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Daily consumption of two common probiotic strains did not reduce cumulative systemic antibiotic administration days for all-cause acute infections in care home residents.

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Christopher C Butler 1,*, Eleri Owen-Jones 2, Mandy Lau 2, David Gillespie 2, Mark Lown 3, Philip C Calder 4, Helen Stanton 2, Mandy Wootton 5, Vivian Castro Herrera 4, Antony Bayer 6, Jane Davies 2, Alison Edwards 2, Mina Davoudianfar 1, Heather Rutter 1, Kerenza Hood 2, Michael Moore 3, Paul Little 3, Victoria Shepherd 2, Rachel Lowe 2, Elizabeth A Miles 4, Julia Townson 2, FD Richard Hobbs 1, Nick A Francis 3

1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
2 Centre for Trials Research, Cardiff University, Cardiff, UK
3 Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK
4 Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
5 Specialist Antimicrobial Chemotherapy Unit, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK
6 Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK
* Corresponding author Email: Christopher.butler@phc.ox.ac.uk

Declared competing interests of authors: Christopher C Butler was a National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation board member from 2011 to 2016. Kerenza Hood is a member of the NIHR Health Technology Assessment (HTA) General Committee (2016 to present) and HTA Funding Committee Policy Group (2018 to present) and was a member of the Clinical Trials Unit Standing Advisory Committee until the end of 2018. David Gillespie is an associate member of the NIHR HTA General Committee (2019 to present). Nick A Francis is a member of the NIHR HTA General Committee (2019 to present). Philip C Calder reports personal fees and non-financial support from Chr. Hansen A/S (Hørsholm, Denmark) outside the submitted work. Paul Little was Programme Director of Programme Grants for Applied Research (PGfAR), Editor-in-Chief of the PGfAR journal and a member of NIHR Journals Library Board from 2012 to 2018.

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