The clinical and cost effectiveness of testing for cytochrome P450 polymorphisms in patients treated with antipsychotics: a systematic review and economic evaluation

Fleeman, N; McLeod, C; Bagust, A; Beale, S; Boland, A; Dundar, Y; Jorgensen, A; Payne, K; Pirmohamed, M; Pushpakom, S; Walley, T; de Warren-Penny, P; Dickson, R

doi:10.3310/hta14030

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Review found that cytochrome P450 pharmacogenetic testing in adults entering antipsychotic treatment for schizophrenia may show promise in terms of predicting adverse drug reactions such as tardive dyskinesia but further evidence for clinical effectiveness and cost-effectiveness is required

N Fleeman, C McLeod, A Bagust, S Beale, A Boland, Y Dundar, A Jorgensen, K Payne, M Pirmohamed, S Pushpakom, T Walley, P de Warren-Penny & R Dickson.

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N Fleeman ¹, C McLeod ¹, A Bagust ¹, S Beale ², A Boland ¹, Y Dundar ^1,³, A Jorgensen ⁴, K Payne ⁵, M Pirmohamed ⁶, S Pushpakom ⁶, T Walley ¹, P de Warren-Penny ⁷, R Dickson ^1,^*

¹ Liverpool Reviews and Implementation Group (LRiG), University of Liverpool, , UK
² York Health Economics Consortium, University of York, , UK
³ Health Methodology Research Group, School of Community Based Medicine, University of Manchester, , UK
⁴ Medical Statistics, University of Liverpool, , UK
⁵ The Hesketh Centre, Merseyside NHS Trust, Southport, UK
⁶ Department of Pharmacology and Therapeutics, University of Liverpool, , UK
⁷ North Devon District Hospital, Barnstaple, UK
^* Corresponding author Email: Nigel.Fleeman@liverpool.ac.uk

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