The use of MElatonin in children with Neurodevelopmental Disorders and impaired Sleep: a randomised, double-blind, placebo-controlled, parallel study (MENDS)

Appleton, RE; Jones, AP; Gamble, C; Williamson, PR; Wiggs, L; Montgomery, P; Sutcliffe, A; Barker, C; Gringras, P

doi:10.3310/hta16400

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Study found that melatonin increases total sleep time in children with neurodevelopmental delay but that the increase is not clinically worthwhile and that melatonin is effective in reducing sleep-onset latency in children with neurodevelopmental delay and that the reduction is both clinically important and statistically significant.

RE Appleton, AP Jones, C Gamble, PR Williamson, L Wiggs, P Montgomery, A Sutcliffe, C Barker & P Gringras.

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RE Appleton ^1,^*, AP Jones ², C Gamble ², PR Williamson ², L Wiggs ³, P Montgomery ⁴, A Sutcliffe ⁵, C Barker ¹, P Gringras ⁶

¹ Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
² Medicines for Children Research Network Clinical Trials Unit, University of Liverpool, Liverpool, UK
³ Department of Psychology, Oxford Brookes University, Oxford, UK
⁴ Centre for Evidence Based Intervention, University of Oxford, Oxford, UK
⁵ University College London, London, UK
⁶ Guy’s and St Thomas’ NHS Foundation Trust, London, UK
^* Corresponding author Email: Richard.Appleton@alderhey.nhs.uk

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