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1 Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
2 Health Economics Research Group, Brunel University, Uxbridge, UK
3 Faculty of Health Sciences, University of Southampton, Southampton, UK
4 University College London, London, UK
5 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
* Corresponding author Email: Mark.williams@ndorms.ox.ac.uk
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