Spironolactone to improve exercise tolerance in people with permanent  atrial fibrillation and preserved ejection fraction: the IMPRESS-AF RCT

Shantsila, Eduard; Shahid, Farhan; Sun, Yongzhong; Deeks, Jonathan J; Haynes, Ronnie; Calvert, Melanie; Fisher, James P; Kirchhof, Paulus; Gill, Paramjit S; Lip, Gregory YH

doi:10.3310/eme07040

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Treatment with spironolactone, compared with placebo, did not improve exercise tolerance at 2 years for people experiencing atrial fibrillation and preserved ejection fraction.

Eduard Shantsila , Farhan Shahid , Yongzhong Sun, Jonathan J Deeks , Ronnie Haynes , Melanie Calvert , James P Fisher , Paulus Kirchhof, Paramjit S Gill & Gregory YH Lip .

Detailed Author information
Detailed Author information

Eduard Shantsila ^1,^2,^3,^4,^*, Farhan Shahid ^1,², Yongzhong Sun ⁵, Jonathan J Deeks ^5,⁶, Ronnie Haynes ^2,⁷, Melanie Calvert ^5,⁸, James P Fisher ⁹, Paulus Kirchhof ^1,^2,¹⁰, Paramjit S Gill ¹¹, Gregory YH Lip ⁴

¹ Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK
² Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
³ North Worcestershire VTS, Health Education England (West Midlands), St Helens and Knowsley Teaching Hospitals NHS Trust, Whiston, Merseyside, UK
⁴ Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK
⁵ NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK
⁶ Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
⁷ The Surgery, Birmingham, UK
⁸ Centre for Patient Reported Outcomes Research (CPROR), Institute of Applied Health Research, University of Birmingham, Birmingham, UK
⁹ Faculty of Medical and Health Sciences, Department of Physiology, University of Auckland, Auckland, New Zealand
¹⁰ University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
¹¹ Academic Unit of Primary Care, Warwick Medical School, University of Warwick, Coventry, UK
^* Corresponding author Email: Eduard.Shantsila@liverpool.ac.uk

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