AVURT: aspirin versus placebo for the treatment of venous leg ulcers   a Phase II pilot randomised controlled trial

Tilbrook, Helen; Clark, Laura; Cook, Liz; Bland, Martin; Buckley, Hannah; Chetter, Ian; Dumville, Jo; Fenner, Chris; Forsythe, Rachael; Gabe, Rhian; Harding, Keith; Layton, Alison; Lindsay, Ellie; McDaid, Catriona; Moffatt, Christine; Rolfe, Debbie; Sbizzera, Illary; Stansby, Gerard; Torgerson, David; Vowden, Peter; Williams, Laurie; Hinchliffe, Robert

doi:10.3310/hta22550

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This trial only recruited 27 of the target 100 participants with leg ulcers, due to many patients not meeting the eligibility criteria, and found no evidence that aspirin speeded up healing.

Helen Tilbrook , Laura Clark , Liz Cook , Martin Bland , Hannah Buckley , Ian Chetter , Jo Dumville , Chris Fenner , Rachael Forsythe , Rhian Gabe , Keith Harding , Alison Layton , Ellie Lindsay , Catriona McDaid , Christine Moffatt , Debbie Rolfe , Illary Sbizzera , Gerard Stansby , David Torgerson , Peter Vowden , Laurie Williams & Robert Hinchliffe .

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Helen Tilbrook ¹, Laura Clark ¹, Liz Cook ¹, Martin Bland ², Hannah Buckley ³, Ian Chetter ⁴, Jo Dumville ⁵, Chris Fenner ⁶, Rachael Forsythe ⁷, Rhian Gabe ⁸, Keith Harding ⁹, Alison Layton ¹⁰, Ellie Lindsay ¹¹, Catriona McDaid ¹, Christine Moffatt ¹², Debbie Rolfe ¹³, Illary Sbizzera ¹, Gerard Stansby ¹⁴, David Torgerson ¹, Peter Vowden ¹⁵, Laurie Williams ¹⁶, Robert Hinchliffe ^17,^*

¹ York Trials Unit, Department of Health Sciences, University of York, York, UK
² Department of Health Sciences, University of York, York, UK
³ Cancer Division, Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK
⁴ Academic Vascular Surgical Unit, Hull Royal Infirmary, Hull, UK
⁵ Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
⁶ Orthopaedic Department, West Middlesex Hospital, Isleworth, UK
⁷ Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
⁸ Hull York Medical School and York Trials Unit, Department of Health Sciences, University of York, York, UK
⁹ Wound Healing, School of Medicine, Cardiff University, Cardiff, UK
¹⁰ Harrogate and District NHS Foundation Trust, Harrogate, UK
¹¹ The Lindsay Leg Club Foundation, Ipswich, UK
¹² School of Health Sciences, University of Nottingham, Royal Derby Hospital, Derby, UK
¹³ Joint Research and Enterprise Office, St George’s University of London, London, UK
¹⁴ Freeman Hospital, Newcastle upon Tyne, UK
¹⁵ Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford, UK
¹⁶ Lay representative, ,
¹⁷ Bristol Centre for Surgical Research, National Institute for Health Research (NIHR) Biomedical Research Centre, University of Bristol, Bristol, UK
^* Corresponding author Email: robert.hinchliffe@bristol.ac.uk

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