Intravenous co-amoxiclav to prevent infection after operative vaginal delivery: the ANODE RCT

Knight, Marian; Chiocchia, Virginia; Partlett, Christopher; Rivero-Arias, Oliver; Hua, Xinyang; Bowler, Ursula; Gray, James; Gray, Shan; Hinshaw, Kim; Khunda, Aethele; Moore, Philip; Mottram, Linda; Owino, Nelly; Pasupathy, Dharmintra; Sanders, Julia; Sultan, Abdul H; Thakar, Ranee; Tuffnell, Derek; Linsell, Louise; Juszczak, Edmund

doi:10.3310/hta23540

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Women randomised to a single dose of co-amoxiclav were less likely to have confirmed or suspected infection within 6 weeks of giving birth.

Marian Knight , Virginia Chiocchia , Christopher Partlett , Oliver Rivero-Arias , Xinyang Hua , Ursula Bowler , James Gray , Shan Gray , Kim Hinshaw , Aethele Khunda , Philip Moore , Linda Mottram , Nelly Owino , Dharmintra Pasupathy , Julia Sanders , Abdul H Sultan , Ranee Thakar , Derek Tuffnell , Louise Linsell & Edmund Juszczak .

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Marian Knight ^1,^*, Virginia Chiocchia ¹, Christopher Partlett ¹, Oliver Rivero-Arias ¹, Xinyang Hua ¹, Ursula Bowler ¹, James Gray ², Shan Gray ¹, Kim Hinshaw ^3,⁴, Aethele Khunda ⁵, Philip Moore ², Linda Mottram ¹, Nelly Owino ¹, Dharmintra Pasupathy ⁶, Julia Sanders ^7,⁸, Abdul H Sultan ⁹, Ranee Thakar ⁹, Derek Tuffnell ¹⁰, Louise Linsell ¹, Edmund Juszczak ¹

¹ National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
² Department of Microbiology, Birmingham Women’s & Children’s NHS Foundation Trust, Birmingham, UK
³ Department of Obstetrics and Gynaecology, City Hospitals Sunderland NHS Foundation Trust, Sunderland, UK
⁴ Faculty of Health Sciences, University of Sunderland, Sunderland, UK
⁵ Department of Women’s Health, James Cook University Hospital, Middlesbrough, UK
⁶ Department of Women and Children’s Health, School of Life Course Sciences, King’s College London, King’s Health Partners, London, UK
⁷ School of Healthcare Sciences, Cardiff University, Cardiff, UK
⁸ Department of Women’s Health, Cardiff and Vale University Health Board, Cardiff, UK
⁹ Department of Obstetrics and Gynaecology, Croydon University Hospital, Croydon, UK
¹⁰ Department of Women’s Health, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
^* Corresponding author Email: marian.knight@npeu.ox.ac.uk

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