The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients

Roberts, I; Shakur, H; Coats, T; Hunt, B; Balogun, E; Barnetson, L; Cook, L; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Cairns, J; Guerriero, C

doi:10.3310/hta17100

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Study found that early administration of tranexamic acid safely reduced the risk of death in bleeding trauma patients and is highly cost-effective.

I Roberts, H Shakur, T Coats, B Hunt, E Balogun, L Barnetson, L Cook, T Kawahara, P Perel, D Prieto-Merino, M Ramos, J Cairns & C Guerriero.

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I Roberts ^1,^*, H Shakur ¹, T Coats ², B Hunt ³, E Balogun ¹, L Barnetson ¹, L Cook ¹, T Kawahara ¹, P Perel ¹, D Prieto-Merino ¹, M Ramos ¹, J Cairns ⁴, C Guerriero ⁴

¹ Clinical Trials Unit, London School of Hygiene and Tropical Medicine, London, UK
² Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
³ Guy's and St Thomas' NHS Foundation Trust, King's College London, London, UK
⁴ Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
^* Corresponding author Email: ian.roberts@lshtm.ac.uk

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