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This trial and the subsequent review showed that performing endometrial scratch prior to the first cycle of IVF did not increase live birth rates compared with IVF without this procedure.

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Mostafa Metwally 1,*, Robin Chatters 2, Clare Pye 1, Munya Dimairo 2, David White 2, Stephen Walters 3, Judith Cohen 4, Tracey Young 5, Ying Cheong 6, Susan Laird 7, Lamiya Mohiyiddeen 8, Tim Chater 2, Kirsty Pemberton 2, Chris Turtle 2, Jamie Hall 2, Liz Taylor 1, Kate Brian 9, Anya Sizer 9, Helen Hunter 10

1 Assisted Conception Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
2 Sheffield Clinical Trials Research Unit (CTRU), School of Health and Related Research (ScHARR), The University of Sheffield, Sheffield, UK
3 Design, Trials and Statistics, School of Health and Related Research (ScHARR), Sheffield, UK
4 Hull Health Trials Unit, University of Hull, Hull, UK
5 Health Economic and Decision Science, School of Health and Related Research (ScHARR), Sheffield, UK
6 Faculty of Medicine, University of Southampton, Southampton, UK
7 Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, UK
8 Saint Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK
9 Fertility Network UK, Greenwich, UK
10 Department of Reproductive Medicine, Old St Mary’s Hospital, Manchester, UK
* Corresponding author Email: Mmetwally@sheffield.ac.uk

Declared competing interests of authors: Stephen Walters is a National Institute for Health Research (NIHR) Senior Investigator (2018 to present) and was a member of the following committees during the project: NIHR Health Technology Assessment (HTA) Clinical Trials and Evaluation Committee (2011–17), NIHR HTA Commissioning Strategy Group (2012–17), NIHR Programme Grants for Applied Research Committee (2020 to present) and the NIHR Pre-doctoral Fellowship Committee (2019 to present). He also reports book royalties from Wiley-Blackwell (Hoboken, NJ, USA), and fees from acting as an external examiner at various higher education institutes. Clare Pye reports grants from NIHR for studies NIHR128137 and NIHR128969. David White reports grants from NIHR for the following studies: HTA 15/35/03, HTA 16/81/01, Heath and Social Care Delivery Research 15/136/07, RP-PG-1016-20006, Horizon 2020 – 755094, NIHR128969 and NIHR128137.

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