Enzyme-linked immunosorbent assays for monitoring TNF-alpha inhibitors and antibody levels in people with rheumatoid arthritis: a systematic review and economic evaluation

Tikhonova, Irina A; Yang, Huiqin; Bello, Segun; Salmon, Andrew; Robinson, Sophie; Hemami, Mohsen Rezaei; Dodman, Sophie; Kharechko, Andriy; Haigh, Richard C; Jani, Meghna; McDonald, Timothy J; Hoyle, Martin

doi:10.3310/hta25080

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There is limited evidence and much uncertainty in relation to the clinical and cost-effectiveness of enzyme-linked immunosorbent assay-based therapeutic drug monitoring in rheumatoid arthritis.

Irina A Tikhonova , Huiqin Yang , Segun Bello , Andrew Salmon , Sophie Robinson , Mohsen Rezaei Hemami , Sophie Dodman , Andriy Kharechko , Richard C Haigh , Meghna Jani , Timothy J McDonald & Martin Hoyle .

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Irina A Tikhonova ^1,^2,^*, Huiqin Yang ¹, Segun Bello ¹, Andrew Salmon ³, Sophie Robinson ¹, Mohsen Rezaei Hemami ¹, Sophie Dodman ¹, Andriy Kharechko ¹, Richard C Haigh ⁴, Meghna Jani ⁵, Timothy J McDonald ^4,⁶, Martin Hoyle ¹

¹ Peninsula Technology Assessment Group (PenTAG), University of Exeter Medical School, Exeter, UK
² Southampton Health Technology Assessments Centre, University of Southampton, Southampton, UK
³ Peninsula Collaboration for Health Operational Research and Development, University of Exeter Medical School, Exeter, UK
⁴ Royal Devon & Exeter NHS Foundation Trust, Exeter, UK
⁵ Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Manchester, UK
⁶ University of Exeter Medical School, Exeter, UK
^* Corresponding author Email: I.Tikhonova@soton.ac.uk

Declared competing interests of authors: Meghna Jani declares receipt of speaker fees from Grifols–Progenika (Barcelona, Spain). Richard C Haigh reports grants from Pfizer (Sandwich, UK) and personal fees from Pfizer outside the submitted work.

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