Safety of reducing antibiotic prescribing in primary care: a mixed-methods study

Gulliford, Martin C; Charlton, Judith; Boiko, Olga; Winter, Joanne R; Rezel-Potts, Emma; Sun, Xiaohui; Burgess, Caroline; McDermott, Lisa; Bunce, Catey; Shearer, James; Curcin, Vasa; Fox, Robin; Hay, Alastair D; Little, Paul; Moore, Michael V; Ashworth, Mark

doi:10.3310/hsdr09090

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This study found that serious bacterial infections remain infrequent even without antibiotic treatment and identified risk strata in which antibiotic prescribing can be more safely reduced.

Martin C Gulliford , Judith Charlton , Olga Boiko , Joanne R Winter , Emma Rezel-Potts , Xiaohui Sun , Caroline Burgess , Lisa McDermott , Catey Bunce , James Shearer , Vasa Curcin , Robin Fox , Alastair D Hay , Paul Little , Michael V Moore & Mark Ashworth .

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Martin C Gulliford ^1,^2,^*, Judith Charlton ¹, Olga Boiko ¹, Joanne R Winter ^1,², Emma Rezel-Potts ^1,², Xiaohui Sun ¹, Caroline Burgess ¹, Lisa McDermott ¹, Catey Bunce ^1,², James Shearer ¹, Vasa Curcin ¹, Robin Fox ³, Alastair D Hay ⁴, Paul Little ⁵, Michael V Moore ⁵, Mark Ashworth ¹

¹ School of Population Health and Environmental Sciences, King’s College London, London, UK
² National Institute for Health Research Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
³ Bicester Health Centre, Bicester, UK
⁴ Centre for Academic Primary Care, Bristol Medical School, University of Bristol, Bristol, UK
⁵ Primary Care Research Group, University of Southampton, Southampton, UK
^* Corresponding author Email: martin.gulliford@kcl.ac.uk

Declared competing interests of authors: Michael V Moore reports grants from the National Institute for Health Research (NIHR) during the conduct of the study (awards 13/88/13 and 09/127/19). Paul Little was a board member for the NIHR School for Primary Care Research and was the programme director of the NIHR Programme Grants for Applied Research programme and a member of the NIHR Journals Library Editorial Group from September 2012 to September 2018.

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