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This study found a trial comparing psychological interventions with antipsychotic medication and a combination treatment in young people with psychosis is feasible with some adaptations to the design.

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Anthony P Morrison 1,2,*, Melissa Pyle 1,2, Rory Byrne 1,2, Matthew Broome 3,4,5,6, Daniel Freeman 4,6, Louise Johns 4,6, Anthony James 4,6, Nusrat Husain 2,7, Richard Whale 8, Graeme MacLennan 9, John Norrie 10, Jemma Hudson 9, Sarah Peters 2, Linda Davies 2, Samantha Bowe 1, Jo Smith 11, David Shiers 1,2, Emmeline Joyce 1, Wendy Jones 1,2, Chris Hollis 12, Daniel Maughan 6

1 Psychosis Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK
2 Division of Psychology and Mental Health, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
3 Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK
4 Department of Psychiatry, Medical Sciences Division, University of Oxford, Oxford, UK
5 Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham, UK
6 Warneford Hospital, Oxford Health NHS Foundation Trust, Oxford, UK
7 Early Intervention in Psychosis Service, Lancashire and South Cumbria NHS Foundation Trust, Chorley, UK
8 Brighton and Sussex Medical School, University of Sussex, Brighton, UK
9 Health Services Research Unit, University of Aberdeen, Aberdeen, UK
10 Clinical Trials Unit, University of Edinburgh, Edinburgh, UK
11 School of Allied Health and Community, University of Worcester, Worcester, UK
12 National Institute for Health Research MindTech MedTech Co-operative, Division of Psychiatry and Applied Psychology, Institute of Mental Health, University of Nottingham, Nottingham, UK
* Corresponding author Email: anthony.p.morrison@manchester.ac.uk

Declared competing interests of authors: Anthony P Morrison reports personal fees from the provision of training workshops in cognitive–behavioural therapy for psychosis and royalties from books on the topic outside the submitted work. Melissa Pyle reports fees paid to the Psychosis Research Unit from cognitive–behavioural therapy training at Greater Manchester Mental Health NHS Foundation Trust (Manchester, UK). Rory Byrne reports personal fees from Oxford Cognitive Therapy Centre (Oxford, UK) outside the submitted work. Matthew Broom reports royalties from Oxford University Press (Oxford, UK) and personal fees from Medical Defence Union (London, UK) outside the submitted work. Daniel Freeman reports grants from the National Institute for Health Research (NIHR) and the Medical Research Council during the conduct of the study outside the submitted work. Louise Johns reports personal fees from New Harbinger Publications (Oakland, CA, USA) outside the submitted work. Nusrat Husain reports that he is the chairperson of the board of trustees of the Manchester Global Foundation (Manchester, UK), a charitable incorporated organisation registered in England and Wales; he is a past trustee of Lancashire Mind (Chorley, UK), Abaseen Foundation (Lancaster, UK) and the Pakistan Institute of Living and Learning (Karachi, Pakistan). Nusrat Husain reports that he established an independent general hospital (Remedial Centre) in Karachi, Pakistan; this is now owned and operated by his sibling, and the hospital is also attached to a pharmacy. Nusrat Husain reports that he has received an honorarium and travel grants from various pharmaceutical industries. Richard Whale reports conference attendance support from Sunovion Pharmaceuticals Inc. (Marlborough, MA, USA) and personal fees from Janssen: Pharmaceutical Companies of Johnson & Johnson (Beerse, Belgium) and from H. Lundbeck A/S (Copenhagen, Denmark) outside the submitted work. John Norrie reports membership of the following NIHR boards: cardiopulmonary resuscitation decision-making committee, Health Technology Assessment (HTA) programme Commissioning Board, HTA Commissioning Sub-board (expression of interest), HTA Funding Boards Policy Group, HTA General Board, HTA Post-Board funding teleconference, NIHR Clinical Trials Unit Standing Advisory Committee, NIHR HTA and Efficacy and Mechanism Evaluation Editorial Boards; and the Pre-exposure Prophylaxis Impact Review Panel. John Norrie also declares grants from the University of Aberdeen and the University of Edinburgh. Linda Davies reports grants from the University of Manchester during the conduct of the study. Samantha Bowe reports personal fees from private therapy practice, and personal fees from a cognitive–behavioural therapy training post at Greater Manchester Mental Health NHS Foundation Trust outside the submitted work. David Shiers reports personal fees from the National Clinical Audit of Psychosis, royalties from John Wiley & Sons, Inc. (Hoboken, NJ, USA) publication for ‘Promoting Recovery in Early Psychosis’ 2010 (ISBN 978-1-4051-4894-8) and reports membership of the current National Institute for Health and Care Excellence (NICE) guideline development group for rehabilitation in adults with complex psychosis and related severe mental health conditions. David Shiers is also a board member of the National Collaborating Centre for Mental Health (2013–present), expert adviser to the NICE centre for guidelines and clinical adviser to the National Clinical Audit of Psychosis outside the submitted work. Chris Hollis reports that he was chairperson of the NICE Guideline Development Group for Schizophrenia in Children & Young People (2011–13) and was chairperson of the NICE Psychosis and Schizophrenia in Children Evidence Update (2014–15) outside the submitted work.

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