Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation

Takwoingi, Yemisi; Whitworth, Hilary; Rees-Roberts, Melanie; Badhan, Amarjit; Partlett, Christopher; Green, Nathan; Boakye, Aime; Lambie, Heather; Marongiu, Luigi; Jit, Mark; White, Peter; Deeks, Jonathan J; Kon, Onn Min; Lalvani, Ajit

doi:10.3310/hta23230

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Of two interferon-gamma release assays, T-SPOT.TB was more sensitive than QFT-GIT in diagnosing active TB, but both were insufficiently sensitive for ruling out active TB in routine UK clinical practice.

Yemisi Takwoingi, Hilary Whitworth, Melanie Rees-Roberts, Amarjit Badhan, Christopher Partlett, Nathan Green, Aime Boakye, Heather Lambie, Luigi Marongiu, Mark Jit, Peter White, Jonathan J Deeks, Onn Min Kon & Ajit Lalvani.

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Yemisi Takwoingi ¹, Hilary Whitworth ^2,³, Melanie Rees-Roberts ^2,⁴, Amarjit Badhan ^2,⁴, Christopher Partlett ¹, Nathan Green ^5,^6,^7,⁸, Aime Boakye ^2,⁴, Heather Lambie ², Luigi Marongiu ², Mark Jit ^8,⁹, Peter White ^5,^6,^7,⁸, Jonathan J Deeks ¹, Onn Min Kon ^2,^4,¹⁰, Ajit Lalvani ^2,^4,^*

¹ Institute of Applied Health Research, University of Birmingham, Birmingham, UK
² Tuberculosis Research Centre, National Heart and Lung Institute, Imperial College London, London, UK
³ Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK
⁴ National Institute for Health Research (NIHR) Health Protection Research Unit in Respiratory Infections, Imperial College London, London, UK
⁵ NIHR Health Protection Research Unit in Modelling Methodology, Imperial College London, London, UK
⁶ Medical Research Council (MRC) Centre for Outbreak Analysis and Modelling, Imperial College London, London, UK
⁷ Department of Infectious Disease Epidemiology, Imperial College London, London, UK
⁸ Modelling and Economics Unit, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK
⁹ Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
¹⁰ St Mary’s Hospital, Imperial College Healthcare Trust, London, UK
^* Corresponding author Email: a.lalvani@imperial.ac.uk

^† For a full list of IDEA study collaborators, please see Acknowledgements

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