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Gabapentin did not reduce pain scores or improve other outcomes in women with chronic pelvic pain, and was associated with an increase in serious adverse effects.

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Catherine A Hewitt 1, Katy Vincent 2, Lee J Middleton 1, Liana Romaniuk 3, Magda Koscielniak 4, Ann M Doust 4, Judy Birch 5, Heather Whalley 3, Jane P Daniels 6,7, Andrew W Horne 4,*

1 Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
2 Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, UK
3 Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
4 Medical Research Council Centre for Reproductive Health, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, UK
5 Pelvic Pain Support Network, Poole, UK
6 Nottingham Clinical Trials Unit, School of Medicine, University of Nottingham, Nottingham, UK
7 Nottingham Health Sciences Partners, Queen’s Medical Centre, Nottingham, UK
* Corresponding author Email: Andrew.horne@ed.ac.uk

Declared competing interests of authors: Andrew W Horne reports grants from the National Institute for Health Research (NIHR), Medical Research Council (MRC), Chief Scientist’s Office, Wellcome Trust (London, UK), Wellbeing of Women (London, UK) and Roche (Basel, Switzerland); grants and personal fees from Ferring Pharmaceuticals (Saint-Prex, Switzerland); and personal fees from Nordic Pharma (Reading, UK), Roche Diagnostics and AbbVie (North Chicago, IL, USA), outside the submitted work. Katy Vincent reports grants and personal fees from Bayer Healthcare (Leverkusen, Germany) and personal fees from Grünenthal (Aachen, Germany), Eli Lilly and Company (Indianapolis, IN, USA) and AbbVie, outside the submitted work. Jane P Daniels is a member of the NIHR Clinical Trials Unit Standing Advisory Committee (2017 to present).

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