Amaze: a double-blind, multicentre randomised controlled trial to investigate the clinical effectiveness and cost-effectiveness of adding an ablation device-based maze procedure as an adjunct to routine cardiac surgery for patients with pre-existing atrial fibrillation

Sharples, Linda; Everett, Colin; Singh, Jeshika; Mills, Christine; Spyt, Tom; Abu-Omar, Yasir; Fynn, Simon; Thorpe, Benjamin; Stoneman, Victoria; Goddard, Hester; Fox-Rushby, Julia; Nashef, Samer

doi:10.3310/hta22190

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Adjunct atrial fibrillation surgery increased sinus rhythm restoration, cost about £3000 more, but did not improve quality-adjusted survival at 2 years.

Linda Sharples , Colin Everett , Jeshika Singh , Christine Mills , Tom Spyt , Yasir Abu-Omar , Simon Fynn , Benjamin Thorpe , Victoria Stoneman , Hester Goddard , Julia Fox-Rushby & Samer Nashef .

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Linda Sharples ^1,^*, Colin Everett ², Jeshika Singh ³, Christine Mills ⁴, Tom Spyt ⁵, Yasir Abu-Omar ⁶, Simon Fynn ⁶, Benjamin Thorpe ², Victoria Stoneman ⁴, Hester Goddard ⁴, Julia Fox-Rushby ⁷, Samer Nashef ⁶

¹ Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK
² Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK
³ Health Economics Research Group (HERG), Brunel University London, London, UK
⁴ Papworth Trials Unit Collaboration, Papworth Hospital, Cambridge, UK
⁵ Department of Cardiac Surgery, Glenfield Hospital, Leicester, UK
⁶ Department of Cardiology and Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, UK
⁷ Department of Population Science, King’s College London, London, UK
^* Corresponding author Email: Linda.Sharples@lshtm.ac.uk

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