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Preoperative intravenous iron was not superior to placebo in reducing mortality or need for blood transfusion when administered to patients with anaemia 10 42 days before elective major abdominal surgery.

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Toby Richards 1,2,3,*, Ravishankar Rao Baikady 4, Ben Clevenger 3,11, Anna Butcher 3, Sandy Abeysiri 2,3, Marisa Chau 2,3, Rebecca Swinson 5, Tim Collier 5, Matthew Dodd 5, Laura Van Dyck 5, Iain Macdougall 6, Gavin Murphy 7, John Browne 8, Andrew Bradbury 9, Andrew Klein 10

1 Division of Surgery, University of Western Australia, Perth, WA, Australia
2 Institute of Clinical Trial and Methodology, University College London, London, UK
3 Division of Surgery, University College London, London, UK
4 The Royal Marsden NHS Foundation Trust, London, UK
5 Clinical Trials Unit, London School of Hygiene & Tropical Medicine, London, UK
6 Department of Renal Medicine, King’s College Hospital, London, UK
7 NIHR Leicester Biomedical Research Centre, Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
8 School of Public Health, University College Cork, Cork, Ireland
9 University Department of Vascular Surgery (University of Birmingham), Solihull Hospital, Solihull, UK
10 Department of Anaesthesia and Intensive Care, Royal Papworth Hospital, Cambridge, UK
11 Department of Anaesthesia, Royal National Orthopaedic Hospital, Stanmore, UK
* Corresponding author Email: toby.richards@uwa.edu.au

Declared competing interests of authors: Andrew Klein reports grants and personal fees from Pharmacosmos A/S (Holbaek, Denmark) and Fisher and Paykel (Auckland, New Zealand), personal fees from Vifor Pharma (Glattbrugg, Switzerland) and Masimo (Irvine, CA, USA), and grants from Haemonetics® (Braintree, MA, USA) and HemoSonics (Charlottesville, VA, USA) outside the submitted work. Iain Macdougall reports grants and personal fees from Vifor Pharma outside the submitted work. Ravishankar Rao Baikady reports grants and other support from Pharmacosmos UK (Reading, UK), Vifor Pharma, Novo Nordisk A/S (Bagsværd, Denmark) and Fresenius Kabi (Bad Homburg, Germany) outside the submitted work. Gavin Murphy reports grants from Zimmer Biomet (Warsaw, IN, USA) and other from Terumo Corporation (Tokyo, Japan) outside the submitted work, and is part of Clinical Trials Units (CTUs) funded by the National Institute for Health Research (NIHR) CTU Standing Advisory Committee. Toby Richards reports grants from NIHR Health Technology Assessment (HTA) during the conduct of the study, grants, personal fees and non-financial support from Pharmocosmos and Vifor Pharma, and personal fees from Tiash Ltd (Republic of Singapore) outside the submitted work. Sandy Abeysiri reports grants from NIHR HTA during the conduct of the study and has been working on PREVENTT as part of her PhD at University College London. She has also worked at The Iron Clinic (London, UK), which provides intravenous iron therapy. Andrew Bradbury reports membership of the NIHR HTA Interventional Procedures Panel, NIHR HTA Prioritisation Group, NIHR HTA Remit and Competitiveness Committee and NIHR HTA Hospital Based Care Methods Group (2014–2020).

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