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Daily consumption of two common probiotic strains did not reduce cumulative systemic antibiotic administration days for all-cause acute infections in care home residents.
1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
2 Centre for Trials Research, Cardiff University, Cardiff, UK
3 Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK
4 Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
5 Specialist Antimicrobial Chemotherapy Unit, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK
6 Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
* Corresponding author Email: Christopher.butler@phc.ox.ac.uk
Declared competing interests of authors: Christopher C Butler was a National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation board member from 2011 to 2016. Kerenza Hood is a member of the NIHR Health Technology Assessment (HTA) General Committee (2016 to present) and HTA Funding Committee Policy Group (2018 to present) and was a member of the Clinical Trials Unit Standing Advisory Committee until the end of 2018. David Gillespie is an associate member of the NIHR HTA General Committee (2019 to present). Nick A Francis is a member of the NIHR HTA General Committee (2019 to present). Philip C Calder reports personal fees and non-financial support from Chr. Hansen A/S (Hørsholm, Denmark) outside the submitted work. Paul Little was Programme Director of Programme Grants for Applied Research (PGfAR), Editor-in-Chief of the PGfAR journal and a member of NIHR Journals Library Board from 2012 to 2018.
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