Prehospital randomised assessment of a mechanical compression device in out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised trial and economic evaluation

Gates, Simon; Lall, Ranjit; Quinn, Tom; Deakin, Charles D; Cooke, Matthew W; Horton, Jessica; Lamb, Sarah E; Slowther, Anne-Marie; Woollard, Malcolm; Carson, Andy; Smyth, Mike; Wilson, Kate; Parcell, Garry; Rosser, Andrew; Whitfield, Richard; Williams, Amanda; Jones, Rebecca; Pocock, Helen; Brock, Nicola; Black, John JM; Wright, John; Han, Kyee; Shaw, Gary; Blair, Laura; Marti, Joachim; Hulme, Claire; McCabe, Christopher; Nikolova, Silviya; Ferreira, Zenia; Perkins, Gavin D

doi:10.3310/hta21110

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For people with out-of-hospital cardiac arrest, LUCAS-2 mechanical compression was more expensive than usual care and led to no improvement in 30-day survival.

Simon Gates, Ranjit Lall, Tom Quinn, Charles D Deakin, Matthew W Cooke, Jessica Horton, Sarah E Lamb, Anne-Marie Slowther, Malcolm Woollard, Andy Carson, Mike Smyth, Kate Wilson, Garry Parcell, Andrew Rosser, Richard Whitfield, Amanda Williams, Rebecca Jones, Helen Pocock, Nicola Brock, John JM Black, John Wright, Kyee Han, Gary Shaw, Laura Blair, Joachim Marti, Claire Hulme, Christopher McCabe, Silviya Nikolova, Zenia Ferreira & Gavin D Perkins.

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Simon Gates ^1,^*, Ranjit Lall ¹, Tom Quinn ², Charles D Deakin ³, Matthew W Cooke ^1,⁴, Jessica Horton ¹, Sarah E Lamb ^1,⁵, Anne-Marie Slowther ¹, Malcolm Woollard ², Andy Carson ⁶, Mike Smyth ^1,⁶, Kate Wilson ⁶, Garry Parcell ⁶, Andrew Rosser ⁶, Richard Whitfield ⁷, Amanda Williams ⁷, Rebecca Jones ⁷, Helen Pocock ³, Nicola Brock ³, John JM Black ³, John Wright ^8,⁹, Kyee Han ⁸, Gary Shaw ⁸, Laura Blair ⁸, Joachim Marti ¹⁰, Claire Hulme ¹⁰, Christopher McCabe ¹¹, Silviya Nikolova ¹⁰, Zenia Ferreira ¹⁰, Gavin D Perkins ^1,⁴

¹ Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
² Surrey Peri-operative Anaesthesia Critical Care Collaborative Research Group, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK (current address: Faculty of Health, Social Care and Education, Kingston University London and St George’s, University of London, London, UK
³ South Central Ambulance Service NHS Foundation Trust, Otterbourne, UK
⁴ Heart of England NHS Foundation Trust, Birmingham, UK
⁵ Oxford Clinical Trials Research Unit, University of Oxford, Oxford, UK
⁶ West Midlands Ambulance Service NHS Foundation Trust, Brierley Hill, UK
⁷ Welsh Ambulance Services NHS Trust, St Asaph, UK
⁸ North East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK
⁹ Royal Victoria Infirmary, Newcastle upon Tyne, UK
¹⁰ Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds, Leeds, UK
¹¹ Department of Emergency Medicine Research, University of Alberta, Edmonton, AB, Canada
^* Corresponding author Email: s.gates@warwick.ac.uk

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