Amisulpride augmentation in clozapine-unresponsive schizophrenia (AMICUS): a double-blind, placebo-controlled, randomised trial of clinical effectiveness and cost-effectiveness

Barnes, Thomas RE; Leeson, Verity C; Paton, Carol; Marston, Louise; Davies, Linda; Whittaker, William; Osborn, David; Kumar, Raj; Keown, Patrick; Zafar, Rameez; Iqbal, Khalid; Singh, Vineet; Fridrich, Pavel; Fitzgerald, Zachary; Bagalkote, Hemant; Haddad, Peter M; Husni, Mariwan; Amos, Tim

doi:10.3310/hta21490

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This trial of adding amisulpride in clozapine-unresponsive schizophrenia under-recruited and did not show any statistically significant response at 12 weeks.

Thomas RE Barnes, Verity C Leeson, Carol Paton, Louise Marston, Linda Davies, William Whittaker, David Osborn, Raj Kumar, Patrick Keown, Rameez Zafar, Khalid Iqbal, Vineet Singh, Pavel Fridrich, Zachary Fitzgerald, Hemant Bagalkote, Peter M Haddad, Mariwan Husni & Tim Amos.

Detailed Author information
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Thomas RE Barnes ^1,^2,^*, Verity C Leeson ¹, Carol Paton ^1,³, Louise Marston ^4,⁵, Linda Davies ⁶, William Whittaker ⁶, David Osborn ^7,⁸, Raj Kumar ⁹, Patrick Keown ^10,¹¹, Rameez Zafar ¹², Khalid Iqbal ¹³, Vineet Singh ¹⁴, Pavel Fridrich ¹⁵, Zachary Fitzgerald ¹⁶, Hemant Bagalkote ¹⁷, Peter M Haddad ^18,¹⁹, Mariwan Husni ^20,²¹, Tim Amos ^22,²³

¹ Centre for Mental Health, Imperial College London, London, UK
² West London Mental Health NHS Trust, London, UK
³ Oxleas NHS Foundation Trust, London, UK
⁴ Department of Primary Care and Population Health, University College London, London, UK
⁵ PRIMENT Clinical Trials Unit, University College London, London, UK
⁶ Centre for Health Economics, Institute of Population Health, University of Manchester, Manchester, UK
⁷ Division of Psychiatry, University College London, London, UK
⁸ Camden and Islington NHS Foundation Trust, London, UK
⁹ Tees, Esk and Wear Valley NHS Foundation Trust, Billingham, UK
¹⁰ Northumberland Tyne and Wear NHS Foundation Trust, Newcastle upon Tyne, UK
¹¹ Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK
¹² Lincolnshire Partnership NHS Foundation Trust, Lincoln, UK
¹³ Bradford District Care Trust, Bradford, UK
¹⁴ Derbyshire Healthcare NHS Foundation Trust, Derby, UK
¹⁵ North Essex Partnership University NHS Foundation Trust, Chelmsford, UK
¹⁶ Manchester Mental Health and Social Care NHS Trust, Manchester, UK
¹⁷ Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK
¹⁸ Greater Manchester West Mental Health NHS Foundation Trust, Manchester, UK
¹⁹ Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
²⁰ Central and North West London NHS Foundation Trust, London, UK
²¹ Northern Ontario School of Medicine, Sudbury, ON, Canada
²² Avon and Wiltshire Mental Health Partnership NHS Trust, Bristol, UK
²³ School of Social and Community Medicine, University of Bristol, Bristol, UK
^* Corresponding author Email: t.r.barnes@imperial.ac.uk

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