Prophylactic levofloxacin to prevent infections in newly diagnosed symptomatic myeloma: the TEAMM RCT

Drayson, Mark T; Bowcock, Stella; Planche, Tim; Iqbal, Gulnaz; Pratt, Guy; Yong, Kwee; Wood, Jill; Raynes, Kerry; Higgins, Helen; Dawkins, Bryony; Meads, David; Hulme, Claire T; Whittaker, Anna C; Hawkey, Peter; Low, Eric; Dunn, Janet A

doi:10.3310/hta23620

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During the 12 weeks from new diagnosis, the addition of prophylactic levofloxacin to active myeloma treatment significantly reduced febrile episodes and deaths without increasing healthcare associated infections or carriage.

Mark T Drayson , Stella Bowcock , Tim Planche , Gulnaz Iqbal , Guy Pratt , Kwee Yong, Jill Wood , Kerry Raynes , Helen Higgins , Bryony Dawkins , David Meads , Claire T Hulme , Anna C Whittaker , Peter Hawkey, Eric Low & Janet A Dunn .

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Mark T Drayson ^1,^*, Stella Bowcock ², Tim Planche ³, Gulnaz Iqbal ⁴, Guy Pratt ⁵, Kwee Yong ⁶, Jill Wood ⁴, Kerry Raynes ⁴, Helen Higgins ⁴, Bryony Dawkins ⁷, David Meads ⁷, Claire T Hulme ⁷, Anna C Whittaker ⁸, Peter Hawkey ⁹, Eric Low ¹⁰, Janet A Dunn ⁴

¹ Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
² King’s College Hospital NHS Foundation Trust, London, UK
³ Institute of Infection and Immunity, St George’s Hospital, University of London, London, UK
⁴ Warwick Clinical Trials Unit, University of Warwick, Coventry, UK
⁵ University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
⁶ Department of Haematology, University College London Cancer Institute, London, UK
⁷ Academic Unit of Health Economics, University of Leeds, Leeds, UK
⁸ School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK
⁹ Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK
¹⁰ Patient Advocacy, Myeloma UK, Edinburgh, UK
^* Corresponding author Email: M.T.Drayson@bham.ac.uk

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