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Nadeem Qureshi, Bethan Woods, Rita Neves de Faria, Pedro Saramago Goncalves, Edward Cox, Jo Leonardi-Bee, Laura Condon, Stephen Weng, Ralph K Akyea, Barbara Iyen, Paul Roderick, Steve E Humphries, William Rowlands, Melanie Watson, Kate Haralambos, Ryan Kenny, Dev Datta, Zosia Miedzybrodzka, Christopher Byrne & Joe Kai.

Nadeem Qureshi ^1,*, Bethan Woods ², Rita Neves de Faria ², Pedro Saramago Goncalves ², Edward Cox ², Jo Leonardi-Bee ¹, Laura Condon ¹, Stephen Weng ³, Ralph K Akyea ¹, Barbara Iyen ¹, Paul Roderick ⁴, Steve E Humphries ⁵, William Rowlands ⁶, Melanie Watson ⁷, Kate Haralambos ⁸, Ryan Kenny ⁹, Dev Datta ¹⁰, Zosia Miedzybrodzka ¹¹, Christopher Byrne ¹², Joe Kai ¹

¹ PRISM Research Group, Centre for Academic Primary Care, School of Medicine, University of Nottingham, Nottingham, UK
² Centre for Health Economics, University of York, York, UK
³ Cardiovascular and Metabolism, Janssen Research and Development, High Wycombe, UK
⁴ Primary Care, Population Sciences and Medical Education, University of Southampton, Southampton, UK
⁵ Centre for Cardiovascular Genetics, Institute for Cardiovascular Science, University College London, London, UK
⁶ Patient representative, ,
⁷ Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK
⁸ Familial Hypercholesterolaemia Service, University Hospital of Wales, Cardiff, UK
⁹ Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK
¹⁰ Lipid Unit, University Hospital Llandough, Penarth, UK
¹¹ Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
¹² Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
^* Corresponding author Email: nadeem.qureshi@nottingham.ac.uk

Disclosure of interests

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the tool kit on the NIHR journals Library report publication page at https://doi.org/10.3310/CTMD0148.

Primary conflicts of interest: Nadeem Qureshi has received grants from the National Institute for Health and Care Research (NIHR) School for Primary Care Research (SPCR) and the Medical Research Council (MRC) (Newton–Ungku Omar Fund), has received honoraria from Amgen Inc. (Thousand Oaks, CA, USA) for lectures on familial hypercholesterolaemia, is a member of the board for the NIHR SPCR (2021 to present) and is a member of the Medical, Scientific and Research Committee of HEART UK. Bethan Woods reports membership of the NIHR Health Technology Assessment Clinical Evaluation and Trials Funding Committee (2020–24). Jo Leonardi-Bee has received a grant from the MRC to conduct research in the field of familial hypercholesterolaemia. Stephen Weng was part of an institution that received grants from the NIHR SPCR for research related to familial hypercholesterolaemia, has received consulting fees from the Academic Advisory Committee for RoadtoHealth Ltd (Hailsham, UK), has received honoraria and travel fees from Amgen Inc. for lectures on familial hypercholesterolaemia, was previously a committee member for the Medicines and Healthcare products Regulatory Agency Clinical Practice Research Datalink Independent Scientific Advisory Committee and is currently employed by Janssen R&D, High Wycombe, UK. Steve E Humphries has received support from the British Heart Foundation (PG 008/08); is the director of the UK Familial Hypercholesterolaemia Paediatric Register, which has received support from a grant from the International Atherosclerosis Society (Pfizer number 24052829); and is a medical director and minor shareholder of the University College London Business Ltd spinout company StoreGene (London, UK), which offers deoxyribonucleic acid (DNA) testing for individuals with familial hypercholesterolaemia. Kate Haralambos has received payment for PASS (PASS Software, Rijswijk, the Netherlands) clinical data entry and for extracting and processing data. Dev Datta has received personal honoraria from Daiichi Sankyo Company, Ltd (Tokyo, Japan), Pfizer Inc. (New York City, NY, USA), Ionis Pharmaceuticals, Inc. (Carlsbad, CA, USA), Amgen Inc., Akcea Therapeutics, Inc. (Ionis Pharmaceuticals, Inc.), Novartis AG (Basel, Switzerland) and Amryt Pharma plc (Dublin, Ireland), which are all manufacturers in the field of lipidology. Zosia Miedzybrodzka has received payment for arranging data extraction and for presenting data in Scottish health data Safe Haven (Grampian Data Safe Haven, University of Aberdeen) and has received funding from Amgen Inc. and Akcea Therapeutics, Inc. Joe Kai is a member of the NIHR SPCR board (2015 to present).