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1 Clinical Trials Research Centre, University of Liverpool, Liverpool, UK
2 Ysbyty Gwynedd, Betsi Cadwalladr University Health Board, Bangor, UK
3 Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK
4 School of Medicine, Cardiff University, Cardiff, UK
5 Centre for Economics and Policy in Health, Bangor University, Bangor, UK
6 Department of Biostatistics, University of Liverpool, Liverpool, UK
7 Department of Health Sciences, University of York, York, UK
8 College of Medicine, Swansea University, Swansea, UK
9 North Wales Centre for Primary Care Research, Bangor University, Bangor, UK
10 Medical Biochemistry & Immunology, University Hospital of Wales, Cardiff, UK
11 School of Healthcare Sciences, Bangor University, Bangor, UK
12 Clinical Trials Unit, University College London, London, UK
13 Department of Psychological Medicine, University of Otago, Christchurch, New Zealand
14 North Wales Organisation for Randomised Trials in Health, Bangor University, Bangor, UK
* Corresponding author Email: i.t.russell@swansea.ac.uk
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