High-dose oral vitamin D supplementation and mortality in people aged 65 84 years: the VIDAL cluster feasibility RCT of open versus double-blind individual randomisation

Rake, Christine; Gilham, Clare; Bukasa, Laurette; Ostler, Richard; Newton, Michelle; Peto Wild, James; Aigret, Benoit; Hill, Michael; Gillie, Oliver; Nazareth, Irwin; Sasieni, Peter; Martineau, Adrian; Peto, Julian

doi:10.3310/hta24100

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This study found that a full trial of vitamin D was feasible with either open or double blind randomisation.

Christine Rake, Clare Gilham, Laurette Bukasa, Richard Ostler, Michelle Newton, James Peto Wild, Benoit Aigret, Michael Hill, Oliver Gillie, Irwin Nazareth, Peter Sasieni, Adrian Martineau & Julian Peto.

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Christine Rake ¹, Clare Gilham ¹, Laurette Bukasa ¹, Richard Ostler ², Michelle Newton ³, James Peto Wild ¹, Benoit Aigret ⁴, Michael Hill ⁵, Oliver Gillie ⁶, Irwin Nazareth ⁷, Peter Sasieni ^4,⁸, Adrian Martineau ⁹, Julian Peto ^1,^*

¹ Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK
² Computational and Analytical Sciences, Rothamsted Research, Harpenden, UK
³ Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
⁴ Barts Clinical Trials Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
⁵ Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK
⁶ Health Research Forum, London, UK
⁷ Department of Primary Care and Population Health, University College London, London, UK
⁸ King’s Clinical Trials Unit, King’s College London, London, UK
⁹ Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
^* Corresponding author Email: julian.peto@lshtm.ac.uk

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