Diagnostic accuracy and clinical impact of MRI-based technologies for patients with non-alcoholic fatty liver disease: systematic review and economic evaluation

Bresnahan, Rebecca; Duarte, Rui; Mahon, James; Beale, Sophie; Chaplin, Marty; Bhattacharyya, Devarshi; Houten, Rachel; Edwards, Katherine; Nevitt, Sarah; Maden, Michelle; Boland, Angela

doi:10.3310/KGJU3398

An error occurred retrieving publication content to display, please try again.

Page not found (404)

Sorry - the page you requested could not be found.

Please choose a page from the navigation or try a website search above to find the information you need.

Extended Research Article

Toolkit

View Award

Rebecca Bresnahan , Rui Duarte , James Mahon , Sophie Beale , Marty Chaplin , Devarshi Bhattacharyya , Rachel Houten , Katherine Edwards , Sarah Nevitt , Michelle Maden & Angela Boland .

Detailed Author information
Detailed Author information

Rebecca Bresnahan ^1,^*, Rui Duarte ¹, James Mahon ², Sophie Beale ³, Marty Chaplin ¹, Devarshi Bhattacharyya ¹, Rachel Houten ¹, Katherine Edwards ¹, Sarah Nevitt ¹, Michelle Maden ¹, Angela Boland ¹

¹ LRiG, Department of Health Data Science, University of Liverpool, Liverpool, UK
² Coldingham Analytical Services, Berwickshire, UK
³ Hare Research, North Yorkshire, UK
^* Corresponding author Email: rebecca.bresnahan@liverpool.ac.uk

Disclosure of interests of authors

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/KGJU3398.

Primary conflicts of interest: Rui Duarte is a member of the HTA Commissioning Committee (May 2021 to May 2025).

Funding: {{metadata.Funding}}

{{metadata.Journal}} Volume: {{metadata.Volume}}, Issue: {{metadata.Issue}}, Published in {{metadata.PublicationDate | date:'MMMM yyyy'}}

https://doi.org/{{metadata.DOI}}

Citation:{{author}}{{ (($index < metadata.AuthorsArray.length-1) && ($index <=6)) ? ', ' : '' }}{{(metadata.AuthorsArray.length <= 6) ? '.' : '' }} {{(metadata.AuthorsArray.length > 6) ? 'et al. ' : ''}}. {{metadata.JournalShortName}} {{metadata.PublicationDate | date:'yyyy'}};{{metadata.Volume}}({{metadata.Issue}})

Report Content

Full Report
Abstract
Plain English Summary
Plain Language Summary
Scientific Summary

The full text of this issue is available as a PDF document from the Toolkit section on this page.

Responses to this report

Response by Dr Angela Boland on 12 August 2024 at 3:30 PM
Authors response to comment
Based on the available evidence, the authors found that the benefits of the imaging technologies considered as part of the appraisal were limited. In some scenarios, use of these imaging technologies led to some patients being falsely identified as having no liver disease, which would have had negative consequences for these patients. In all scenarios considered by the authors, costs were higher if imagining was introduced before biopsy. Whilst biopsy is not without risks, the economic model attempts to balance these risks against the risks of falsely identifying patients as having no liver disease. The costs of biopsy in the study are based on NHS Reference Costs; these take into account the time and materials used in the procedure. The authors found it unlikely that the introduction of imaging prior to biopsy would be a cost effective use of NHS resources.

Response by Daniel on 20 October 2023 at 6:07 PM
The Future Of Health
This report appears to be recommending liver biopsy over non-invasive imaging. As a liver patient this is concerning to me and doesn’t seem to be safe or in patients’ best interest. Also I would be interested to see the cost analysis of the biopsy taking into count the hospital time involved.

If you would like to submit a response to this publication, please do so using the form below:

Comments submitted to the NIHR Journals Library are electronic letters to the editor. They enable our readers to debate issues raised in research reports published in the Journals Library. We aim to post within 14 working days all responses that contribute substantially to the topic investigated, as determined by the Editors. Non-relevant comments will be deleted.

Your name and affiliations will be published with your comment.

Once published, you will not have the right to remove or edit your response. The Editors may add, remove, or edit comments at their absolute discretion.

Enter response message*

Name (title, first name, last name)*

Occupation / Job title*

Affiliation / Employer*

Email*

Other authors
For example, if you are responding as a team or group. Please ensure you include full names and separate these using commas

Statement of competing interests
We believe that readers should be aware of any competing interests (conflicts of interest).
The International Committee of Medical Journal Editors (ICMJE) define competing interests as including: financial relationships with industry (for example through employment, consultancies, stock, ownership, honoraria, and expert testimony), either directly or through immediate family; personal relationships; academic competition; and intellectual passion.

If yes, please provide details below

Enter response title*

Enter CAPTCHA What is thirty divided by five?*

By submitting your response, you are stating that you agree to the terms & conditions

An error has occurred in processing the XML document