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This trial found that 3.2% of people treated with adrenaline following out-of-hospital cardiac arrest survived to 30 days, compared with 2.4% of people receiving placebo.

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Gavin D Perkins 1,2,*, Chen Ji 1, Felix Achana 1, John JM Black 3, Karl Charlton 4, James Crawford 1, Adam de Paeztron 1, Charles Deakin 5, Mark Docherty 6, Judith Finn 7, Rachael T Fothergill 8, Simon Gates 9, Imogen Gunson 6, Kyee Han 4, Susie Hennings 1, Jessica Horton 1, Kamran Khan 1, Sarah Lamb 1, John Long 10, Joshua Miller 6, Fionna Moore 11, Jerry Nolan 1,12, Lyndsey O’Shea 13, Stavros Petrou 1, Helen Pocock 3, Tom Quinn 14, Nigel Rees 13, Scott Regan 1, Andy Rosser 6, Charlotte Scomparin 1, Anne Slowther 1, Ranjit Lall 1

1 Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK
2 Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
3 South Central Ambulance Service NHS Foundation Trust, Bicester, UK
4 North East Ambulance Service NHS Foundation Trust, Newcastle upon Tyne, UK
5 Southampton University Hospital, Southampton, UK
6 West Midlands Ambulance Service University NHS Foundation Trust, Brierley Hill, UK
7 Prehospital, Resuscitation and Emergency Care Research Unit (PRECRU), Curtin University, Perth, WA, Australia
8 London Ambulance Service NHS Trust, London, UK
9 Cancer Research Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, UK
10 Patient and Public Involvement Representative, Warwick, UK
11 South East Coast Ambulance Service NHS Foundation Trust, Crawley, UK
12 Royal United Hospitals Bath NHS Foundation Trust, Bath, UK
13 Welsh Ambulance Service NHS Trust, St Asaph, UK
14 Emergency, Cardiovascular and Critical Care Research Group, Faculty of Health, Social Care and Education, Kingston University London and St George’s, University of London, London, UK
* Corresponding author Email: G.D.Perkins@warwick.ac.uk

Declared competing interests of authors: Gavin D Perkins is a board member of the Resuscitation Council (UK) (2010–present), the European Resuscitation Council (2016–present) and the International Liaison Committee on Resuscitation (co-chairperson; 2016–present), and is an editor for the scientific journal Resuscitation (2010–present). He was also a member of the National Institute for Health Research (NIHR) Programme Grants for Applied Research board (2016–20) and is a member of the NIHR Health Technology Assessment (HTA) board (2020–present). Charles Deakin is a member of the Advanced Life Support Working Group of the International Liaison Committee on Resuscitation (January 2002–present). Simon Gates is a member of the HTA General Committee (2018–present). Sarah Lamb was a member of the following boards: HTA Additional Capacity Funding Board (2012–15), HTA Clinical Trials Board (2010–15), HTA End of Life Care and Add on Studies (2015–15), HTA Funding Boards Policy Group (2010–15), HTA Maternal, Neonatal and Child Health Methods Group (2013–15), HTA Post-board Funding Teleconference (2010–15), HTA Primary Care Themed Call board (2013–14), HTA Prioritisation Group (2012–15) and the NIHR Clinical Trials Unit Standing Advisory Committee (2012–16). Tom Quinn reports grants from NIHR [Health Services and Delivery Research (HSDR) 11/2004/30 and HSDR 13/10/40)] and from the British Heart Foundation [Use and impact of the pre-hospital 12-lead electrocardiogram in the primary PCI era. Mixed method study (PHECG-2)], outside the submitted work. Anne Slowther reports grants from NIHR outside the submitted work (for HSDR 13/10/14 and HSDR 15/15/09) and that she is a member of the Board of Trustees of the UK Clinical Ethics Network (2013–present) and the Board of Trustees of the Institute of Medical Ethics (2005–present).

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