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Martha MC Elwenspoek, Howard Thom, Athena L Sheppard, Edna Keeney, Rachel O’Donnell, Joni Jackson, Cristina Roadevin, Sarah Dawson, Deborah Lane, Jo Stubbs, Hazel Everitt, Jessica C Watson, Alastair D Hay, Peter Gillett, Gerry Robins, Hayley E Jones, Sue Mallett & Penny F Whiting.

Martha MC Elwenspoek ^1,2,*, Howard Thom ², Athena L Sheppard ^1,2,3, Edna Keeney ², Rachel O’Donnell ^1,2, Joni Jackson ^1,2, Cristina Roadevin ², Sarah Dawson ², Deborah Lane ⁴, Jo Stubbs ⁴, Hazel Everitt ⁵, Jessica C Watson ², Alastair D Hay ², Peter Gillett ⁶, Gerry Robins ⁷, Hayley E Jones ², Sue Mallett ⁸, Penny F Whiting ²

¹ National Institute for Health and Care Research Applied Research Collaboration West, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
² Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
³ Department of Health Sciences, University of Leicester, Leicester, UK
⁴ Patient representative, , UK
⁵ Primary Care Research Centre, Population Sciences and Medical Education, University of Southampton, Southampton, UK
⁶ Paediatric Gastroenterology, Hepatology and Nutrition Department, Royal Hospital for Sick Children, Edinburgh, UK
⁷ Department of Gastroenterology, York Teaching Hospital NHS Foundation Trust, York, UK
⁸ Centre for Medical Imaging, University College London, London, UK
^* Corresponding author Email: Martha.Elwenspoek@bristol.ac.uk

Declared competing interests of authors: Howard Thom reports grants from the National Institute for Health and Care Research (NIHR) [Health Technology Assessment (HTA) 18/134 and NIHR Bristol Biomedical Research Centre], and the Medical Research Council (MRC) (MR/S036709/1); Howard Thom is also a part owner of Clifton Insight and has received consulting fees, paid to Clifton Insight, from Novartis International AG (Basel, Switzerland), F. Hoffmann-La Roche AG (Basel, Switzerland), Pfizer Inc. (New York, NY, USA), Bristol Myers Squibb™ (BMS) (New York, NY, USA), Eisai Co., Ltd (Tokyo, Japan), Argenx (Ghent, Belgium), H. Lundbeck A/S (Copenhagen, Denmark) and Janssen Pharmaceuticals (Beerse, Belgium). He has also received other fees from Clifton Insight. Athena L Sheppard reports grants from the NIHR HTA programme (18/134), payments made to their institution, an employment contract with F. Hoffmann-La Roche (2020), a training grant from the National Centre for Research Methods and a travel grant from the Royal Statistical Society. Edna Keeney reports personal fees from Novartis International AG, F. Hoffmann-La Roche, Pfizer Inc. and BMS. Alastair D Hay reports grants from NIHR (Senior Investigator Award NIHR200151), and membership of the Efficacy and Mechanism Evaluation (EME) Funding Committee (2019 to present) and the National Institute for Health and Care Excellence managing common infections committee (2019 to present). Gerry Robins reports membership of the Trustee Board for Coeliac UK (High Wycombe, UK). Hayley E Jones reports grants from MRC-NIHR (New Investigator Research Grant MR/T044594/1) and consulting fees from Aquarius Population Health (London, UK).