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Peter S Blair, Grace J Young, Clare Clement, Padraig Dixon, Penny Seume, Jenny Ingram, Jodi Taylor, Jeremy Horwood, Patricia J Lucas, Christie Cabral, Nick A Francis, Elizabeth Beech, Martin Gulliford, Sam Creavin, Janet A Lane, Scott Bevan & Alastair D Hay.

Peter S Blair ^1,*, Grace J Young ², Clare Clement ², Padraig Dixon ³, Penny Seume ⁴, Jenny Ingram ¹, Jodi Taylor ², Jeremy Horwood ⁴, Patricia J Lucas ⁵, Christie Cabral ⁴, Nick A Francis ⁶, Elizabeth Beech ⁷, Martin Gulliford ⁸, Sam Creavin ⁴, Janet A Lane ², Scott Bevan ², Alastair D Hay ⁴

¹ Centre for Academic Child Health, University of Bristol, Bristol Medical School, Bristol, UK
² Bristol Trials Centre (Bristol Randomised Trials Collaboration), Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK
³ Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Primary Care Building, Oxford, UK
⁴ Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, UK
⁵ School for Policy Studies, University of Bristol, Bristol, UK
⁶ Primary Care and Population Sciences, University of Southampton, Aldermoor Health Centre, Southampton, UK
⁷ NHS England and NHS Improvement, South West, UK
⁸ School of Population Health and Environmental Sciences, King’s College London, London, UK
^* Corresponding author Email: p.s.blair@bristol.ac.uk

Disclosure of interests

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/UCTH3411.

Primary conflicts of interest: Peter Blair, Padraig Dixon, Jenny Ingram, Jeremy Horwood, Patricia Lucas, Christie Cabral, Nick Francis, Elizabeth Beech, Martin Gulliford, Sam Creavin, Janet Lane and Alistair Hay were all co-investigators of the CHICO trial, so they were in receipt of NIHR funding. Alistair Hay is a member of the NIHR EME Committee and, at the time of funding, was a member of the NIHRHTA Committee. Jane Lane is a member of a clinical trials unit in receipt of NIHR support funding. Sam Creavin’s institution receives payments for the EMIS® development time, Wellcome trust doctoral fellowship and their NIHR ACL. Sam Creavin has a membership with HTA PCCPI Panel –May 2018, HTA Prioritisation Committee A (out of hospital) – May 2018–March 2022 and NICE diagnostic advisory committee – October 2022 to the present. Martin Gulliford was a member of the HSDR Funding Committee – May 2016–May 2019.

Trial registration: This trial is registered as ISRCTN11405239 (date assigned 20 April 2018) at www.controlled-trials.com (accessed 5 September 2022). Version 4.0 of the protocol is available at: https://www.journalslibrary.nihr.ac.uk/ (accessed 5 September 2022).

EudraCT number: Not required as non-CTIMP study.