Sixteen-week versus standard eight-week prednisolone therapy for childhood nephrotic syndrome: the PREDNOS RCT

Webb, Nicholas JA; Woolley, Rebecca L; Lambe, Tosin; Frew, Emma; Brettell, Elizabeth A; Barsoum, Emma N; Trompeter, Richard S; Cummins, Carole; Wheatley, Keith; Ives, Natalie J

doi:10.3310/hta23260

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There was no clinical benefit for extended course prednisolone therapy for children with nephrotic syndrome.

Nicholas JA Webb , Rebecca L Woolley , Tosin Lambe , Emma Frew , Elizabeth A Brettell , Emma N Barsoum , Richard S Trompeter , Carole Cummins , Keith Wheatley & Natalie J Ives .

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Nicholas JA Webb ^1,^*, Rebecca L Woolley ², Tosin Lambe ³, Emma Frew ³, Elizabeth A Brettell ², Emma N Barsoum ², Richard S Trompeter ⁴, Carole Cummins ⁵, Keith Wheatley ⁶, Natalie J Ives ²

¹ Department of Paediatric Nephrology, University of Manchester, Manchester Academic Health Science Centre, Royal Manchester Children’s Hospital, Manchester, UK
² Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK
³ Health Economics Unit, University of Birmingham, Birmingham, UK
⁴ Centre for Nephrology, University College London, , UK
⁵ Institute of Applied Health Research, University of Birmingham, Birmingham, UK
⁶ Cancer Research UK Clinical Trials Unit, University of Birmingham, Birmingham, UK
^* Corresponding author Email: nicholas.webb@novartis.com

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