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Nikola Sprigg, Katie Flaherty, Jason P Appleton, Rustam Al-Shahi Salman, Daniel Bereczki, Maia Beridze, Alfonso Ciccone, Ronan Collins, Robert A Dineen, Lelia Duley, Juan José Egea-Guerrero, Timothy J England, Michal Karlinski, Kailash Krishnan, Ann Charlotte Laska, Zhe Kang Law, Christian Ovesen, Serefnur Ozturk, Stuart J Pocock, Ian Roberts, Thompson G Robinson, Christine Roffe, Nils Peters, Polly Scutt, Jegan Thanabalan, David Werring, David Whynes, Lisa Woodhouse, Philip M Bath & for the TICH-2 Investigators.

Nikola Sprigg ^1,2,*, Katie Flaherty ¹, Jason P Appleton ¹, Rustam Al-Shahi Salman ³, Daniel Bereczki ⁴, Maia Beridze ⁵, Alfonso Ciccone ⁶, Ronan Collins ⁷, Robert A Dineen ^8,9, Lelia Duley ¹⁰, Juan José Egea-Guerrero ¹¹, Timothy J England ¹², Michal Karlinski ¹³, Kailash Krishnan ^1,2, Ann Charlotte Laska ¹⁴, Zhe Kang Law ^1,2,15, Christian Ovesen ¹⁶, Serefnur Ozturk ¹⁷, Stuart J Pocock ¹⁸, Ian Roberts ¹⁹, Thompson G Robinson ²⁰, Christine Roffe ²¹, Nils Peters ²², Polly Scutt ¹, Jegan Thanabalan ²³, David Werring ^24,25, David Whynes ²⁶, Lisa Woodhouse ¹, Philip M Bath ^1,2,

¹ Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
² Stroke, Nottingham University Hospitals NHS Trust, Nottingham, UK
³ Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
⁴ Department of Neurology, Semmelweis University, Budapest, Hungary
⁵ The First University Clinic of Tbilisi State Medical University, Tbilisi, Georgia
⁶ Neurology Unit, Azienda Socio Sanitaria Territoriale di Mantova, Mantua, Italy
⁷ Stroke Service, Adelaide and Meath Hospital, Tallaght, Ireland
⁸ Radiological Sciences, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK
⁹ NIHR Nottingham Biomedical Research Centre, Nottingham, UK
¹⁰ Nottingham Clinical Trials Unit, University of Nottingham, Nottingham, UK
¹¹ UGC de Medicina Intensiva, Hospital Universitario Virgen del Rocío, IBiS/CSIC/Universidad de Sevilla, Seville, Spain
¹² Vascular Medicine, Division of Medical Sciences & GEM, University of Nottingham, Derby, UK
¹³ Second Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland
¹⁴ Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
¹⁵ Department of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia
¹⁶ Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Department of Neurology, Copenhagen, Denmark
¹⁷ Department of Neurology, Selcuk University Medical Faculty, Konya, Turkey
¹⁸ Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK
¹⁹ Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
²⁰ Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK
²¹ Stroke Research, Faculty of Medicine and Health Sciences, Keele University, Keele, UK
²² Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland
²³ Division of Neurosurgery, Department of Surgery, National University of Malaysia, Kuala Lumpur, Malaysia
²⁴ Stroke Research Centre, University College London Queen Square Institute of Neurology, Faculty of Brain Sciences of University College London, University College London, London, UK
²⁵ National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
²⁶ School of Economics, University of Nottingham, Nottingham, UK
^* Corresponding author Email: Nikola.sprigg@nottingham.ac.uk