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Peter J Hutchinson, Ellie Edlmann, John G Hanrahan, Diederik Bulters, Ardalan Zolnourian, Patrick Holton, Nigel Suttner, Kevin Agyemang, Simon Thomson, Ian A Anderson, Yahia Al-Tamimi, Duncan Henderson, Peter Whitfield, Monica Gherle, Paul M Brennan, Annabel Allison, Eric P Thelin, Silvia Tarantino, Beatrice Pantaleo, Karen Caldwell, Carol Davis-Wilkie, Harry Mee, Elizabeth A Warburton, Garry Barton, Aswin Chari, Hani J Marcus, Sarah Pyne, Andrew T King, Antonio Belli, Phyo K Myint, Ian Wilkinson, Thomas Santarius, Carole Turner, Simon Bond & Angelos G Kolias.

Peter J Hutchinson ^1,*, Ellie Edlmann ^1,2,3, John G Hanrahan ¹, Diederik Bulters ⁴, Ardalan Zolnourian ⁴, Patrick Holton ⁴, Nigel Suttner ⁵, Kevin Agyemang ⁵, Simon Thomson ⁶, Ian A Anderson ⁶, Yahia Al-Tamimi ⁷, Duncan Henderson ⁷, Peter Whitfield ³, Monica Gherle ³, Paul M Brennan ⁸, Annabel Allison ⁹, Eric P Thelin ^1,10, Silvia Tarantino ¹, Beatrice Pantaleo ⁹, Karen Caldwell ¹, Carol Davis-Wilkie ⁹, Harry Mee ¹, Elizabeth A Warburton ¹, Garry Barton ¹¹, Aswin Chari ¹², Hani J Marcus ¹³, Sarah Pyne ¹¹, Andrew T King ¹⁴, Antonio Belli ¹⁵, Phyo K Myint ¹⁶, Ian Wilkinson ^9,17, Thomas Santarius ¹, Carole Turner ¹, Simon Bond ⁹, Angelos G Kolias ¹

¹ Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke’s Hospital & University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK
² Faculty of Health, Medicine, Dentistry and Human Sciences, University of Plymouth, Plymouth, UK
³ South West Neurosurgical Centre, Derriford Hospital, Plymouth, UK
⁴ Wessex Neurological Unit, University Hospital Southampton, Southampton, UK
⁵ Department of Neurosurgery, Queen Elizabeth University Hospital, Glasgow, UK
⁶ Department of Neurosurgery, Leeds General Infirmary, Leeds, UK
⁷ Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, UK
⁸ Translational Neurosurgery, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
⁹ Cambridge Clinical Trials Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
¹⁰ Department of Neurology, Karolinska University Hospital, Stockholm, Sweden
¹¹ Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norfolk, UK
¹² Department of Neurosurgery, Great Ormond Street Hospital & Institute of Child Health, University College London, London, UK
¹³ National Hospital for Neurology and Neurosurgery, London, UK
¹⁴ Department of Neurosurgery, Manchester Centre for Clinical Neurosciences, Salford Royal Hospital, Manchester Academic Health Science Centre, Manchester, UK
¹⁵ NIHR Surgical Reconstruction and Microbiology Research Centre and Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK
¹⁶ Ageing Clinical & Experimental Research Group, Institute of Applied Health Science, University of Aberdeen, Aberdeen, UK
¹⁷ Division of Experimental Medicine and Immunotherapeutics, Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK
^* Corresponding author Email: pjah2@cam.ac.uk

^† Listed in Appendix 1

Disclosure of interests

Listed in Appendix 1

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/XWZN4832.

Primary conflicts of interest: Peter J Hutchinson was a member of the Health Technology Assessment (HTA) Programme Intellectual Property Panel (January 2016 to May 2018), and is currently a member of the HTA Prioritisation Committee B (in hospital). Antonio Belli reports being employed by and owning shares in Marker Diagnostics (Birmingham, UK). Elizabeth A Warburton is currently a member of the HTA Clinical Evaluation and Trials Committee (2019–present). Garry Barton was a member of the Norwich Clinical Trials Unit funded by the National Institute for Health and Care Research (NIHR) (until August 2021). Ian Wilkinson was a member of the Cambridge Clinical Trials Unit funded by NIHR (until August 2021). Simon Bond was a member of the Efficacy and Mechanism Evaluation Funding Committee (May 2015 to May 2019). Ellie Edlmann reports grants from Royal College of Surgeons and Rosetrees Trust Research Fellowship, during the conduct of the study. Carol Davis-Wilkie was funded as an employee of the Cambridge Clinical Trials Unit.