Vaccine effectiveness of live attenuated and trivalent inactivated influenza vaccination in 2010/11 to 2015/16:  the SIVE II record linkage study

Simpson, Colin R; Lone, Nazir I; Kavanagh, Kim; Englishby, Tanya; Robertson, Chris; McMenamin, Jim; Wissman, Beatrix von; Vasileiou, Eleftheria; Butler, Christopher C; Ritchie, Lewis D; Gunson, Rory; Schwarze, Jürgen; Sheikh, Aziz

doi:10.3310/hta24670

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Live attenuated influenza vaccine was safe and decreased confirmed influenza in children, whereas this effect was smaller and less certain with the trivalent vaccine, particularly in over 65s.

Colin R Simpson , Nazir I Lone , Kim Kavanagh , Tanya Englishby, Chris Robertson , Jim McMenamin, Beatrix von Wissman, Eleftheria Vasileiou, Christopher C Butler , Lewis D Ritchie, Rory Gunson , Jürgen Schwarze & Aziz Sheikh .

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Colin R Simpson ^1,^2,^*, Nazir I Lone ², Kim Kavanagh ³, Tanya Englishby ³, Chris Robertson ^3,⁴, Jim McMenamin ⁴, Beatrix von Wissman ⁴, Eleftheria Vasileiou ², Christopher C Butler ^5,⁶, Lewis D Ritchie ⁷, Rory Gunson ⁸, Jürgen Schwarze ⁹, Aziz Sheikh ²

¹ School of Health, Faculty of Health, Victoria University of Wellington, Wellington, New Zealand
² Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK
³ Department of Mathematics and Statistics, University of Strathclyde, Glasgow, UK
⁴ Health Protection Scotland, Glasgow, UK
⁵ Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK
⁶ Institute of Primary Care and Public Health, Cardiff University, Cardiff, UK
⁷ Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK
⁸ West of Scotland Specialist Virology Centre, Glasgow Royal Infirmary, Glasgow, UK
⁹ Child Life and Health, Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
^* Corresponding author Email: colin.simpson@vuw.ac.nz

Declared competing interests of authors: Christopher C Butler was a member of the Efficacy and Mechanism Evaluation Board. Jürgen Schwarze reports personal fees from the Medical Research Council Infection and Immunity Board. Aziz Sheikh and Chris Robertson report grants from the National Institute for Health Research during the conduct of this study.

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