4537465107,4001.2976822272944,46848.29324015342,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.70000000000000007,12657464.31228794,6524.9643679476003,9066434.4537465107,4001.2976822272944,46882.303855864695,"Intervention","Intervention",null,"QoL_Complicated_Control",0.70000000000000007,12657464.31228794,6518.9396864189375,9066434.4537465107,4005.1890574893491,46683.982720050335,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.70000000000000007,12657464.31228794,6518.9396864189375,9066434.4537465107,4007.2469337996217,46642.825193844881,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.70000000000000007,12657464.31228794,7522.7428433720979,9066434.4537465107,4001.2976822272944,66837.873364354615,"Intervention","Intervention",null,"QoL_Long_Control",0.70000000000000007,12657464.31228794,6518.9396864189375,9066434.4537465107,4614.552864512435,34496.70657958863,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.3499999999999994,12657464.31228794,10865.494032575816,9066434.4537465107,4001.2976822272944,133692.89714842901,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.65,12657464.31228794,7059.085647768713,9066434.4537465107,4736.5998651115506,42858.685794601828,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",17600.615367443672,13123635.798823059,6518.9396864189375,9066434.4537465107,4001.2976822272944,46295.638738756315,"Intervention","Intervention",null,"Costs_Uncomplicated_HIPEC",14541.995499894001,14894053.532066436,6518.9396864189375,9066434.4537465107,4001.2976822272944,44525.22100551294,"Intervention","Intervention",null,"Costs_Complicated_Control",15135.659867549668,12657464.31228794,6518.9396864189375,9770586.1302011739,4001.2976822272944,47465.961901746108,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.75000000000000011,12657464.31228794,6524.3519475654339,9066434.4537465107,4001.2976822272944,46870.055448221363,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.75000000000000011,12657464.31228794,6528.0163849327373,9066434.4537465107,4001.2976822272944,46943.344195567435,"Intervention","Intervention",null,"QoL_Complicated_Control",0.75000000000000011,12657464.31228794,6518.9396864189375,9066434.4537465107,4006.1848646172311,46664.066577492689,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.75000000000000011,12657464.31228794,6518.9396864189375,9066434.4537465107,4010.3653824369385,46580.45622109856,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.75000000000000011,12657464.31228794,8056.6806928152664,9066434.4537465107,4001.2976822272944,77516.630353218017,"Intervention","Intervention",null,"QoL_Long_Control",0.75000000000000011,12657464.31228794,6518.9396864189375,9066434.4537465107,4940.7524295577232,27972.715278682852,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.2999999999999994,12657464.31228794,10742.772476250851,9066434.4537465107,4001.2976822272944,131238.46602192969,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.70000000000000007,12657464.31228794,7492.0109712523545,9066434.4537465107,5325.9422987528496,39730.343591448647,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",18100.615367443672,13257393.760606499,6518.9396864189375,9066434.4537465107,4001.2976822272944,46161.880776972874,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"Costs_Complicated_Control",15635.659867549668,12657464.31228794,6518.9396864189375,9896372.2937231865,4001.2976822272944,47591.748065268112,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.80000000000000016,12657464.31228794,6525.4400579688299,9066434.4537465107,4001.2976822272944,46891.817656289306,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.80000000000000016,12657464.31228794,6531.0684019178761,9066434.4537465107,4001.2976822272944,47004.384535270219,"Intervention","Intervention",null,"QoL_Complicated_Control",0.80000000000000016,12657464.31228794,6518.9396864189375,9066434.4537465107,4007.1806717451136,46644.150434935043,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.80000000000000016,12657464.31228794,6518.9396864189375,9066434.4537465107,4013.4838310742548,46518.087248352225,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.80000000000000016,12657464.31228794,8590.6185422584331,9066434.4537465107,4001.2976822272944,88195.387342081332,"Intervention","Intervention",null,"QoL_Long_Control",0.80000000000000016,12657464.31228794,6518.9396864189375,9066434.4537465107,5266.9519946030123,21448.723977777074,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.2499999999999993,12657464.31228794,10613.758851184126,9066434.4537465107,4001.2976822272944,128658.19352059522,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.75000000000000011,12657464.31228794,8015.5245245393762,9066434.4537465107,6038.6027387930026,35947.405856386016,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",18600.615367443672,13391151.722389938,6518.9396864189375,9066434.4537465107,4001.2976822272944,46028.122815189432,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"QoL_Complicated_HIPEC",0.8500000000000002,12657464.31228794,6526.5281683722269,9066434.4537465107,4001.2976822272944,46913.579864357234,"Intervention","Intervention",null,"QoL_Uncomplicated_HIPEC",0.8500000000000002,12657464.31228794,6534.1204189030132,9066434.4537465107,4001.2976822272944,47065.42487497296,"Intervention","Intervention",null,"QoL_Complicated_Control",0.8500000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,4008.176478872997,46624.234292377383,"Intervention","Intervention",null,"QoL_Uncomplicated_Control",0.8500000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,4016.6022797115711,46455.718275605905,"Intervention","Intervention",null,"QoL_Long_HIPEC",0.8500000000000002,12657464.31228794,9124.5563917016061,9066434.4537465107,4001.2976822272944,98874.144330944793,"Intervention","Intervention",null,"QoL_Long_Control",0.8500000000000002,12657464.31228794,6518.9396864189375,9066434.4537465107,5593.1515596482996,14924.732676871325,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.1999999999999993,12657464.31228794,10478.130556112794,9066434.4537465107,4001.2976822272944,125945.62761916853,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.80000000000000016,12657464.31228794,8656.1130409042435,9066434.4537465107,6910.6376480916351,31318.477997710695,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",19100.615367443672,13524909.684173377,6518.9396864189375,9066434.4537465107,4001.2976822272944,45894.36485340599,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.1499999999999992,12657464.31228794,10335.548449653532,9066434.4537465107,4001.2976822272944,123093.9854899833,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.8500000000000002,12657464.31228794,9448.4390732535812,9066434.4537465107,7989.2332552616544,25593.086501297104,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",19600.615367443672,13658667.645956816,6518.9396864189375,9066434.4537465107,4001.2976822272944,45760.606891622563,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.0999999999999992,12657464.31228794,10185.656002272512,9066434.4537465107,4001.2976822272944,120096.1365423629,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.90000000000000024,12657464.31228794,10437.711935687059,9066434.4537465107,9335.9331239374187,18444.546376451355,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",20100.615367443672,13792425.607740257,6518.9396864189375,9066434.4537465107,4001.2976822272944,45626.848929839121,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-1.0499999999999992,12657464.31228794,10028.078404775773,9066434.4537465107,4001.2976822272944,116944.58459242813,"Intervention","Intervention",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_MediumMortality_Control",0.95000000000000029,12657464.31228794,11682.639837771947,9066434.4537465107,11030.656901282788,9448.628871241759,"Intervention","Intervention",null,"Costs_Complicated_HIPEC",20600.615367443672,13926183.569523696,6518.9396864189375,9066434.4537465107,4001.2976822272944,45493.09096805568,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.99999999999999911,12657464.31228794,9862.4216310910779,9066434.4537465107,4001.2976822272944,113631.44911873424,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.94999999999999907,12657464.31228794,9688.2714529974528,9066434.4537465107,4001.2976822272944,110148.44555686174,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.89999999999999902,12657464.31228794,9505.1924043388954,9066434.4537465107,4001.2976822272944,106486.86458369061,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.84999999999999898,12657464.31228794,9312.7266921321298,9066434.4537465107,4001.2976822272944,102637.55033955527,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.79999999999999893,12657464.31228794,9110.3930518457255,9066434.4537465107,4001.2976822272944,98590.877533827195,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.74999999999999889,12657464.31228794,8897.6855439880928,9066434.4537465107,4001.2976822272944,94336.727376674549,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.69999999999999885,12657464.31228794,8674.072288995183,9066434.4537465107,4001.2976822272944,89864.462276816324,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.6499999999999988,12657464.31228794,8438.9941372545763,9066434.4537465107,4001.2976822272944,85162.89924200422,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.59999999999999876,12657464.31228794,8191.8632709401782,9066434.4537465107,4001.2976822272944,80220.281915716259,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.54999999999999871,12657464.31228794,7932.0617341614879,9066434.4537465107,4001.2976822272944,75024.251180142441,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.49999999999999872,12657464.31228794,7658.9398877519789,9066434.4537465107,4001.2976822272944,69561.814251952266,"Intervention","Intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"p_Ln_HazardRatio_HIPEC",-0.44999999999999873,12657464.31228794,7371.8147848328035,9066434.4537465107,4001.2976822272944,63819.312193568752,"Intervention","Intervention"]
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{"sheet":"ThresholdSummary","index":18,"n_rows":61,"n_cols":86,"rows_kept":61,"cut":false,"hidden":false,"merged":[]}
["Variable","Distribution","Range tested","Step","Threshold (WTP: £20,000 per QALY)","Threshold (WTP: £30,000 per QALY)",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(OFFSET($A$2,COLUMN()-COLUMN($AA$1),0)=\"\",\"\",OFFSET($A$2,COLUMN()-COLUMN($AA$1),0))","v":"Complications (HIPEC + CRS)"},"Short-term mortality (HIPEC + CRS)","Survival ln (hazard ratio)","Complications (Control)","Short-term mortality (Control)","5-year mortality (Control)","Cost (HIPEC + CRS) Complicated","Cost (HIPEC + CRS) Uncomplicated","Cost (Control) Complicated","Cost (Control) Uncomplicated","QoL (complicated HIPEC + CRS) (Short-term)","QoL (uncomplicated HIPEC + CRS) (Short-term)","QoL (Complicated CRS) (Short-term)","QoL (Uncomplicated CRS) (Short-term)","QoL (Long-term) HIPEC","QoL (Long-term) Control","","","","","","","","","","","","","","","","",{"$f":"IF(OFFSET($A$2,COLUMN()-COLUMN($AA$1),0)=\"\",\"\",OFFSET($A$2,COLUMN()-COLUMN($AA$1),0))","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A12=\"\",\"\",Input!A12)","v":"Complications (HIPEC + CRS)"},{"$f":"IF($A2=\"\",\"\",Input!B12)","v":"Beta"},{"$f":"IF($A2=\"\",\"\",ROUND(Input!E12,2) & \" to \" & ROUND(Input!F12,2))","v":"0 to 0.5"},{"$f":"IF($A2=\"\",\"\",Input!G12)","v":0.05},{"$f":"IF($A2=\"\",\"\",OFFSET($AA$12,0,ROW()-ROW(E$2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF($A2=\"\",\"\",OFFSET($AA$14,0,ROW()-ROW(F$2)))","v":"Intervention is cost-effective for the range tested"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",\"WTP = £20,000\")","v":"WTP = £20,000"},"WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","","","","","","","","","","","","","","","","",{"$f":"IF(BG$1=\"\",\"\",\"WTP = £20,000\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A13=\"\",\"\",Input!A13)","v":"Short-term mortality (HIPEC + CRS)"},{"$f":"IF($A3=\"\",\"\",Input!B13)","v":"Beta"},{"$f":"IF($A3=\"\",\"\",ROUND(Input!E13,2) & \" to \" & ROUND(Input!F13,2))","v":"0 to 0.1"},{"$f":"IF($A3=\"\",\"\",Input!G13)","v":0.05},{"$f":"IF($A3=\"\",\"\",OFFSET($AA$12,0,ROW()-ROW(E$2)))","v":"Intervention is cost-effective for the range tested"},"Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AI$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AJ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AK$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AL$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AM$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AN$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AO$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Control"},{"$f":"IF(AP$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AQ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AR$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AS$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AT$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AU$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AV$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AW$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AX$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AY$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AZ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BI$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BJ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BK$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BL$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BM$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BN$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BO$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BP$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BQ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BR$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BS$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BT$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BU$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BV$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BW$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BX$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BY$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BZ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""}]
[{"$f":"IF(Input!A14=\"\",\"\",Input!A14)","v":"Survival ln (hazard ratio)"},{"$f":"IF($A4=\"\",\"\",Input!B14)","v":"Continuous"},{"$f":"IF($A4=\"\",\"\",ROUND(Input!E14,2) & \" to \" & ROUND(Input!F14,2))","v":"-2 to 2"},{"$f":"IF($A4=\"\",\"\",Input!G14)","v":0.05},"Control becomes cost-effective when value is 0","Control becomes cost-effective when value is 0",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Control",null,null,null,null,null,null,null,null,null,null,null,"Intervention"]
[{"$f":"IF(Input!A15=\"\",\"\",Input!A15)","v":"Complications (Control)"},{"$f":"IF($A5=\"\",\"\",Input!B15)","v":"Beta"},{"$f":"IF($A5=\"\",\"\",ROUND(Input!E15,2) & \" to \" & ROUND(Input!F15,2))","v":"0 to 0.5"},{"$f":"IF($A5=\"\",\"\",Input!G15)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested"]
[{"$f":"IF(Input!A16=\"\",\"\",Input!A16)","v":"Short-term mortality (Control)"},{"$f":"IF($A6=\"\",\"\",Input!B16)","v":"Beta"},{"$f":"IF($A6=\"\",\"\",ROUND(Input!E16,2) & \" to \" & ROUND(Input!F16,2))","v":"0 to 0.1"},{"$f":"IF($A6=\"\",\"\",Input!G16)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",\"WTP = £30,000\")","v":"WTP = £30,000"},"WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","","","","","","","","","","","","","","","","",{"$f":"IF(BG$1=\"\",\"\",\"WTP = £30,000\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A17=\"\",\"\",Input!A17)","v":"5-year mortality (Control)"},{"$f":"IF($A7=\"\",\"\",Input!B17)","v":"Beta"},{"$f":"IF($A7=\"\",\"\",ROUND(Input!E17,2) & \" to \" & ROUND(Input!F17,2))","v":"0 to 1"},{"$f":"IF($A7=\"\",\"\",Input!G17)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AI$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AJ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AK$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AL$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AM$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AN$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AO$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Control"},{"$f":"IF(AP$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":"Intervention"},{"$f":"IF(AQ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AR$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AS$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AT$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AU$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AV$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AW$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AX$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AY$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(AZ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BI$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BJ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BK$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BL$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BM$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BN$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BO$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BP$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BQ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BR$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BS$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BT$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BU$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BV$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BW$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BX$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BY$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(BZ$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CA$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CB$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CC$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CD$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CE$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CF$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CG$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""},{"$f":"IF(CH$1=\"\",\"\",_xlfn.UNIQUE(_xlfn._xlws.FILTER(OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10)<>\"\")))","v":""}]
[{"$f":"IF(Input!A18=\"\",\"\",Input!A18)","v":"Cost (HIPEC + CRS) Complicated"},{"$f":"IF($A8=\"\",\"\",Input!B18)","v":"Uniform"},{"$f":"IF($A8=\"\",\"\",ROUND(Input!E18,2) & \" to \" & ROUND(Input!F18,2))","v":"11100.62 to 20615.43"},{"$f":"IF($A8=\"\",\"\",Input!G18)","v":500},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Control",null,null,null,null,null,null,null,null,null,null,null,"Intervention"]
[{"$f":"IF(Input!A19=\"\",\"\",Input!A19)","v":"Cost (HIPEC + CRS) Uncomplicated"},{"$f":"IF($A9=\"\",\"\",Input!B19)","v":"Uniform"},{"$f":"IF($A9=\"\",\"\",ROUND(Input!E19,2) & \" to \" & ROUND(Input!F19,2))","v":"8042 to 14935.13"},{"$f":"IF($A9=\"\",\"\",Input!G19)","v":500},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested"]
[{"$f":"IF(Input!A20=\"\",\"\",Input!A20)","v":"Cost (Control) Complicated"},{"$f":"IF($A10=\"\",\"\",Input!B20)","v":"Uniform"},{"$f":"IF($A10=\"\",\"\",ROUND(Input!E20,2) & \" to \" & ROUND(Input!F20,2))","v":"8635.66 to 16037.65"},{"$f":"IF($A10=\"\",\"\",Input!G20)","v":500},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",\"Threshold level\")","v":"Threshold level"},"Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","Threshold level","","","","","","","","","","","","","","","","",{"$f":"IF(BG$1=\"\",\"\",\"Threshold level\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A21=\"\",\"\",Input!A21)","v":"Cost (Control) Uncomplicated"},{"$f":"IF($A11=\"\",\"\",Input!B21)","v":"Uniform"},{"$f":"IF($A11=\"\",\"\",ROUND(Input!E21,2) & \" to \" & ROUND(Input!F21,2))","v":"5577.04 to 10357.36"},{"$f":"IF($A11=\"\",\"\",Input!G21)","v":500},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",\"WTP = £20,000\")","v":"WTP = £20,000"},"WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","WTP = £20,000","","","","","","","","","","","","","","","","",{"$f":"IF(BG$1=\"\",\"\",\"WTP = £20,000\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A22=\"\",\"\",Input!A22)","v":"QoL (complicated HIPEC + CRS) (Short-term)"},{"$f":"IF($A12=\"\",\"\",Input!B22)","v":"Beta"},{"$f":"IF($A12=\"\",\"\",ROUND(Input!E22,2) & \" to \" & ROUND(Input!F22,2))","v":"0.1 to 0.9"},{"$f":"IF($A12=\"\",\"\",Input!G22)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",IF(AA$4=\"\",AA$3 & \" is cost-effective for the range tested\",AA$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AA$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AB$1=\"\",\"\",IF(AB$4=\"\",AB$3 & \" is cost-effective for the range tested\",AB$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AB$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AC$1=\"\",\"\",IF(AC$4=\"\",AC$3 & \" is cost-effective for the range tested\",AC$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AC$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Control becomes cost-effective when value is 0"},{"$f":"IF(AD$1=\"\",\"\",IF(AD$4=\"\",AD$3 & \" is cost-effective for the range tested\",AD$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AD$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AE$1=\"\",\"\",IF(AE$4=\"\",AE$3 & \" is cost-effective for the range tested\",AE$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AE$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AF$1=\"\",\"\",IF(AF$4=\"\",AF$3 & \" is cost-effective for the range tested\",AF$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AF$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AG$1=\"\",\"\",IF(AG$4=\"\",AG$3 & \" is cost-effective for the range tested\",AG$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AG$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AH$1=\"\",\"\",IF(AH$4=\"\",AH$3 & \" is cost-effective for the range tested\",AH$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AH$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AI$1=\"\",\"\",IF(AI$4=\"\",AI$3 & \" is cost-effective for the range tested\",AI$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AI$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AJ$1=\"\",\"\",IF(AJ$4=\"\",AJ$3 & \" is cost-effective for the range tested\",AJ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AJ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AK$1=\"\",\"\",IF(AK$4=\"\",AK$3 & \" is cost-effective for the range tested\",AK$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AK$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AL$1=\"\",\"\",IF(AL$4=\"\",AL$3 & \" is cost-effective for the range tested\",AL$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AL$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AM$1=\"\",\"\",IF(AM$4=\"\",AM$3 & \" is cost-effective for the range tested\",AM$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AM$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AN$1=\"\",\"\",IF(AN$4=\"\",AN$3 & \" is cost-effective for the range tested\",AN$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AN$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AO$1=\"\",\"\",IF(AO$4=\"\",AO$3 & \" is cost-effective for the range tested\",AO$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AO$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention becomes cost-effective when value is 0.4"},{"$f":"IF(AP$1=\"\",\"\",IF(AP$4=\"\",AP$3 & \" is cost-effective for the range tested\",AP$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AP$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AQ$1=\"\",\"\",IF(AQ$4=\"\",AQ$3 & \" is cost-effective for the range tested\",AQ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AQ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AR$1=\"\",\"\",IF(AR$4=\"\",AR$3 & \" is cost-effective for the range tested\",AR$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AR$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AS$1=\"\",\"\",IF(AS$4=\"\",AS$3 & \" is cost-effective for the range tested\",AS$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AS$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AT$1=\"\",\"\",IF(AT$4=\"\",AT$3 & \" is cost-effective for the range tested\",AT$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AT$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AU$1=\"\",\"\",IF(AU$4=\"\",AU$3 & \" is cost-effective for the range tested\",AU$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AU$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AV$1=\"\",\"\",IF(AV$4=\"\",AV$3 & \" is cost-effective for the range tested\",AV$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AV$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AW$1=\"\",\"\",IF(AW$4=\"\",AW$3 & \" is cost-effective for the range tested\",AW$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AW$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AX$1=\"\",\"\",IF(AX$4=\"\",AX$3 & \" is cost-effective for the range tested\",AX$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AX$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AY$1=\"\",\"\",IF(AY$4=\"\",AY$3 & \" is cost-effective for the range tested\",AY$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AY$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AZ$1=\"\",\"\",IF(AZ$4=\"\",AZ$3 & \" is cost-effective for the range tested\",AZ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AZ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BA$1=\"\",\"\",IF(BA$4=\"\",BA$3 & \" is cost-effective for the range tested\",BA$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BA$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BB$1=\"\",\"\",IF(BB$4=\"\",BB$3 & \" is cost-effective for the range tested\",BB$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BB$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BC$1=\"\",\"\",IF(BC$4=\"\",BC$3 & \" is cost-effective for the range tested\",BC$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BC$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BD$1=\"\",\"\",IF(BD$4=\"\",BD$3 & \" is cost-effective for the range tested\",BD$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BD$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BE$1=\"\",\"\",IF(BE$4=\"\",BE$3 & \" is cost-effective for the range tested\",BE$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BE$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BF$1=\"\",\"\",IF(BF$4=\"\",BF$3 & \" is cost-effective for the range tested\",BF$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BF$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BG$1=\"\",\"\",IF(BG$4=\"\",BG$3 & \" is cost-effective for the range tested\",BG$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BG$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BH$1=\"\",\"\",IF(BH$4=\"\",BH$3 & \" is cost-effective for the range tested\",BH$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BH$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BI$1=\"\",\"\",IF(BI$4=\"\",BI$3 & \" is cost-effective for the range tested\",BI$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BI$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BJ$1=\"\",\"\",IF(BJ$4=\"\",BJ$3 & \" is cost-effective for the range tested\",BJ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BJ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BK$1=\"\",\"\",IF(BK$4=\"\",BK$3 & \" is cost-effective for the range tested\",BK$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BK$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BL$1=\"\",\"\",IF(BL$4=\"\",BL$3 & \" is cost-effective for the range tested\",BL$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BL$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BM$1=\"\",\"\",IF(BM$4=\"\",BM$3 & \" is cost-effective for the range tested\",BM$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BM$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BN$1=\"\",\"\",IF(BN$4=\"\",BN$3 & \" is cost-effective for the range tested\",BN$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BN$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BO$1=\"\",\"\",IF(BO$4=\"\",BO$3 & \" is cost-effective for the range tested\",BO$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BO$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BP$1=\"\",\"\",IF(BP$4=\"\",BP$3 & \" is cost-effective for the range tested\",BP$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BP$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BQ$1=\"\",\"\",IF(BQ$4=\"\",BQ$3 & \" is cost-effective for the range tested\",BQ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BQ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BR$1=\"\",\"\",IF(BR$4=\"\",BR$3 & \" is cost-effective for the range tested\",BR$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BR$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BS$1=\"\",\"\",IF(BS$4=\"\",BS$3 & \" is cost-effective for the range tested\",BS$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BS$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BT$1=\"\",\"\",IF(BT$4=\"\",BT$3 & \" is cost-effective for the range tested\",BT$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BT$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BU$1=\"\",\"\",IF(BU$4=\"\",BU$3 & \" is cost-effective for the range tested\",BU$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BU$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BV$1=\"\",\"\",IF(BV$4=\"\",BV$3 & \" is cost-effective for the range tested\",BV$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BV$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BW$1=\"\",\"\",IF(BW$4=\"\",BW$3 & \" is cost-effective for the range tested\",BW$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BW$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BX$1=\"\",\"\",IF(BX$4=\"\",BX$3 & \" is cost-effective for the range tested\",BX$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BX$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BY$1=\"\",\"\",IF(BY$4=\"\",BY$3 & \" is cost-effective for the range tested\",BY$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BY$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BZ$1=\"\",\"\",IF(BZ$4=\"\",BZ$3 & \" is cost-effective for the range tested\",BZ$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BZ$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CA$1=\"\",\"\",IF(CA$4=\"\",CA$3 & \" is cost-effective for the range tested\",CA$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CA$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CB$1=\"\",\"\",IF(CB$4=\"\",CB$3 & \" is cost-effective for the range tested\",CB$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CB$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CC$1=\"\",\"\",IF(CC$4=\"\",CC$3 & \" is cost-effective for the range tested\",CC$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CC$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CD$1=\"\",\"\",IF(CD$4=\"\",CD$3 & \" is cost-effective for the range tested\",CD$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CD$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CE$1=\"\",\"\",IF(CE$4=\"\",CE$3 & \" is cost-effective for the range tested\",CE$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CE$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CF$1=\"\",\"\",IF(CF$4=\"\",CF$3 & \" is cost-effective for the range tested\",CF$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CF$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CG$1=\"\",\"\",IF(CG$4=\"\",CG$3 & \" is cost-effective for the range tested\",CG$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CG$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CH$1=\"\",\"\",IF(CH$4=\"\",CH$3 & \" is cost-effective for the range tested\",CH$4 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CH$4,OFFSET(Threshold!$H$3:$H$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""}]
[{"$f":"IF(Input!A23=\"\",\"\",Input!A23)","v":"QoL (uncomplicated HIPEC + CRS) (Short-term)"},{"$f":"IF($A13=\"\",\"\",Input!B23)","v":"Beta"},{"$f":"IF($A13=\"\",\"\",ROUND(Input!E23,2) & \" to \" & ROUND(Input!F23,2))","v":"0.1 to 0.9"},{"$f":"IF($A13=\"\",\"\",Input!G23)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",\"WTP = £30,000\")","v":"WTP = £30,000"},"WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","WTP = £30,000","","","","","","","","","","","","","","","","",{"$f":"IF(BG$1=\"\",\"\",\"WTP = £30,000\")","v":""},"","","","","","","","","","","","","","","","","","","","","","","","","","",""]
[{"$f":"IF(Input!A24=\"\",\"\",Input!A24)","v":"QoL (Complicated CRS) (Short-term)"},{"$f":"IF($A14=\"\",\"\",Input!B24)","v":"Beta"},{"$f":"IF($A14=\"\",\"\",ROUND(Input!E24,2) & \" to \" & ROUND(Input!F24,2))","v":"0.1 to 0.9"},{"$f":"IF($A14=\"\",\"\",Input!G24)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(AA$1=\"\",\"\",IF(AA$8=\"\",AA$7 & \" is cost-effective for the range tested\",AA$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AA$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AB$1=\"\",\"\",IF(AB$8=\"\",AB$7 & \" is cost-effective for the range tested\",AB$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AB$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AC$1=\"\",\"\",IF(AC$8=\"\",AC$7 & \" is cost-effective for the range tested\",AC$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AC$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Control becomes cost-effective when value is 0"},{"$f":"IF(AD$1=\"\",\"\",IF(AD$8=\"\",AD$7 & \" is cost-effective for the range tested\",AD$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AD$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AE$1=\"\",\"\",IF(AE$8=\"\",AE$7 & \" is cost-effective for the range tested\",AE$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AE$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AF$1=\"\",\"\",IF(AF$8=\"\",AF$7 & \" is cost-effective for the range tested\",AF$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AF$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AG$1=\"\",\"\",IF(AG$8=\"\",AG$7 & \" is cost-effective for the range tested\",AG$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AG$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AH$1=\"\",\"\",IF(AH$8=\"\",AH$7 & \" is cost-effective for the range tested\",AH$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AH$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AI$1=\"\",\"\",IF(AI$8=\"\",AI$7 & \" is cost-effective for the range tested\",AI$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AI$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AJ$1=\"\",\"\",IF(AJ$8=\"\",AJ$7 & \" is cost-effective for the range tested\",AJ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AJ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AK$1=\"\",\"\",IF(AK$8=\"\",AK$7 & \" is cost-effective for the range tested\",AK$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AK$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AL$1=\"\",\"\",IF(AL$8=\"\",AL$7 & \" is cost-effective for the range tested\",AL$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AL$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AM$1=\"\",\"\",IF(AM$8=\"\",AM$7 & \" is cost-effective for the range tested\",AM$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AM$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AN$1=\"\",\"\",IF(AN$8=\"\",AN$7 & \" is cost-effective for the range tested\",AN$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AN$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AO$1=\"\",\"\",IF(AO$8=\"\",AO$7 & \" is cost-effective for the range tested\",AO$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AO$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention becomes cost-effective when value is 0.4"},{"$f":"IF(AP$1=\"\",\"\",IF(AP$8=\"\",AP$7 & \" is cost-effective for the range tested\",AP$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AP$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":"Intervention is cost-effective for the range tested"},{"$f":"IF(AQ$1=\"\",\"\",IF(AQ$8=\"\",AQ$7 & \" is cost-effective for the range tested\",AQ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AQ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AR$1=\"\",\"\",IF(AR$8=\"\",AR$7 & \" is cost-effective for the range tested\",AR$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AR$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AS$1=\"\",\"\",IF(AS$8=\"\",AS$7 & \" is cost-effective for the range tested\",AS$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AS$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AT$1=\"\",\"\",IF(AT$8=\"\",AT$7 & \" is cost-effective for the range tested\",AT$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AT$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AU$1=\"\",\"\",IF(AU$8=\"\",AU$7 & \" is cost-effective for the range tested\",AU$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AU$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AV$1=\"\",\"\",IF(AV$8=\"\",AV$7 & \" is cost-effective for the range tested\",AV$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AV$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AW$1=\"\",\"\",IF(AW$8=\"\",AW$7 & \" is cost-effective for the range tested\",AW$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AW$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AX$1=\"\",\"\",IF(AX$8=\"\",AX$7 & \" is cost-effective for the range tested\",AX$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AX$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AY$1=\"\",\"\",IF(AY$8=\"\",AY$7 & \" is cost-effective for the range tested\",AY$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AY$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(AZ$1=\"\",\"\",IF(AZ$8=\"\",AZ$7 & \" is cost-effective for the range tested\",AZ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(AZ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BA$1=\"\",\"\",IF(BA$8=\"\",BA$7 & \" is cost-effective for the range tested\",BA$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BA$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BB$1=\"\",\"\",IF(BB$8=\"\",BB$7 & \" is cost-effective for the range tested\",BB$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BB$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BC$1=\"\",\"\",IF(BC$8=\"\",BC$7 & \" is cost-effective for the range tested\",BC$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BC$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BD$1=\"\",\"\",IF(BD$8=\"\",BD$7 & \" is cost-effective for the range tested\",BD$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BD$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BE$1=\"\",\"\",IF(BE$8=\"\",BE$7 & \" is cost-effective for the range tested\",BE$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BE$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BF$1=\"\",\"\",IF(BF$8=\"\",BF$7 & \" is cost-effective for the range tested\",BF$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BF$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BG$1=\"\",\"\",IF(BG$8=\"\",BG$7 & \" is cost-effective for the range tested\",BG$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BG$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BH$1=\"\",\"\",IF(BH$8=\"\",BH$7 & \" is cost-effective for the range tested\",BH$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BH$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BI$1=\"\",\"\",IF(BI$8=\"\",BI$7 & \" is cost-effective for the range tested\",BI$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BI$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BJ$1=\"\",\"\",IF(BJ$8=\"\",BJ$7 & \" is cost-effective for the range tested\",BJ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BJ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BK$1=\"\",\"\",IF(BK$8=\"\",BK$7 & \" is cost-effective for the range tested\",BK$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BK$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BL$1=\"\",\"\",IF(BL$8=\"\",BL$7 & \" is cost-effective for the range tested\",BL$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BL$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BM$1=\"\",\"\",IF(BM$8=\"\",BM$7 & \" is cost-effective for the range tested\",BM$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BM$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BN$1=\"\",\"\",IF(BN$8=\"\",BN$7 & \" is cost-effective for the range tested\",BN$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BN$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BO$1=\"\",\"\",IF(BO$8=\"\",BO$7 & \" is cost-effective for the range tested\",BO$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BO$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BP$1=\"\",\"\",IF(BP$8=\"\",BP$7 & \" is cost-effective for the range tested\",BP$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BP$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BQ$1=\"\",\"\",IF(BQ$8=\"\",BQ$7 & \" is cost-effective for the range tested\",BQ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BQ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BR$1=\"\",\"\",IF(BR$8=\"\",BR$7 & \" is cost-effective for the range tested\",BR$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BR$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BS$1=\"\",\"\",IF(BS$8=\"\",BS$7 & \" is cost-effective for the range tested\",BS$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BS$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BT$1=\"\",\"\",IF(BT$8=\"\",BT$7 & \" is cost-effective for the range tested\",BT$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BT$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BU$1=\"\",\"\",IF(BU$8=\"\",BU$7 & \" is cost-effective for the range tested\",BU$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BU$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BV$1=\"\",\"\",IF(BV$8=\"\",BV$7 & \" is cost-effective for the range tested\",BV$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BV$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BW$1=\"\",\"\",IF(BW$8=\"\",BW$7 & \" is cost-effective for the range tested\",BW$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BW$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BX$1=\"\",\"\",IF(BX$8=\"\",BX$7 & \" is cost-effective for the range tested\",BX$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BX$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BY$1=\"\",\"\",IF(BY$8=\"\",BY$7 & \" is cost-effective for the range tested\",BY$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BY$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(BZ$1=\"\",\"\",IF(BZ$8=\"\",BZ$7 & \" is cost-effective for the range tested\",BZ$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(BZ$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CA$1=\"\",\"\",IF(CA$8=\"\",CA$7 & \" is cost-effective for the range tested\",CA$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CA$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CB$1=\"\",\"\",IF(CB$8=\"\",CB$7 & \" is cost-effective for the range tested\",CB$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CB$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CC$1=\"\",\"\",IF(CC$8=\"\",CC$7 & \" is cost-effective for the range tested\",CC$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CC$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CD$1=\"\",\"\",IF(CD$8=\"\",CD$7 & \" is cost-effective for the range tested\",CD$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CD$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CE$1=\"\",\"\",IF(CE$8=\"\",CE$7 & \" is cost-effective for the range tested\",CE$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CE$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CF$1=\"\",\"\",IF(CF$8=\"\",CF$7 & \" is cost-effective for the range tested\",CF$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CF$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CG$1=\"\",\"\",IF(CG$8=\"\",CG$7 & \" is cost-effective for the range tested\",CG$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CG$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""},{"$f":"IF(CH$1=\"\",\"\",IF(CH$8=\"\",CH$7 & \" is cost-effective for the range tested\",CH$8 & \" becomes cost-effective when value is \" & ROUND(INDEX(OFFSET(Threshold!$B$3:$B$61,0,(COLUMN()-COLUMN($AA$1))*10),MATCH(CH$8,OFFSET(Threshold!$I$3:$I$61,0,(COLUMN()-COLUMN($AA$1))*10),0)),2)))","v":""}]
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[{"$f":"IF(Input!A26=\"\",\"\",Input!A26)","v":"QoL (Long-term) HIPEC"},{"$f":"IF($A16=\"\",\"\",Input!B26)","v":"Beta"},{"$f":"IF($A16=\"\",\"\",ROUND(Input!E26,2) & \" to \" & ROUND(Input!F26,2))","v":"0.1 to 0.9"},{"$f":"IF($A16=\"\",\"\",Input!G26)","v":0.05},"Intervention becomes cost-effective when value is 0.4","Intervention becomes cost-effective when value is 0.4"]
[{"$f":"IF(Input!A27=\"\",\"\",Input!A27)","v":"QoL (Long-term) Control"},{"$f":"IF($A17=\"\",\"\",Input!B27)","v":"Beta"},{"$f":"IF($A17=\"\",\"\",ROUND(Input!E27,2) & \" to \" & ROUND(Input!F27,2))","v":"0.1 to 0.9"},{"$f":"IF($A17=\"\",\"\",Input!G27)","v":0.05},"Intervention is cost-effective for the range tested","Intervention is cost-effective for the range tested"]
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[{"$f":"IF(Input!A51=\"\",\"\",Input!A51)","v":""},{"$f":"IF($A41=\"\",\"\",Input!B51)","v":""},{"$f":"IF($A41=\"\",\"\",ROUND(Input!E51,2) & \" to \" & ROUND(Input!F51,2))","v":""},{"$f":"IF($A41=\"\",\"\",Input!G51)","v":""},"",""]
[{"$f":"IF(Input!A52=\"\",\"\",Input!A52)","v":""},{"$f":"IF($A42=\"\",\"\",Input!B52)","v":""},{"$f":"IF($A42=\"\",\"\",ROUND(Input!E52,2) & \" to \" & ROUND(Input!F52,2))","v":""},{"$f":"IF($A42=\"\",\"\",Input!G52)","v":""},"",""]
[{"$f":"IF(Input!A53=\"\",\"\",Input!A53)","v":""},{"$f":"IF($A43=\"\",\"\",Input!B53)","v":""},{"$f":"IF($A43=\"\",\"\",ROUND(Input!E53,2) & \" to \" & ROUND(Input!F53,2))","v":""},{"$f":"IF($A43=\"\",\"\",Input!G53)","v":""},"",""]
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{"sheet":"TornadoPreparation","index":20,"n_rows":102,"n_cols":13,"rows_kept":102,"cut":false,"hidden":false,"merged":[]}
["Parameter","Minimum","Maximum","Minimum ICER","Maximum ICER","Order inverted",null,null,null,null,"Label","Low","High"]
[{"$f":"IF(ROW(A2)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A1)-1,0),\"\")","v":"Complications (HIPEC + CRS)"},{"$f":"IF(ROW(A2)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A1)-1,4),\"\")","v":0},{"$f":"IF(ROW(A2)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A1)-1,5),\"\")","v":0.5},{"$f":"IF(ROW(A2)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A1)-1)*10)),\"\")","v":45707.233714837421},{"$f":"IF(ROW(A2)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A1)-1)*10)),\"\")","v":48810.274454793034},{"$f":"IF(A2=\"\",\"\",OFFSET($A$1,VariableNumber-ROW(F2)+2,0))","v":"QoL (Long-term) Control"},{"$f":"IF(A2=\"\",\"\",OFFSET($A$1,VariableNumber-ROW(F2)+2,1))","v":0.1},{"$f":"IF(A2=\"\",\"\",OFFSET($A$1,VariableNumber-ROW(F2)+2,2))","v":0.9},{"$f":"IF(A2=\"\",\"\",OFFSET($A$1,VariableNumber-ROW(F2)+2,3))","v":14924.732676871325},{"$f":"IF(A2=\"\",\"\",OFFSET($A$1,VariableNumber-ROW(F2)+2,4))","v":112784.60219045768},{"$f":"IF(F2=\"\",\"\",F2 & \" (\" & ROUND(G2,2) & \" to \" & ROUND(H2,2) & \")\")","v":"QoL (Long-term) Control (0.1 to 0.9)"},{"$f":"IF(D2=\"\",\"\",I2)","v":14924.732676871325},{"$f":"IF(E2=\"\",\"\",J2)","v":112784.60219045768}]
[{"$f":"IF(ROW(A3)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A2)-1,0),\"\")","v":"Short-term mortality (HIPEC + CRS)"},{"$f":"IF(ROW(A3)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A2)-1,4),\"\")","v":0},{"$f":"IF(ROW(A3)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A2)-1,5),\"\")","v":0.1},{"$f":"IF(ROW(A3)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A2)-1)*10)),\"\")","v":34487.619957215094},{"$f":"IF(ROW(A3)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A2)-1)*10)),\"\")","v":47596.789155092527},"QoL (Long-term) HIPEC",0.1,0.9,-61307.210502005983,98874.144330944793,{"$f":"IF(F3=\"\",\"\",F3 & \" (\" & ROUND(G3,2) & \" to \" & ROUND(H3,2) & \")\")","v":"QoL (Long-term) HIPEC (0.1 to 0.9)"},{"$f":"IF(D3=\"\",\"\",I3)","v":-61307.210502005983},{"$f":"IF(E3=\"\",\"\",J3)","v":98874.144330944793}]
[{"$f":"IF(ROW(A4)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A3)-1,0),\"\")","v":"Survival ln (hazard ratio)"},{"$f":"IF(ROW(A4)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A3)-1,4),\"\")","v":-2},{"$f":"IF(ROW(A4)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A3)-1,5),\"\")","v":2},{"$f":"IF(ROW(A4)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A3)-1)*10)),\"\")","v":-64322.463133019097},{"$f":"IF(ROW(A4)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A3)-1)*10)),\"\")","v":156573.3464751998},"QoL (Uncomplicated CRS) (Short-term)",0.1,0.9,46455.718275605905,47391.25286680086,"QoL (Uncomplicated CRS) (Short-term) (0.1 to 0.9)",46455.718275605905,47391.25286680086]
[{"$f":"IF(ROW(A5)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A4)-1,0),\"\")","v":"Complications (Control)"},{"$f":"IF(ROW(A5)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A4)-1,4),\"\")","v":0},{"$f":"IF(ROW(A5)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A4)-1,5),\"\")","v":0.5},{"$f":"IF(ROW(A5)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A4)-1)*10)),\"\")","v":44602.797168854318},{"$f":"IF(ROW(A5)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A4)-1)*10)),\"\")","v":47888.708860525454},"QoL (Complicated CRS) (Short-term)",0.1,0.9,46624.234292377383,46922.976430742172,"QoL (Complicated CRS) (Short-term) (0.1 to 0.9)",46624.234292377383,46922.976430742172]
[{"$f":"IF(ROW(A6)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A5)-1,0),\"\")","v":"Short-term mortality (Control)"},{"$f":"IF(ROW(A6)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A5)-1,4),\"\")","v":0},{"$f":"IF(ROW(A6)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A5)-1,5),\"\")","v":0.1},{"$f":"IF(ROW(A6)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A5)-1)*10)),\"\")","v":45743.96034377483},{"$f":"IF(ROW(A6)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A5)-1)*10)),\"\")","v":53835.866901831811},"QoL (uncomplicated HIPEC + CRS) (Short-term)",0.1,0.9,46149.819779431578,47065.42487497296,"QoL (uncomplicated HIPEC + CRS) (Short-term) (0.1 to 0.9)",46149.819779431578,47065.42487497296]
[{"$f":"IF(ROW(A7)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A6)-1,0),\"\")","v":"5-year mortality (Control)"},{"$f":"IF(ROW(A7)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A6)-1,4),\"\")","v":0},{"$f":"IF(ROW(A7)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A6)-1,5),\"\")","v":1},{"$f":"IF(ROW(A7)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A6)-1)*10)),\"\")","v":9448.628871241759},{"$f":"IF(ROW(A7)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A6)-1)*10)),\"\")","v":63039.082235856433},"QoL (complicated HIPEC + CRS) (Short-term)",0.1,0.9,46587.146743338133,46913.579864357234,"QoL (complicated HIPEC + CRS) (Short-term) (0.1 to 0.9)",46587.146743338133,46913.579864357234]
[{"$f":"IF(ROW(A8)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A7)-1,0),\"\")","v":"Cost (HIPEC + CRS) Complicated"},{"$f":"IF(ROW(A8)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A7)-1,4),\"\")","v":11100.61536744367},{"$f":"IF(ROW(A8)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A7)-1,5),\"\")","v":20615.428539538247},{"$f":"IF(ROW(A8)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A7)-1)*10)),\"\")","v":45493.09096805568},{"$f":"IF(ROW(A8)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A7)-1)*10)),\"\")","v":48034.492241941029},"Cost (Control) Uncomplicated",5577.04,10357.36,44972.948338498987,48340.872866800884,"Cost (Control) Uncomplicated (5577.04 to 10357.36)",44972.948338498987,48340.872866800884]
[{"$f":"IF(ROW(A9)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A8)-1,0),\"\")","v":"Cost (HIPEC + CRS) Uncomplicated"},{"$f":"IF(ROW(A9)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A8)-1,4),\"\")","v":8041.995499894002},{"$f":"IF(ROW(A9)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A8)-1,5),\"\")","v":14935.134499803147},{"$f":"IF(ROW(A9)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A8)-1)*10)),\"\")","v":44525.22100551294},{"$f":"IF(ROW(A9)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A8)-1)*10)),\"\")","v":49286.367502328227},"Cost (Control) Complicated",8635.659867549668,16037.654039735102,45830.741775959948,47591.748065268112,"Cost (Control) Complicated (8635.66 to 16037.65)",45830.741775959948,47591.748065268112]
[{"$f":"IF(ROW(A10)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A9)-1,0),\"\")","v":"Cost (Control) Complicated"},{"$f":"IF(ROW(A10)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A9)-1,4),\"\")","v":8635.659867549668},{"$f":"IF(ROW(A10)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A9)-1,5),\"\")","v":16037.654039735102},{"$f":"IF(ROW(A10)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A9)-1)*10)),\"\")","v":45830.741775959948},{"$f":"IF(ROW(A10)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A9)-1)*10)),\"\")","v":47591.748065268112},"Cost (HIPEC + CRS) Uncomplicated",8041.995499894002,14935.134499803147,44525.22100551294,49286.367502328227,"Cost (HIPEC + CRS) Uncomplicated (8042 to 14935.13)",44525.22100551294,49286.367502328227]
[{"$f":"IF(ROW(A11)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A10)-1,0),\"\")","v":"Cost (Control) Uncomplicated"},{"$f":"IF(ROW(A11)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A10)-1,4),\"\")","v":5577.04},{"$f":"IF(ROW(A11)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A10)-1,5),\"\")","v":10357.36},{"$f":"IF(ROW(A11)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A10)-1)*10)),\"\")","v":44972.948338498987},{"$f":"IF(ROW(A11)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A10)-1)*10)),\"\")","v":48340.872866800884},"Cost (HIPEC + CRS) Complicated",11100.61536744367,20615.428539538247,45493.09096805568,48034.492241941029,"Cost (HIPEC + CRS) Complicated (11100.62 to 20615.43)",45493.09096805568,48034.492241941029]
[{"$f":"IF(ROW(A12)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A11)-1,0),\"\")","v":"QoL (complicated HIPEC + CRS) (Short-term)"},{"$f":"IF(ROW(A12)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A11)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A12)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A11)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A12)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A11)-1)*10)),\"\")","v":46587.146743338133},{"$f":"IF(ROW(A12)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A11)-1)*10)),\"\")","v":46913.579864357234},"5-year mortality (Control)",0,1,9448.628871241759,63039.082235856433,"5-year mortality (Control) (0 to 1)",9448.628871241759,63039.082235856433]
[{"$f":"IF(ROW(A13)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A12)-1,0),\"\")","v":"QoL (uncomplicated HIPEC + CRS) (Short-term)"},{"$f":"IF(ROW(A13)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A12)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A13)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A12)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A13)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A12)-1)*10)),\"\")","v":46149.819779431578},{"$f":"IF(ROW(A13)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A12)-1)*10)),\"\")","v":47065.42487497296},"Short-term mortality (Control)",0,0.1,45743.96034377483,53835.866901831811,"Short-term mortality (Control) (0 to 0.1)",45743.96034377483,53835.866901831811]
[{"$f":"IF(ROW(A14)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A13)-1,0),\"\")","v":"QoL (Complicated CRS) (Short-term)"},{"$f":"IF(ROW(A14)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A13)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A14)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A13)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A14)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A13)-1)*10)),\"\")","v":46624.234292377383},{"$f":"IF(ROW(A14)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A13)-1)*10)),\"\")","v":46922.976430742172},"Complications (Control)",0,0.5,44602.797168854318,47888.708860525454,"Complications (Control) (0 to 0.5)",44602.797168854318,47888.708860525454]
[{"$f":"IF(ROW(A15)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A14)-1,0),\"\")","v":"QoL (Uncomplicated CRS) (Short-term)"},{"$f":"IF(ROW(A15)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A14)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A15)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A14)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A15)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A14)-1)*10)),\"\")","v":46455.718275605905},{"$f":"IF(ROW(A15)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A14)-1)*10)),\"\")","v":47391.25286680086},"Survival ln (hazard ratio)",-2,2,-64322.463133019097,156573.3464751998,"Survival ln (hazard ratio) (-2 to 2)",-64322.463133019097,156573.3464751998]
[{"$f":"IF(ROW(A16)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A15)-1,0),\"\")","v":"QoL (Long-term) HIPEC"},{"$f":"IF(ROW(A16)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A15)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A16)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A15)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A16)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A15)-1)*10)),\"\")","v":-61307.210502005983},{"$f":"IF(ROW(A16)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A15)-1)*10)),\"\")","v":98874.144330944793},"Short-term mortality (HIPEC + CRS)",0,0.1,34487.619957215094,47596.789155092527,"Short-term mortality (HIPEC + CRS) (0 to 0.1)",34487.619957215094,47596.789155092527]
[{"$f":"IF(ROW(A17)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A16)-1,0),\"\")","v":"QoL (Long-term) Control"},{"$f":"IF(ROW(A17)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A16)-1,4),\"\")","v":0.1},{"$f":"IF(ROW(A17)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A16)-1,5),\"\")","v":0.9},{"$f":"IF(ROW(A17)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A16)-1)*10)),\"\")","v":14924.732676871325},{"$f":"IF(ROW(A17)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A16)-1)*10)),\"\")","v":112784.60219045768},"Complications (HIPEC + CRS)",0,0.5,45707.233714837421,48810.274454793034,"Complications (HIPEC + CRS) (0 to 0.5)",45707.233714837421,48810.274454793034]
[{"$f":"IF(ROW(A18)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A17)-1,0),\"\")","v":""},{"$f":"IF(ROW(A18)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A17)-1,4),\"\")","v":""},{"$f":"IF(ROW(A18)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A17)-1,5),\"\")","v":""},{"$f":"IF(ROW(A18)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A17)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A18)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A17)-1)*10)),\"\")","v":""},"","","","","","","",""]
[{"$f":"IF(ROW(A19)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A18)-1,0),\"\")","v":""},{"$f":"IF(ROW(A19)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A18)-1,4),\"\")","v":""},{"$f":"IF(ROW(A19)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A18)-1,5),\"\")","v":""},{"$f":"IF(ROW(A19)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A18)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A19)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A18)-1)*10)),\"\")","v":""},"","","","","","","",""]
[{"$f":"IF(ROW(A20)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A19)-1,0),\"\")","v":""},{"$f":"IF(ROW(A20)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A19)-1,4),\"\")","v":""},{"$f":"IF(ROW(A20)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A19)-1,5),\"\")","v":""},{"$f":"IF(ROW(A20)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A19)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A20)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A19)-1)*10)),\"\")","v":""},"","","","","","","",""]
[{"$f":"IF(ROW(A21)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A20)-1,0),\"\")","v":""},{"$f":"IF(ROW(A21)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A20)-1,4),\"\")","v":""},{"$f":"IF(ROW(A21)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A20)-1,5),\"\")","v":""},{"$f":"IF(ROW(A21)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A20)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A21)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A20)-1)*10)),\"\")","v":""},"","","","","","","",""]
[{"$f":"IF(ROW(A22)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A21)-1,0),\"\")","v":""},{"$f":"IF(ROW(A22)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A21)-1,4),\"\")","v":""},{"$f":"IF(ROW(A22)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A21)-1,5),\"\")","v":""},{"$f":"IF(ROW(A22)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A21)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A22)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A21)-1)*10)),\"\")","v":""},"","","","","","","",""]
[{"$f":"IF(ROW(A23)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A22)-1,0),\"\")","v":""},{"$f":"IF(ROW(A23)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A22)-1,4),\"\")","v":""},{"$f":"IF(ROW(A23)-2<VariableNumber,OFFSET(Input!$A$12,ROW(TornadoPreparation!A22)-1,5),\"\")","v":""},{"$f":"IF(ROW(A23)-2<VariableNumber,MIN(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A22)-1)*10)),\"\")","v":""},{"$f":"IF(ROW(A23)-2<VariableNumber,MAX(OFFSET(Threshold!$G:$G,0,(ROW(TornadoPreparation!A22)-1)*10)),\"\")","v":""},"","","","","","","",""]
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