Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care: the Breathe RCT

Perkins, Gavin D; Mistry, Dipesh; Lall, Ranjit; Gao-Smith, Fang; Snelson, Catherine; Hart, Nicholas; Camporota, Luigi; Varley, James; Carle, Coralie; Paramasivam, Elankumaran; Hoddell, Beverly; de Paeztron, Adam; Dosanjh, Sukhdeep; Sampson, Julia; Blair, Laura; Couper, Keith; McAuley, Daniel; Young, J Duncan; Walsh, Tim; Blackwood, Bronagh; Rose, Louise; Lamb, Sarah E; Dritsaki, Melina; Maredza, Mandy; Khan, Iftekhar; Petrou, Stavros; Gates, Simon

doi:10.3310/hta23480

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A protocolised non-invasive weaning strategy did not reduce time to liberation from ventilation, although there were other possible advantages for patients.

Gavin D Perkins , Dipesh Mistry , Ranjit Lall , Fang Gao-Smith , Catherine Snelson , Nicholas Hart , Luigi Camporota , James Varley , Coralie Carle , Elankumaran Paramasivam , Beverly Hoddell , Adam de Paeztron , Sukhdeep Dosanjh , Julia Sampson , Laura Blair , Keith Couper , Daniel McAuley , J Duncan Young , Tim Walsh , Bronagh Blackwood , Louise Rose , Sarah E Lamb , Melina Dritsaki , Mandy Maredza , Iftekhar Khan , Stavros Petrou & Simon Gates .

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Gavin D Perkins ^1,^2,^*, Dipesh Mistry ¹, Ranjit Lall ¹, Fang Gao-Smith ², Catherine Snelson ³, Nicholas Hart ^4,⁵, Luigi Camporota ⁵, James Varley ⁶, Coralie Carle ⁷, Elankumaran Paramasivam ⁸, Beverly Hoddell ¹, Adam de Paeztron ¹, Sukhdeep Dosanjh ¹, Julia Sampson ^1,², Laura Blair ¹, Keith Couper ^1,², Daniel McAuley ⁹, J Duncan Young ¹⁰, Tim Walsh ¹¹, Bronagh Blackwood ⁹, Louise Rose ¹², Sarah E Lamb ¹, Melina Dritsaki ¹, Mandy Maredza ¹, Iftekhar Khan ^1,¹³, Stavros Petrou ¹, Simon Gates ¹

¹ Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
² Critical Care Unit, Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
³ Department of Critical Care, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
⁴ Division of Asthma, Allergy and Lung Biology, King’s College London, London, UK
⁵ Guy’s and St Thomas’ Foundation Trust, King’s College London, London, UK
⁶ Department of Critical Care, Addenbrooke’s Hospital, Cambridge University Hospitals, Cambridge, UK
⁷ Department of Critical Care, Peterborough City Hospital, Peterborough, UK
⁸ Department of Critical Care, Leeds Teaching Hospitals, Leeds, UK
⁹ School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine Institute for Health Sciences, Queen’s University Belfast, Belfast, UK
¹⁰ Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK
¹¹ Anaesthesia, Critical Care and Pain Medicine, Division of Health Sciences, The University of Edinburgh, Edinburgh, UK
¹² Faculty of Nursing, University of Toronto, Toronto, ON, Canada
¹³ Population and Patient Health, King’s College London, London, UK
^* Corresponding author Email: G.D.Perkins@warwick.ac.uk

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