Gentamicin as an alternative to ceftriaxone in the treatment of gonorrhoea: the G-TOG non-inferiority RCT

Ross, Jonathan D C; Harding, Jan; Duley, Lelia; Montgomery, Alan A; Hepburn, Trish; Tan, Wei; Brittain, Clare; Meakin, Garry; Sprange, Kirsty; Thandi, Sukhwinder; Jackson, Louise; Roberts, Tracy; Wilson, Janet; White, John; Dewsnap, Claire; Cole, Michelle; Lawrence, Tessa

doi:10.3310/hta23200

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This trial was unable to demonstrate the non-inferiority of gentamicin compared with ceftriaxone in the clearance of gonorrhoea at all infected sites.

Jonathan D C Ross , Jan Harding , Lelia Duley , Alan A Montgomery , Trish Hepburn , Wei Tan , Clare Brittain , Garry Meakin , Kirsty Sprange , Sukhwinder Thandi , Louise Jackson , Tracy Roberts , Janet Wilson , John White , Claire Dewsnap , Michelle Cole & Tessa Lawrence .

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Jonathan D C Ross ^1,^*, Jan Harding ¹, Lelia Duley ², Alan A Montgomery ², Trish Hepburn ², Wei Tan ², Clare Brittain ², Garry Meakin ², Kirsty Sprange ², Sukhwinder Thandi ², Louise Jackson ³, Tracy Roberts ³, Janet Wilson ⁴, John White ⁵, Claire Dewsnap ⁶, Michelle Cole ⁷, Tessa Lawrence ¹

¹ Whittall Street Clinic, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
² Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
³ Health Economics Unit, University of Birmingham, Birmingham, UK
⁴ Leeds Centre for Sexual Health, Leeds, UK
⁵ Burrell Street Clinic, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
⁶ Sheffield Royal Hallamshire Hospital, Sheffield, UK
⁷ Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI), National Infection Service, Public Health England, London, UK
^* Corresponding author Email: jonathan.ross@uhb.nhs.uk

^† See Acknowledgements for details

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