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1 Centre for Biostatistics, Institute of Population Health, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK
2 Medical Research Council North West Hub for Trials Methodology Research, , UK
3 Department of Biostatistics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
4 Institute of Brain, Behaviour and Mental Health, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK
5 Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge, UK
* Corresponding author Email: Graham.Dunn@manchester.ac.uk
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