Clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in critical care using multi-pathogen real-time polymerase chain reaction (RT-PCR) technology

Warhurst, Geoffrey; Dunn, Graham; Chadwick, Paul; Blackwood, Bronagh; McAuley, Daniel; Perkins, Gavin D; McMullan, Ronan; Gates, Simon; Bentley, Andrew; Young, Duncan; Carlson, Gordon L; Dark, Paul

doi:10.3310/hta19350

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Geoffrey Warhurst, Graham Dunn, Paul Chadwick, Bronagh Blackwood, Daniel McAuley, Gavin D Perkins, Ronan McMullan, Simon Gates, Andrew Bentley, Duncan Young, Gordon L Carlson & Paul Dark.

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Geoffrey Warhurst ^1,^2,^3,^*, Graham Dunn ⁴, Paul Chadwick ⁵, Bronagh Blackwood ⁶, Daniel McAuley ⁶, Gavin D Perkins ⁷, Ronan McMullan ⁸, Simon Gates ⁷, Andrew Bentley ^3,⁹, Duncan Young ¹⁰, Gordon L Carlson ^1,³, Paul Dark ^1,^3,¹¹

¹ Infection, Injury and Inflammation Research Group, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Salford, UK
² Faculty of Environment and Life Sciences, University of Salford, Manchester Academic Health Sciences Centre (MAHSC), Salford, UK
³ Institute of Inflammation and Repair, Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Salford, UK
⁴ Centre for Biostatistics, Institute of Population Health, Faculty of Medical and Human Sciences, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Salford, UK
⁵ Microbiology Department, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Salford, UK
⁶ Centre for Infection and Immunity, Queen’s University Belfast, Belfast, UK
⁷ Clinical Trials Unit, Medical School, Warwick University, Coventry, UK
⁸ Medical Microbiology, Royal Victoria Hospital, Belfast, UK
⁹ Intensive Care Unit, University Hospital of South Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), Manchester, UK
¹⁰ Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK
¹¹ Intensive Care Unit, Salford Royal NHS Foundation Trust, Manchester Academic Health Sciences Centre (MAHSC), University of Manchester, Salford, UK
^* Corresponding author Email: Geoffrey.warhurst@manchester.ac.uk

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